1 to 10 of 54 literature results

• Angiotensins in Alzheimer's disease - friend or foe?

  The renin-angiotensin system (RAS) is an important regulator of blood pressure. Observational and experimental studies suggest that alterations in blo…

  Authors: Patrick G Kehoe, Scott Miners, Seth Love

  Source: Trends in neurosciences. 2009 Dec

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• Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial.

  BACKGROUND: Immunisation of patients with Alzheimer's disease with full-length amyloid-beta peptide (Abeta(42)) can clear amyloid plaques from the bra…

  Authors: Clive Holmes, Delphine Boche, David Wilkinson, Ghasem Yadegarfar, Vivienne Hopkins, Anthony Bayer, Roy W Jones, Roger Bullock, Seth Love, James W Neal,…

  Source: Lancet. 2008 Jul 19

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• Phosphorylated Smad 2/3 colocalizes with phospho-tau inclusions in Pick disease, progressive supranuclear palsy, and corticobasal degeneration but not with alpha-synuclein inclusions in multiple system atrophy or dementia with Lewy bodies.

  Impaired transduction of transforming growth factor-beta signaling has recently been implicated in Alzheimer disease. Transforming growth factor-beta …

  Authors: Katy A Chalmers, Seth Love

  Source: Journal of neuropathology and experimental neurology. 2007 Nov

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• Neurofibrillary tangles may interfere with Smad 2/3 signaling in neurons.

  Transforming growth factor (TGF)-beta is a multifunctional cytokine with anti-inflammatory, reparative and neuroprotective functions. Increased levels…

  Authors: Katy A Chalmers, Seth Love

  Source: Journal of neuropathology and experimental neurology. 2007 Feb

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• Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.

  We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS…

  Authors: Denise Harold, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Marian L Hamshere, Jaspreet Singh Pahwa, Valentina Moskvina, Kimberley Dowzell, Amy Williams,…

  Source: Nature genetics. 2009 Oct

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• Elevated matrix metalloproteinase-9 and degradation of perineuronal nets in cerebrocortical multiple sclerosis plaques.

  Matrix metalloproteinases (MMPs) degrade extracellular matrix; MMP activity, particularly of MMP-9, is elevated in the white matter in multiple sclero…

  Authors: Elizabeth Gray, Taya Louise Thomas, Samar Betmouni, Neil Scolding, Seth Love

  Source: Journal of neuropathology and experimental neurology. 2008 Sep

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• Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity.

  Experimental reduction of neprilysin (NEP) or insulin-degrading enzyme (IDE) in vivo exacerbates beta-amyloid accumulation in the brain. The level of …

  Authors: James Scott Miners, Shabnam Baig, Hannah Tayler, Patrick Gavin Kehoe, Seth Love

  Source: Journal of neuropathology and experimental neurology. 2009 Aug

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• Loss of Perineuronal Net in ME7 Prion Disease.

  Microglial activation and behavioral abnormalities occur before neuronal loss in experimental murine prion disease; the behavioral changes coincide wi…

  Authors: Sarah L Franklin, Seth Love, J Richard T Greene, Samar Betmouni

  Source: Journal of neuropathology and experimental neurology. 2008 Mar

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• Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer's disease.

  Dietary omega3-polyunsaturated fatty acids are thought to influence the risk of Alzheimer's disease (AD), and supplemental docosahexaenoic acid (DHA; …

  Authors: Thomas Fraser, Hannah Tayler, Seth Love

  Source: Neurochemical research. 2010 Mar

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• Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain.

  Authors: Seth Love, Puneet Plaha, Nikunj K Patel, Gary R Hotton, David J Brooks, Steven S Gill

  Source: Nature medicine. 2005 Jul

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