1 to 10 of 22 literature results

• Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis.

  Tumor cells display progressive changes in metabolism that correlate with malignancy, including development of a lipogenic phenotype. How stored fats …

  Authors: Daniel K Nomura, Jonathan Z Long, Sherry Niessen, Heather S Hoover, Shu-Wing Ng, Benjamin F Cravatt

  Source: Cell. 2010 Jan 8

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• The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.

  Elevations in circulating glucose and gut hormones during feeding promote pancreatic islet cell viability in part via the calcium- and cAMP-dependent …

  Authors: Robert A Screaton, Michael D Conkright, Yoshiko Katoh, Jennifer L Best, Gianluca Canettieri, Shawn Jeffries, Ernesto Guzman, Sherry Niessen, John R Yates, Hiroshi Takemori,…

  Source: Cell. 2004 Oct 1

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• Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor.

  Low-density lipoprotein receptor-related protein (LRP-1) functions in endocytosis and in cell signaling directly (by binding signaling adaptor protein…

  Authors: Alban Gaultier, Sanja Arandjelovic, Sherry Niessen, Cheryl D Overton, MacRae F Linton, Sergio Fazio, W Marie Campana, Benjamin F Cravatt, Steven L Gonias

  Source: Blood. 2008 Jun 1

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• A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.

  Kinetochores play an essential role in chromosome segregation by forming dynamic connections with spindle microtubules. Here, we identify a set of 10 …

  Authors: Iain M Cheeseman, Sherry Niessen, Scott Anderson, Francie Hyndman, John R Yates, Karen Oegema, Arshad Desai

  Source: Genes & development. 2004 Sep 15

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• An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling.

  Hundreds, if not thousands, of uncharacterized enzymes currently populate the human proteome. Assembly of these proteins into the metabolic and signal…

  Authors: Kyle P Chiang, Sherry Niessen, Alan Saghatelian, Benjamin F Cravatt

  Source: Chemistry & biology. 2006 Oct

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• Phosphorylation of the chromosomal passenger protein Bir1 is required for localization of Ndc10 to the spindle during anaphase and full spindle elongation.

  The Saccharomyces cerevisiae inhibitor of apoptosis (IAP) repeat protein Bir1 localizes as a chromosomal passenger. A deletion analysis of Bir1 identi…

  Authors: Per O Widlund, John S Lyssand, Scott Anderson, Sherry Niessen, John R Yates, Trisha N Davis

  Source: Molecular biology of the cell. 2006 Mar

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• Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling.

  The endocannabinoid 2-arachidonoylglycerol (2-AG) has been implicated as a key retrograde mediator in the nervous system based on pharmacological stud…

  Authors: Heather S Hoover, Jacqueline L Blankman, Sherry Niessen, Benjamin F Cravatt

  Source: Bioorganic & medicinal chemistry letters. 2008 Nov 15

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• Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex.

  Schizosaccharomyces pombe Dim1p is required for maintaining the steady-state level of the anaphase-promoting complex or cyclosome (APC/C) component Li…

  Authors: Robert H Carnahan, Anna Feoktistova, Liping Ren, Sherry Niessen, John R Yates, Kathleen L Gould

  Source: Eukaryotic cell. 2005 Mar

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• Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability.

  Accurate control of the number of centrosomes, the major microtubule-organizing centers of animal cells, is critical for the maintenance of genome int…

  Authors: Andrew J Holland, Weijie Lan, Sherry Niessen, Heather Hoover, Don W Cleveland

  Source: The Journal of cell biology. 2010 Jan 25

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• Activity-based probes for monitoring postproline protease activity.

  Postproline proteases constitute a subset of serine proteases involved in the regulation of many signaling events and are emerging as promising therap…

  Authors: Eduard Sabidó, Teresa Tarragó, Sherry Niessen, Benjamin F Cravatt, Ernest Giralt

  Source: Chembiochem : a European journal of chemical biology. 2009 Sep 21

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