1 to 7 of 7 literature results

• PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance.

  Macrophages rapidly engulf apoptotic cells to limit the release of noxious cellular contents and to restrict autoimmune responses against self antigen…

  Authors: Lata Mukundan, Justin I Odegaard, Christine R Morel, Jose E Heredia, Julia W Mwangi, Roberto R Ricardo-Gonzalez, Y P Sharon Goh, Alex Red Eagle, Shannon E Dunn, Jennifer U H Awakuni,…

  Source: Nature medicine. 2009 Nov

  View Full Text

• Type II monocytes modulate T cell-mediated central nervous system autoimmune disease.

  Treatment with glatiramer acetate (GA, copolymer-1, Copaxone), a drug approved for multiple sclerosis (MS), in a mouse model promoted development of a…

  Authors: Martin S Weber, Thomas Prod'homme, Sawsan Youssef, Shannon E Dunn, Cynthia D Rundle, Linda Lee, Juan C Patarroyo, Olaf Stüve, Raymond A Sobel, Lawrence Steinman,…

  Source: Nature medicine. 2007 Aug

  View Full Text

• Calcineurin and skeletal muscle growth.

  Authors: Shannon E Dunn, Alain R Simard, Renée A Prud'homme, Robin N Michel

  Source: Nature cell biology. 2002 Mar

  View Full Text

• Statins in the treatment of central nervous system autoimmune disease.

  Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, are widely prescribed for their cholesterol-lowering properties to reduce athe…

  Authors: Martin S Weber, Sawsan Youssef, Shannon E Dunn, Thomas Prod'homme, Oliver Neuhaus, Olaf Stuve, John Greenwood, Lawrence Steinman, Scott S Zamvil

  Source: Journal of neuroimmunology. 2006 Sep

  View Full Text

• Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin.

  3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholestero…

  Authors: Shannon E Dunn, Sawsan Youssef, Matthew J Goldstein, Thomas Prod'homme, Martin S Weber, Scott S Zamvil, Lawrence Steinman

  Source: The Journal of experimental medicine. 2006 Feb 20

  View Free Full Text

• Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity.

  Peroxisome proliferator-activated receptor (PPAR)alpha is a nuclear receptor that mediates gender differences in lipid metabolism. PPARalpha also func…

  Authors: Shannon E Dunn, Shalina S Ousman, Raymond A Sobel, Luis Zuniga, Sergio E Baranzini, Sawsan Youssef, Andrea Crowell, John Loh, Jorge Oksenberg, Lawrence Steinman

  Source: The Journal of experimental medicine. 2007 Feb 19

  View Free Full Text

• Calcineurin and skeletal muscle growth.

  Recruitment determines the profile of fibre-type-specific genes expressed across the range of muscle fibres associated with slow, fast fatigue-resista…

  Authors: Robin N Michel, Shannon E Dunn, Eva R Chin

  Source: The Proceedings of the Nutrition Society. 2004 May

  View Full Text