1 to 10 of 19 literature results

• In vivo colocalization of antigen and CpG [corrected] within dendritic cells is associated with the efficacy of cancer immunotherapy.

  Immunostimulatory cytidyl guanosyl (CpG) motifs are of great interest as cancer vaccine adjuvants. They act as potent inducers of Th1 responses, inclu…

  Authors: Stefan Nierkens, Martijn H den Brok, Roger P M Sutmuller, Oliver M Grauer, Erik Bennink, Mary E Morgan, Carl G Figdor, Theo J M Ruers, Gosse J Adema

  Source: Cancer research. 2008 Jul 1

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• Synergy between in situ cryoablation and TLR9 stimulation results in a highly effective in vivo dendritic cell vaccine.

  Dendritic cells (DC) are professional antigen-presenting cells that play a pivotal role in the induction of immunity. Ex vivo-generated, tumor antigen…

  Authors: Martijn H M G M den Brok, Roger P M Sutmuller, Stefan Nierkens, Erik J Bennink, Liza W J Toonen, Carl G Figdor, Theo J M Ruers, Gosse J Adema

  Source: Cancer research. 2006 Jul 15

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• Generation of antibody responses to pneumococcal capsular polysaccharides is independent of CD1 expression in mice.

  Streptococcus pneumoniae is a bacterial microorganism that frequently causes serious infection, particularly in children and the elderly. Protection a…

  Authors: Leen Moens, Axel Jeurissen, Stefan Nierkens, Louis Boon, Luc Van Kaer, Ahmad Kasran, Greet Wuyts, Jan L Ceuppens, Xavier Bossuyt

  Source: Infection and immunity. 2009 May

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• Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors.

  The brain is a specialized immune site representing a unique tumor microenvironment. The availability of fresh brain tumor material for ex vivo analys…

  Authors: Joannes F M Jacobs, Albert J Idema, Kalijn F Bol, Stefan Nierkens, Oliver M Grauer, Pieter Wesseling, J André Grotenhuis, Peter M Hoogerbrugge, I Jolanda M de Vries, Gosse J Adema

  Source: Neuro-oncology. 2009 Aug

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• Toll-like receptor signalling on Tregs: to suppress or not to suppress?

  To balance self-tolerance and immunity against pathogens or tumours, the immune system depends on both activation mechanisms and down-regulatory mecha…

  Authors: Wendy W C van Maren, Joannes F M Jacobs, I Jolanda M de Vries, Stefan Nierkens, Gosse J Adema

  Source: Immunology. 2008 Aug

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• The reactive D-glucopyranose moiety of streptozotocin is responsible for activation of macrophages and subsequent stimulation of CD8+ T cells.

  The antitumor drug streptozotocin (STZ) is commonly used as a diabetogenic compound in animal models. At relatively low doses, STZ-induced beta cell d…

  Authors: Stefan Nierkens, Rob Bleumink, Marianne Bol, Ine Hassing, Nico van Rooijen, Raymond Pieters

  Source: Chemical research in toxicology. 2005 May

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• Murine models of drug hypersensitivity.

  PURPOSE OF REVIEW: Drug hypersensitivity reactions are relatively rare but may result in severe morbidity and fatalities. Due to the idiosyncratic nat…

  Authors: Stefan Nierkens, Raymond Pieters

  Source: Current opinion in allergy and clinical immunology. 2005 Aug

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• Route of administration of the TLR9 agonist CpG critically determines the efficacy of cancer immunotherapy in mice.

  BACKGROUND: The TLR9 agonist CpG is increasingly applied in preclinical and clinical studies as a therapeutic modality to enhance tumor immunity. The …

  Authors: Stefan Nierkens, Martijn H den Brok, Thijs Roelofsen, Jori A L Wagenaars, Carl G Figdor, Theo J Ruers, Gosse J Adema

  Source: PloS one. 2009

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• TLR ligands in the local treatment of established intracerebral murine gliomas.

  Local TLR stimulation is an attractive approach to induce antitumor immunity. In this study, we compared various TLR ligands for their ability to affe…

  Authors: Oliver M Grauer, Johan W Molling, Erik Bennink, Liza W J Toonen, Roger P M Sutmuller, Stefan Nierkens, Gosse J Adema

  Source: Journal of immunology (Baltimore, Md. : 1950). 2008 Nov 15

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• Elimination of regulatory T cells is essential for an effective vaccination with tumor lysate-pulsed dendritic cells in a murine glioma model.

  Both melanoma and glioma cells are of neuroectodermal origin and share common tumor associated antigens. In this article, we report that the melanocyt…

  Authors: Oliver M Grauer, Roger P M Sutmuller, Wendy van Maren, Joannes F M Jacobs, Erik Bennink, Liza W J Toonen, Stefan Nierkens, Gosse J Adema

  Source: International journal of cancer. Journal international du cancer. 2008 Apr 15

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