1 to 10 of 34 literature results

• IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge.

  Interferon-gamma is key in limiting Mycobacterium tuberculosis infection. Here we show that vaccination triggered an accelerated interferon-gamma resp…

  Authors: Shabaana A Khader, Guy K Bell, John E Pearl, Jeffrey J Fountain, Javier Rangel-Moreno, Garth E Cilley, Fang Shen, Sheri M Eaton, Sarah L Gaffen, Susan L Swain,…

  Source: Nature immunology. 2007 Apr

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• Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis.

  The importance of T helper type 1 (Th1) cell immunity in host resistance to the intracellular bacterium Francisella tularensis is well established. Ho…

  Authors: Yinyao Lin, Shane Ritchea, Alison Logar, Samantha Slight, Michelle Messmer, Javier Rangel-Moreno, Lokesh Guglani, John F Alcorn, Heather Strawbridge, Sang Mi Park,…

  Source: Immunity. 2009 Nov 20

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• An overview of IL-17 function and signaling.

  Since the discovery of interferons over 50 years ago, efforts to understand the biochemistry, molecular biology and biological activities of cytokines…

  Authors: Sarah L Gaffen

  Source: Cytokine. 2008 Sep

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• Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis.

  IL-17 and its receptor are founding members of an emerging family of cytokines and receptors with many unique characteristics. IL-17 is produced prima…

  Authors: Sarah L Gaffen

  Source: Arthritis research & therapy. 2004

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• An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals.

  IL-17 and its receptor are founding members of a novel family of inflammatory cytokines. IL-17 plays a pathogenic role in rheumatoid arthritis (RA)-as…

  Authors: Jeffrey J Yu, Matthew J Ruddy, Grace C Wong, Cornelia Sfintescu, Pamela J Baker, Jeffrey B Smith, Richard T Evans, Sarah L Gaffen

  Source: Blood. 2007 May 1

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• A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss.

  Post-menopausal osteoporosis is considered to be an inflammatory process, in which numerous pro-inflammatory and T-cell-derived cytokines play a bone-…

  Authors: Jaya Goswami, Nydiaris Hernández-Santos, Luis A Zuniga, Sarah L Gaffen

  Source: European journal of immunology. 2009 Oct

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• The interleukin-17 receptor plays a gender-dependent role in host protection against Porphyromonas gingivalis-induced periodontal bone loss.

  Interleukin-17 (IL-17) is a proinflammatory cytokine secreted by the newly described CD4(+) Th17 subset, which is distinct from classic Th1 and Th2 li…

  Authors: Jeffrey J Yu, Matthew J Ruddy, Heather R Conti, Kanitsak Boonanantanasarn, Sarah L Gaffen

  Source: Infection and immunity. 2008 Sep

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• IL-17 and the Th17 lineage in systemic lupus erythematosus.

  PURPOSE OF REVIEW: Systemic lupus erythematosus etiology includes both genetic and environmental factors. Evidence suggests that many genetic loci in …

  Authors: Lee Ann Garrett-Sinha, Shinu John, Sarah L Gaffen

  Source: Current opinion in rheumatology. 2008 Sep

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• Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy.

  IL-17 is the defining cytokine of a newly-described "Th17" population that plays critical roles in mediating inflammation and autoimmunity. The IL-17/…

  Authors: Fang Shen, Sarah L Gaffen

  Source: Cytokine. 2008 Feb

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• CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1.

  CARMA1 (also known as CARD11) is a scaffold molecule and contains a caspase-recruitment domain (CARD) and a membrane-associated guanylate kinase-like …

  Authors: Donghai Wang, Reiko Matsumoto, Yun You, Tuanjie Che, Xue-Yan Lin, Sarah L Gaffen, Xin Lin

  Source: Molecular and cellular biology. 2004 Jan

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