1 to 10 of 14 literature results

• IL-12p40: an inherently agonistic cytokine.

  IL-12p40 is known as a component of the bioactive cytokines interleukin (IL)-12 and IL-23 but it is not widely recognized as having intrinsic function…

  Authors: Andrea M Cooper, Shabaana A Khader

  Source: Trends in immunology. 2007 Jan

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• Interleukin-12 and tuberculosis: an old story revisited.

  Our understanding of the role of interleukin (IL)-12 in controlling tuberculosis has expanded because of increased interest in other members of the IL…

  Authors: Andrea M Cooper, Alejandra Solache, Shabaana A Khader

  Source: Current opinion in immunology. 2007 Aug

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• IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge.

  Interferon-gamma is key in limiting Mycobacterium tuberculosis infection. Here we show that vaccination triggered an accelerated interferon-gamma resp…

  Authors: Shabaana A Khader, Guy K Bell, John E Pearl, Jeffrey J Fountain, Javier Rangel-Moreno, Garth E Cilley, Fang Shen, Sheri M Eaton, Sarah L Gaffen, Susan L Swain,…

  Source: Nature immunology. 2007 Apr

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• The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis.

  Tuberculosis (TB) results from an interaction between a potent immune response and a chronically persistent pathogen. The ability of Mycobacterium tub…

  Authors: Andrea M Cooper, Shabaana A Khader

  Source: Immunological reviews. 2008 Dec

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• Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis.

  The importance of T helper type 1 (Th1) cell immunity in host resistance to the intracellular bacterium Francisella tularensis is well established. Ho…

  Authors: Yinyao Lin, Shane Ritchea, Alison Logar, Samantha Slight, Michelle Messmer, Javier Rangel-Moreno, Lokesh Guglani, John F Alcorn, Heather Strawbridge, Sang Mi Park,…

  Source: Immunity. 2009 Nov 20

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• IL-23 and IL-17 in tuberculosis.

  Tuberculosis is a chronic disease requiring the constant expression of cellular immunity to limit bacterial growth. The constant expression of immunit…

  Authors: Shabaana A Khader, Andrea M Cooper

  Source: Cytokine. 2008 Feb

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• Th17 cytokines and vaccine-induced immunity.

  T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role…

  Authors: Yinyao Lin, Samantha R Slight, Shabaana A Khader

  Source: Seminars in immunopathology. 2010 Mar

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• In a murine tuberculosis model, the absence of homeostatic chemokines delays granuloma formation and protective immunity.

  Mycobacterium tuberculosis infection (Mtb) results in the generation of protective cellular immunity and formation of granulomatous structures in the …

  Authors: Shabaana A Khader, Javier Rangel-Moreno, Jeffrey J Fountain, Cynthia A Martino, William W Reiley, John E Pearl, Gary M Winslow, David L Woodland, Troy D Randall, Andrea M Cooper

  Source: Journal of immunology (Baltimore, Md. : 1950). 2009 Dec 15

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• Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12R{beta}1 isoform that enhances DC migration.

  RNA splicing is an increasingly recognized regulator of immunity. Here, we demonstrate that after Mycobacterium tuberculosis infection (mRNA) il12rb1 …

  Authors: Richard T Robinson, Shabaana A Khader, Cynthia A Martino, Jeffrey J Fountain, Maria Teixeira-Coelho, John E Pearl, Stephen T Smiley, Gary M Winslow, David L Woodland, Michael J Walter,…

  Source: The Journal of experimental medicine. 2010 Mar 15

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• Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration.

  At the temperature of its flea vector (approximately 20-30 degrees C), the causative agent of plague, Yersinia pestis, expresses a profile of genes di…

  Authors: Richard T Robinson, Shabaana A Khader, Richard M Locksley, Egil Lien, Stephen T Smiley, Andrea M Cooper

  Source: Journal of immunology (Baltimore, Md. : 1950). 2008 Oct 15

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