1 to 5 of 5 literature results

• Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels.

  Gamma-secretase modulators (GSMs) include selected non-steroidal anti-inflammatory drugs such as flurbiprofen that selectively lowers the neurotoxic a…

  Authors: Samer O Abdul-Hay, Praneeth Edirisinghe, Gregory R J Thatcher

  Source: Journal of neurochemistry. 2009 Nov

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• NO-flurbiprofen reduces amyloid-beta, is neuroprotective in cell culture, and enhances cognition in response to cholinergic blockade.

  The non-steroidal anti-inflammatory drug flurbiprofen is a selective amyloid lowering agent which has been studied clinically in Alzheimer's disease. …

  Authors: Samer O Abdul-Hay, Jia Luo, Rezene T Ashghodom, Gregory R J Thatcher

  Source: Journal of neurochemistry. 2009 Nov

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• Anti-inflammatory, antiproliferative, and cytoprotective activity of NO chimera nitrates of use in cancer chemoprevention.

  Nonsteroidal anti-inflammatory drugs (NSAIDs) have shown promise in colorectal cancer (CRC), but they are compromised by gastrotoxicity. NO-NSAIDs are…

  Authors: Ghenet K Hagos, Samer O Abdul-Hay, Johann Sohn, Praneeth D Edirisinghe, R Esala P Chandrasena, Zhiqiang Wang, Qian Li, Gregory R J Thatcher

  Source: Molecular pharmacology. 2008 Nov

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• Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors.

  A series of transition state analogues of beta-secretases 1 and 2 (BACE1, 2) inhibitors containing fused-ring or biaryl moieties were designed computa…

  Authors: Srinivas Reddy Chirapu, Boobalan Pachaiyappan, Hikmet F Nural, Xin Cheng, Hongbin Yuan, David C Lankin, Samer O Abdul-Hay, Gregory R J Thatcher, Yong Shen, Alan P Kozikowski,…

  Source: Bioorganic & medicinal chemistry letters. 2009 Jan 1

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• Nitrates and NO-NSAIDs in cancer chemoprevention and therapy: in vitro evidence querying the NO donor functionality.

  Properties of the NO-ASA family of NO-donating NSAIDs (NO-NSAIDs), notably NCX 4016 (mNO-ASA) and NCX 4040 (pNO-ASA), reported in more than one hundre…

  Authors: Tareisha Dunlap, Samer O Abdul-Hay, R Esala P Chandrasena, Ghenet K Hagos, Vaishali Sinha, Zhiqiang Wang, Huali Wang, Gregory R J Thatcher

  Source: Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society. 2008 Sep

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