1 to 7 of 7 literature results

• Yeast chemical genomics and drug discovery: an update.

  The Saccharomyces cerevisiae sequencing project (the first eukaryotic genome decoded) was completed in 1995 and, subsequently, the first version of th…

  Authors: Shawn Hoon, Robert P St Onge, Guri Giaever, Corey Nislow

  Source: Trends in pharmacological sciences. 2008 Oct

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• Biopipe: a flexible framework for protocol-based bioinformatics analysis.

  We identify several challenges facing bioinformatics analysis today. Firstly, to fulfill the promise of comparative studies, bioinformatics analysis w…

  Authors: Shawn Hoon, Kiran Kumar Ratnapu, Jer-Ming Chia, Balamurugan Kumarasamy, Xiao Juguang, Michele Clamp, Arne Stabenau, Simon Potter, Laura Clarke, Elia Stupka

  Source: Genome research. 2003 Aug

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• Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis.

  BACKGROUND: Single genome-wide screens for the effect of altered gene dosage on drug sensitivity in the model organism Saccharomyces cerevisiae provid…

  Authors: Danielle Kemmer, Lianne M McHardy, Shawn Hoon, Delphine Rebérioux, Guri Giaever, Corey Nislow, Calvin D Roskelley, Michel Roberge

  Source: BMC microbiology. 2009

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• The chemical genomic portrait of yeast: uncovering a phenotype for all genes.

  Genetics aims to understand the relation between genotype and phenotype. However, because complete deletion of most yeast genes ( approximately 80%) h…

  Authors: Maureen E Hillenmeyer, Eula Fung, Jan Wildenhain, Sarah E Pierce, Shawn Hoon, William Lee, Michael Proctor, Robert P St Onge, Mike Tyers, Daphne Koller,…

  Source: Science (New York, N.Y.). 2008 Apr 18

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• An integrated platform of genomic assays reveals small-molecule bioactivities.

  Bioactive compounds are widely used to modulate protein function and can serve as important leads for drug development. Identifying the in vivo target…

  Authors: Shawn Hoon, Andrew M Smith, Iain M Wallace, Sundari Suresh, Molly Miranda, Eula Fung, Michael Proctor, Kevan M Shokat, Chao Zhang, Ronald W Davis,…

  Source: Nature chemical biology. 2008 Aug

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• Variation in sequence and organization of splicing regulatory elements in vertebrate genes.

  Although core mechanisms and machinery of premRNA splicing are conserved from yeast to human, the details of intron recognition often differ, even bet…

  Authors: Gene Yeo, Shawn Hoon, Byrappa Venkatesh, Christopher B Burge

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2004 Nov 2

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• Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes.

  The compact genome of Fugu rubripes has been sequenced to over 95% coverage, and more than 80% of the assembly is in multigene-sized scaffolds. In thi…

  Authors: Samuel Aparicio, Jarrod Chapman, Elia Stupka, Nik Putnam, Jer-Ming Chia, Paramvir Dehal, Alan Christoffels, Sam Rash, Shawn Hoon, Arian Smit,…

  Source: Science (New York, N.Y.). 2002 Aug 23

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