1 to 3 of 3 literature results

• Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.

  Imatinib mesylate (Gleevec) is a small-molecule inhibitor of the fusion protein Bcr-Abl, the causal agent in chronic myelogenous leukemia. Here we rep…

  Authors: Risto Kerkelä, Luanda Grazette, Rinat Yacobi, Cezar Iliescu, Richard Patten, Cara Beahm, Brian Walters, Sergei Shevtsov, Stéphanie Pesant, Fred J Clubb,…

  Source: Nature medicine. 2006 Aug

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• Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase.

  Certain hydroxylated polychlorinated biphenyls (OH-PCBs) inhibit the human estrogen sulfotransferase (hEST) at subnanomolar concentrations, suggesting…

  Authors: Sergei Shevtsov, Evgeniy V Petrotchenko, Lars C Pedersen, Masahiko Negishi

  Source: Environmental health perspectives. 2003 Jun

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• Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction.

  Estrogen sulfotransferase (EST) transfers the sulfate group from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to estrogenic steroids. Here we report t…

  Authors: Lars C Pedersen, Evgeniy Petrotchenko, Sergei Shevtsov, Masahiko Negishi

  Source: The Journal of biological chemistry. 2002 May 17

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