1 to 6 of 6 literature results

• The apoptosome activates caspase-9 by dimerization.

  The apical protease of the human intrinsic apoptotic pathway, caspase-9, is activated in a polymeric activation platform known as the apoptosome. The …

  Authors: Cristina Pop, John Timmer, Sabina Sperandio, Guy S Salvesen

  Source: Molecular cell. 2006 Apr 21

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• TOE1 interacts with p53 to modulate its transactivation potential.

  The TOE1 gene was discovered as a target of the Egr1 transcription factor that participates in cell growth regulation through the upregulation of p21 …

  Authors: Sabina Sperandio, Saverio Tardito, Aleksandra Surzycki, Martin Latterich, Ian de Belle

  Source: FEBS letters. 2009 Jul 7

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• A unified model for apical caspase activation.

  Apoptosis is orchestrated by the concerted action of caspases, activated in a minimal two-step proteolytic cascade. Existing data suggests that apical…

  Authors: Kelly M Boatright, Martin Renatus, Fiona L Scott, Sabina Sperandio, Hwain Shin, Irene M Pedersen, Jean Ehrland Ricci, Wade A Edris, Daniel P Sutherlin, Douglas R Green,…

  Source: Molecular cell. 2003 Feb

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• The transcription factor Egr1 regulates the HIF-1alpha gene during hypoxia.

  Using oligonucleotide expression microarrays we have examined the modulation of gene expression in the DU145 prostate cancer cell line. Our findings c…

  Authors: Sabina Sperandio, Jessyka Fortin, Roman Sasik, Lynda Robitaille, Jacques Corbeil, Ian de Belle

  Source: Molecular carcinogenesis. 2009 Jan

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• Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1).

  The type 1 insulin-like growth factor receptor (IGF-IR) is a receptor-tyrosine kinase that plays a critical role in signaling cell survival and prolif…

  Authors: Veronica Galvan, Anna Logvinova, Sabina Sperandio, Hidenori Ichijo, Dale E Bredesen

  Source: The Journal of biological chemistry. 2003 Apr 11

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• In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1.

  Egr1, an immediate early transcription factor, responds to diverse stimuli and affects gene transcription to accomplish its biological effects. One im…

  Authors: Ian De Belle, Jie-Xin Wu, Sabina Sperandio, Dan Mercola, Eileen D Adamson

  Source: The Journal of biological chemistry. 2003 Apr 18

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