1 to 10 of 147 literature results

• Alternative activation of macrophages: an immunologic functional perspective.

  Macrophages are innate immune cells with well-established roles in the primary response to pathogens, but also in tissue homeostasis, coordination of …

  Authors: Fernando O Martinez, Laura Helming, Siamon Gordon

  Source: Annual review of immunology. 2009

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• Molecular mediators of macrophage fusion.

  Fusion of macrophages leads to the formation of osteoclasts in bone and of multinucleated giant cells in granulomas. The precise function of granuloma…

  Authors: Laura Helming, Siamon Gordon

  Source: Trends in cell biology. 2009 Oct

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• Antigen presentation the macrophage way.

  Multiphoton intravital microscopy of lymph nodes has revolutionized the study of the early events leading to induction of acquired immunity. Using thi…

  Authors: Luisa Martinez-Pomares, Siamon Gordon

  Source: Cell. 2007 Nov 16

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• Pattern recognition receptors: doubling up for the innate immune response.

  Antigen presenting cells (macrophages and dendritic cells) express pattern recognition molecules that are thought to recognize foreign ligands during …

  Authors: Siamon Gordon

  Source: Cell. 2002 Dec 27

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• Dectin-1 is required for beta-glucan recognition and control of fungal infection.

  Beta-glucan is one of the most abundant polysaccharides in fungal pathogens, yet its importance in antifungal immunity is unclear. Here we show that d…

  Authors: Philip R Taylor, S Vicky Tsoni, Janet A Willment, Kevin M Dennehy, Marcela Rosas, Helen Findon, Ken Haynes, Chad Steele, Marina Botto, Siamon Gordon,…

  Source: Nature immunology. 2007 Jan

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• Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion.

  Alternatively activated macrophages play an important role in host defense in the context of a T helper type 2 (Th2) microenvironment such as parasiti…

  Authors: Audrey Varin, Subhankar Mukhopadhyay, Georges Herbein, Siamon Gordon

  Source: Blood. 2010 Jan 14

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• Adhesion-GPCRs: emerging roles for novel receptors.

  The G protein-coupled receptor (GPCR) family comprises the largest class of cell surface receptors found in metazoan proteomes. Within the novel GPCR …

  Authors: Simon Yona, Hsi-Hsien Lin, Willie O Siu, Siamon Gordon, Martin Stacey

  Source: Trends in biochemical sciences. 2008 Oct

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• Dectin-1 escape by fungal dimorphism.

  Candida albicans, a medically important fungus, exists primarily as yeast and filamentous forms. Its cell wall is rich in beta-glucans, which are reco…

  Authors: Sigrid E M Heinsbroek, Gordon D Brown, Siamon Gordon

  Source: Trends in immunology. 2005 Jul

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• Fungal beta-glucans and mammalian immunity.

  Beta-glucans are structural cell wall polymers of many fungi which possess immunomodulatory activities. Although the therapeutic benefits associated w…

  Authors: Gordon D Brown, Siamon Gordon

  Source: Immunity. 2003 Sep

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• Conserved domains of the class A scavenger receptors: evolution and function.

  The class A scavenger receptors are phagocytic pattern recognition receptors that are well represented in vertebrate genomes. The high level of conser…

  Authors: Dawn M E Bowdish, Siamon Gordon

  Source: Immunological reviews. 2009 Jan

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