1 to 10 of 29 literature results

• Myeloid Translocation Gene 16 (MTG16) Interacts with Notch Transcription Complex Components To Integrate Notch Signaling in Hematopoietic Cell Fate Specification.

  The Notch signaling pathway regulates gene expression programs to influence the specification of cell fate in diverse tissues. In response to ligand b…

  Authors: Michael E Engel, Hong N Nguyen, Jolene Mariotti, Aubrey Hunt, Scott W Hiebert

  Source: Molecular and cellular biology. 2010 Apr

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• RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis.

  The 8;21 translocation, which involves the gene encoding the RUNX family DNA-binding transcription factor AML1 (RUNX1) on chromosome 21 and the ETO (M…

  Authors: Ming Yan, Eun-Young Ahn, Scott W Hiebert, Dong-Er Zhang

  Source: Blood. 2009 Jan 22

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• Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control.

  Histone deacetylases (HDACs) are enzymes that modify key residues in histones to regulate chromatin architecture, and they play a vital role in cell s…

  Authors: Srividya Bhaskara, Brenda J Chyla, Joseph M Amann, Sarah K Knutson, David Cortez, Zu-Wen Sun, Scott W Hiebert

  Source: Molecular cell. 2008 Apr 11

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• AML-1 steps up to the platelets.

  Authors: Brenda J Irvin, Scott W Hiebert

  Source: Nature medicine. 2004 Mar

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• Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation.

  While a number of DNA binding transcription factors have been identified that control hematopoietic cell fate decisions, only a limited number of tran…

  Authors: Brenda J Chyla, Isabel Moreno-Miralles, Melissa A Steapleton, Mary Ann Thompson, Srividya Bhaskara, Michael Engel, Scott W Hiebert

  Source: Molecular and cellular biology. 2008 Oct

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• Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription.

  Canonical Wnt signaling is mediated by a molecular "switch" that regulates the transcriptional properties of the T-cell factor (TCF) family of DNA-bin…

  Authors: Amy C Moore, Joseph M Amann, Christopher S Williams, Emilios Tahinci, Tiffany E Farmer, J Andres Martinez, Genyan Yang, K Scott Luce, Ethan Lee, Scott W Hiebert

  Source: Molecular and cellular biology. 2008 Feb

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• Deletion of Mtgr1 sensitizes the colonic epithelium to dextran sodium sulfate-induced colitis.

  BACKGROUND & AIMS: The disruption of homeostasis between proliferation and apoptosis in the colonic epithelium contributes to the pathogenesis of huma…

  Authors: J Andres Martinez, Christopher S Williams, Joseph M Amann, Tiffany C Ellis, Isabel Moreno-Miralles, M Kay Washington, Paul Gregoli, Scott W Hiebert

  Source: Gastroenterology. 2006 Aug

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• The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia.

  The t(8;21) is one of the most frequent chromosomal translocations associated with acute leukemia. This translocation creates a fusion protein consist…

  Authors: Bryan Linggi, Carsten Müller-Tidow, Louis van de Locht, Ming Hu, John Nip, Hubert Serve, Wolfgang E Berdel, Bert van der Reijden, Dawn E Quelle, Janet D Rowley,…

  Source: Nature medicine. 2002 Jul

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• Role of RUNX family members in transcriptional repression and gene silencing.

  RUNX family members are DNA-binding transcription factors that regulate the expression of genes involved in cellular differentiation and cell cycle pr…

  Authors: Kristie L Durst, Scott W Hiebert

  Source: Oncogene. 2004 May 24

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• Cellular stress triggers TEL nuclear export via two genetically separable pathways.

  TEL (translocation ets leukemia, also known as ETV6) is a repressor of transcription that is disrupted by the t(12;21), which is the most frequent chr…

  Authors: Caroline A Hanson, Lauren D Wood, Scott W Hiebert

  Source: Journal of cellular biochemistry. 2008 May 15

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