1 to 7 of 7 literature results

• Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.

  Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with he…

  Authors: International Schizophrenia Consortium, Shaun M Purcell, Naomi R Wray, Jennifer L Stone, Peter M Visscher, Michael C O'Donovan, Patrick F Sullivan, Pamela Sklar

  Source: Nature. 2009 Aug 6

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• Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder.

  We present a method for testing overrepresentation of biological pathways, indexed by gene-ontology terms, in lists of significant SNPs from genome-wi…

  Authors: Peter Holmans, Elaine K Green, Jaspreet Singh Pahwa, Manuel A R Ferreira, Shaun M Purcell, Pamela Sklar, Wellcome Trust Case-Control Consortium, Michael J Owen, Michael C O'Donovan, Nick Craddock

  Source: American journal of human genetics. 2009 Jul

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• Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

  To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of stro…

  Authors: Manuel A R Ferreira, Michael C O'Donovan, Yan A Meng, Ian R Jones, Douglas M Ruderfer, Lisa Jones, Jinbo Fan, George Kirov, Roy H Perlis, Elaine K Green,…

  Source: Nature genetics. 2008 Sep

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• Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility.

  BACKGROUND: The DTNBP1 gene, encoding dysbindin, has been strongly implicated in schizophrenia (SZ) susceptibility by a series of independent genetic …

  Authors: Derek W Morris, Kevin Murphy, Niamh Kenny, Shaun M Purcell, Kevin A McGhee, Siobhan Schwaiger, Jeanne-Marie Nangle, Gary Donohoe, Sarah Clarke, Paul Scully,…

  Source: Biological psychiatry. 2008 Jan 1

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• A multivariate test of association.

  Although genetic association studies often test multiple, related phenotypes, few formal multivariate tests of association are available. We describe …

  Authors: Manuel A R Ferreira, Shaun M Purcell

  Source: Bioinformatics (Oxford, England). 2009 Jan 1

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• Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses' Health Study II.

  BACKGROUND: One in nine American women will meet criteria for the diagnosis of posttraumatic stress disorder (PTSD) in their lifetime. Although twin s…

  Authors: Karestan C Koenen, Immaculata De Vivo, Janet Rich-Edwards, Jordan W Smoller, Rosalind J Wright, Shaun M Purcell

  Source: BMC psychiatry. 2009

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• Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

  Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within t…

  Authors: Soumya Raychaudhuri, Robert M Plenge, Elizabeth J Rossin, Aylwin C Y Ng, International Schizophrenia Consortium, Shaun M Purcell, Pamela Sklar, Edward M Scolnick, Ramnik J Xavier, David Altshuler,…

  Source: PLoS genetics. 2009 Jun

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