1 to 10 of 39 literature results

• UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.

  The gut-derived hormone ghrelin exerts its effect on the brain by regulating neuronal activity. Ghrelin-induced feeding behaviour is controlled by arc…

  Authors: Zane B Andrews, Zhong-Wu Liu, Nicholas Walllingford, Derek M Erion, Erzsebet Borok, Jeffery M Friedman, Matthias H Tschöp, Marya Shanabrough, Gary Cline, Gerald I Shulman,…

  Source: Nature. 2008 Aug 14

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• Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals.

  Metabolic hormones, such as leptin, alter the input organization of hypothalamic circuits, resulting in increased pro-opiomelanocortin (POMC) tone, fo…

  Authors: Qian Gao, Gabor Mezei, Yongzhan Nie, Yan Rao, Cheol Soo Choi, Ingo Bechmann, Csaba Leranth, Dominique Toran-Allerand, Catherine A Priest, James L Roberts,…

  Source: Nature medicine. 2007 Jan

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• Ghrelin controls hippocampal spine synapse density and memory performance.

  The gut hormone and neuropeptide ghrelin affects energy balance and growth hormone release through hypothalamic action that involves synaptic plastici…

  Authors: Sabrina Diano, Susan A Farr, Stephen C Benoit, Ewan C McNay, Ivaldo da Silva, Balazs Horvath, F Spencer Gaskin, Naoko Nonaka, Laura B Jaeger, William A Banks,…

  Source: Nature neuroscience. 2006 Mar

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• Inverse shift in circulating corticosterone and leptin levels elevates hypothalamic deiodinase type 2 in fasted rats.

  During food deprivation, plasma T(4) and T(3) levels are decreased. Under this metabolic condition, hypothalamic deiodinase type 2 (D2) activity and m…

  Authors: Anna Coppola, Rosaria Meli, Sabrina Diano

  Source: Endocrinology. 2005 Jun

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• The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.

  The gastrointestinal peptide hormone ghrelin stimulates appetite in rodents and humans via hypothalamic actions. We discovered expression of ghrelin i…

  Authors: Michael A Cowley, Roy G Smith, Sabrina Diano, Matthias Tschöp, Nina Pronchuk, Kevin L Grove, Christian J Strasburger, Martin Bidlingmaier, Michael Esterman, Mark L Heiman,…

  Source: Neuron. 2003 Feb 20

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• Suppression of hypothalamic deiodinase type II activity blunts TRH mRNA decline during fasting.

  Fasting is characterized by disrupted thyroid feedback, with suppressed levels of thyroid hormones and paraventricular thyrotropin releasing hormone (…

  Authors: Anna Coppola, Jeniter Hughes, Emanuela Esposito, Luigi Schiavo, Rosaria Meli, Sabrina Diano

  Source: FEBS letters. 2005 Aug 29

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• Fasting activates the nonhuman primate hypocretin (orexin) system and its postsynaptic targets.

  In rodents, hypocretin (HCRT, also called orexin) influences a variety of endocrine, autonomic, and metabolic functions. The present study was underta…

  Authors: Sabrina Diano, Balazs Horvath, Henryk F Urbanski, Peter Sotonyi, Tamas L Horvath

  Source: Endocrinology. 2003 Sep

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• Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector.

  Uncoupling proteins (UCPs) are localized in the inner membrane of the mitochondria in diverse tissues and decrease mitochondrial membrane potential. T…

  Authors: Tamas L Horvath, Sabrina Diano, Colin Barnstable

  Source: Biochemical pharmacology. 2003 Jun 15

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• Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning.

  The mitochondrial uncoupling protein (UCP2) is expressed in selected regions of the brain. Here we demonstrate that up-regulation of UCP2 is part of a…

  Authors: Sabrina Diano, Russell T Matthews, Peter Patrylo, Lichuan Yang, M Flint Beal, Colin J Barnstable, Tamas L Horvath

  Source: Endocrinology. 2003 Nov

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• Type 3 deiodinase in hypoxia: to cool or to kill?

  Type 3 deiodinase (D3) inactivates thyroid hormones. Simonides et al. (2008) now report that hypoxia-induced D3 activation leads to reduction of 3,5,3…

  Authors: Sabrina Diano, Tamas L Horvath

  Source: Cell metabolism. 2008 May

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