1 to 10 of 82 literature results

• Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

  Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Stu…

  Authors: Masato Furuhashi, Gürol Tuncman, Cem Z Görgün, Liza Makowski, Genichi Atsumi, Eric Vaillancourt, Keita Kono, Vladimir R Babaev, Sergio Fazio, MacRae F Linton,…

  Source: Nature. 2007 Jun 21

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• Fenofibrate and risk of minor amputations in diabetes.

  Authors: Sergio Fazio, MacRae F Linton

  Source: Lancet. 2009 May 23

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• Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse.

  Macrophage low-density lipoprotein receptor-related protein (LRP) mediates internalization of remnant lipoproteins, and it is generally thought that b…

  Authors: Cheryl D Overton, Patricia G Yancey, Amy S Major, MacRae F Linton, Sergio Fazio

  Source: Circulation research. 2007 Mar 16

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• Lipid-altering efficacy and safety of ezetimibe/simvastatin coadministered with extended-release niacin in patients with type IIa or type IIb hyperlipidemia.

  OBJECTIVES: This study evaluated the safety and lipid-altering efficacy of ezetimibe/simvastatin (E/S) coadministered with extended-release niacin (N)…

  Authors: John R Guyton, B Greg Brown, Sergio Fazio, Adam Polis, Joanne E Tomassini, Andrew M Tershakovec

  Source: Journal of the American College of Cardiology. 2008 Apr 22

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• Management of mixed dyslipidemia in patients with or at risk for cardiovascular disease: a role for combination fibrate therapy.

  BACKGROUND: Lowering low-density lipoprotein cholesterol (LDL-C) is the primary focus of the management of dyslipidemia in patients with or at risk fo…

  Authors: Sergio Fazio

  Source: Clinical therapeutics. 2008 Feb

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• Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor.

  Low-density lipoprotein receptor-related protein (LRP-1) functions in endocytosis and in cell signaling directly (by binding signaling adaptor protein…

  Authors: Alban Gaultier, Sanja Arandjelovic, Sherry Niessen, Cheryl D Overton, MacRae F Linton, Sergio Fazio, W Marie Campana, Benjamin F Cravatt, Steven L Gonias

  Source: Blood. 2008 Jun 1

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• Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.

  BACKGROUND: The peroxisome proliferator-activated receptor-alpha (PPARalpha) plays important roles in lipid metabolism, inflammation, and atherosclero…

  Authors: Vladimir R Babaev, Hiroyuki Ishiguro, Lei Ding, Patricia G Yancey, Dwayne E Dove, William J Kovacs, Clay F Semenkovich, Sergio Fazio, MacRae F Linton

  Source: Circulation. 2007 Sep 18

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• Retention of low-density lipoprotein in atherosclerotic lesions of the mouse: evidence for a role of lipoprotein lipase.

  Direct binding of apolipoprotein (apo)B-containing lipoproteins to proteoglycans is the initiating event in atherosclerosis, but the processes involve…

  Authors: Maria Gustafsson, Malin Levin, Kristina Skålén, Jeanna Perman, Vincent Fridén, Pernilla Jirholt, Sven-Olof Olofsson, Sergio Fazio, MacRae F Linton, Clay F Semenkovich,…

  Source: Circulation research. 2007 Oct 12

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• Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice.

  BACKGROUND: Cyclooxygenase-1 (COX-1) has been implicated in the pathogenesis of atherothrombosis and is expressed by the major cell types of atheroscl…

  Authors: Vladimir R Babaev, Lei Ding, Jeff Reese, Jason D Morrow, Matthew D Breyer, Sudhansu K Dey, Sergio Fazio, MacRae F Linton

  Source: Circulation. 2006 Jan 3

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• Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1.

  BACKGROUND: Macrophage acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) and apolipoprotein E (apoE) have been implicated in regulating cellular c…

  Authors: Yan Ru Su, Dwayne E Dove, Amy S Major, Alyssa H Hasty, Branden Boone, MacRae F Linton, Sergio Fazio

  Source: Circulation. 2005 May 10

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