1 to 7 of 7 literature results

• Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.

  Imatinib mesylate (Gleevec) is a small-molecule inhibitor of the fusion protein Bcr-Abl, the causal agent in chronic myelogenous leukemia. Here we rep…

  Authors: Risto Kerkelä, Luanda Grazette, Rinat Yacobi, Cezar Iliescu, Richard Patten, Cara Beahm, Brian Walters, Sergei Shevtsov, Stéphanie Pesant, Fred J Clubb,…

  Source: Nature medicine. 2006 Aug

  View Full Text

• Inhibition of angiotensin II Gq signaling augments beta-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure.

  Chronic ventricular pressure overload states, such as hypertension, and elevated levels of neurohormones (norepinephrine, angiotensin II, endothelin-1…

  Authors: David M Harris, Xiongwen Chen, Stéphanie Pesant, Heather I Cohn, Scott M MacDonnell, Matthieu Boucher, Leif E Vinge, Philip Raake, Susan R Moraca, Dongjun Li,…

  Source: Journal of molecular and cellular cardiology. 2009 Jan

  View Full Text

• Fibroblast apoptosis precedes cardiomyocyte mass reduction during left ventricular remodeling in hypertensive rats treated with amlodipine.

  BACKGROUND: A transient induction of apoptosis accompanies the normalization of left ventricular mass index in spontaneously hypertensive rats (SHR) t…

  Authors: David Duguay, Stéphanie Pesant, Christian F Deschepper, Denis deBlois

  Source: Journal of hypertension. 2007 Jun

  View Full Text

• Enhanced sterol response element-binding protein in postintervention restenotic blood vessels plays an important role in vascular smooth muscle proliferation.

  Postintervention restenosis (PIRS) after balloon angioplasty or stent implantation is a limitation for these interventional procedures even with the a…

  Authors: Rui-Hai Zhou, Stéphanie Pesant, Heather I Cohn, Andrea D Eckhart

  Source: Life sciences. 2008 Jan 16

  View Full Text

• Post-ischemic cardioprotection by A2A adenosine receptors: dependent of phosphatidylinositol 3-kinase pathway.

  Activation of myocardial A2A adenosine receptors during reperfusion has been shown to be cardioprotective. The intracellular mechanisms underlying thi…

  Authors: Matthieu Boucher, Stéphanie Pesant, Stéphanie Falcao, Chantal de Montigny, Erick Schampaert, René Cardinal, Guy Rousseau

  Source: Journal of cardiovascular pharmacology. 2004 Mar

  View Full Text

• GPCR signalling in hypertension: role of GRKs.

  Hypertension is a prevalent condition in the developed world and disease severity is directly correlated with additional cardiovascular complications.…

  Authors: David M Harris, Heather I Cohn, Stéphanie Pesant, Andrea D Eckhart

  Source: Clinical science (London, England : 1979). 2008 Aug

  View Full Text

• Vascular smooth muscle G(q) signaling is involved in high blood pressure in both induced renal and genetic vascular smooth muscle-derived models of hypertension.

  More than 30% of the US population has high blood pressure (BP), and less than a third of people treated for hypertension have it controlled. In addit…

  Authors: David M Harris, Heather I Cohn, Stéphanie Pesant, Rui-Hai Zhou, Andrea D Eckhart

  Source: American journal of physiology. Heart and circulatory physiology. 2007 Nov

  View Full Text