1 to 10 of 45 literature results

• The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways.

  The clonal expansion of chronic lymphocytic leukemia (CLL) cells requires the interaction with the microenvironment and is under the control of severa…

  Authors: Daniela de Totero, Raffaella Meazza, Matteo Capaia, Marina Fabbi, Bruno Azzarone, Enrico Balleari, Marco Gobbi, Giovanna Cutrona, Manlio Ferrarini, Silvano Ferrini

  Source: Blood. 2008 Jan 15

  View Full Text

• Human renal cancer cells express a novel membrane-bound interleukin-15 that induces, in response to the soluble interleukin-15 receptor alpha chain, epithelial-to-mesenchymal transition.

  Although interleukin-15 (IL-15) is a powerful immunomodulatory factor that has been proposed for cancer immunotherapy, its intratumoral expression may…

  Authors: Krystel Khawam, Julien Giron-Michel, Yanhong Gu, Aurélie Perier, Massimo Giuliani, Anne Caignard, Aurore Devocelle, Silvano Ferrini, Marina Fabbi, Bernard Charpentier,…

  Source: Cancer research. 2009 Feb 15

  View Full Text

• Cancer stem cells: a new paradigm for understanding tumor growth and progression and drug resistance.

  Normal somatic stem cells (SC) are naturally resistant to chemotherapeutic agents due to their expression of various membrane transporter molecules (s…

  Authors: Rosaria Gangemi, Laura Paleari, Anna Maria Orengo, Alfredo Cesario, Leonardo Chessa, Silvano Ferrini, Patrizia Russo

  Source: Current medicinal chemistry. 2009

  View Full Text

• Antimetastatic activity of a preventive cancer vaccine.

  The development of prophylactic cancer vaccines that protect healthy hosts from tumor development leaves open the question whether such vaccines are a…

  Authors: Patrizia Nanni, Giordano Nicoletti, Arianna Palladini, Stefania Croci, Annalisa Murgo, Agnese Antognoli, Lorena Landuzzi, Marina Fabbi, Silvano Ferrini, Piero Musiani,…

  Source: Cancer research. 2007 Nov 15

  View Full Text

• Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells.

  Interleukin-21 (IL-21) is a member of the IL-2 cytokine family, which mediates proliferation or growth arrest and apoptosis of normal B cells, dependi…

  Authors: Daniela de Totero, Raffaella Meazza, Simona Zupo, Giovanna Cutrona, Serena Matis, Monica Colombo, Enrico Balleari, Ivana Pierri, Marina Fabbi, Matteo Capaia,…

  Source: Blood. 2006 May 1

  View Full Text

• NK cells provide helper signal for CD8+ T cells by inducing the expression of membrane-bound IL-15 on DCs.

  NK cell recognition of cells that do not express or express low amounts of MHC class I molecules results not only in direct killing of target cells bu…

  Authors: Barbara Morandi, Lorenzo Mortara, Paolo Carrega, Claudia Cantoni, Gregorio Costa, Roberto S Accolla, Maria Cristina Mingari, Silvano Ferrini, Lorenzo Moretta, Guido Ferlazzo

  Source: International immunology. 2009 May

  View Full Text

• Inhibition of mammary carcinoma development in HER-2/neu transgenic mice through induction of autoimmunity by xenogeneic DNA vaccination.

  Plasmid DNA vectors encoding the full-length (VR1012/HER-2-FL) or only the extracellular and transmembrane domains (VR1012/HER-2-ECD-TM) of human (h) …

  Authors: Serenella M Pupa, Manuela Iezzi, Emma Di Carlo, AnnaMaria Invernizzi, Federica Cavallo, Raffaella Meazza, Alberto Comes, Silvano Ferrini, Piero Musiani, Sylvie Ménard

  Source: Cancer research. 2005 Feb 1

  View Full Text

• Membrane-bound and soluble IL-15/IL-15Ralpha complexes display differential signaling and functions on human hematopoietic progenitors.

  Membrane-bound and soluble interleukin-15 (IL-15)/IL-15 receptor alpha (Ralpha) complexes trigger differential transcription factor activation and fun…

  Authors: Julien Giron-Michel, Massimo Giuliani, Manuela Fogli, Danièle Brouty-Boyé, Silvano Ferrini, Florence Baychelier, Pierre Eid, Caroline Lebousse-Kerdilès, Deniz Durali, Roberto Biassoni,…

  Source: Blood. 2005 Oct 1

  View Full Text

• Internalization and recycling of ALCAM/CD166 detected by a fully human single-chain recombinant antibody.

  Activated leukocyte cell adhesion molecule (ALCAM/CD166), a member of the immunoglobulin superfamily with five extracellular immunoglobulin-like domai…

  Authors: Tiziana Piazza, Emanuela Cha, Italia Bongarzone, Silvana Canevari, Andrea Bolognesi, Letizia Polito, Antonio Bargellesi, Francesca Sassi, Silvano Ferrini, Marina Fabbi

  Source: Journal of cell science. 2005 Apr 1

  View Full Text

• Methylation of CIITA promoter IV causes loss of HLA-II inducibility by IFN-gamma in promyelocytic cells.

  The human promyelocytic cell line THP-1 expresses high level of HLA class II (HLA-II) molecules after IFN-gamma treatment. Here, we report a variant o…

  Authors: Andrea De Lerma Barbaro, Alessandro De Ambrosis, Barbara Banelli, Giuseppina Li Pira, Ottavia Aresu, Massimo Romani, Silvano Ferrini, Roberto S Accolla

  Source: International immunology. 2008 Nov

  View Free Full Text