1 to 10 of 3,548 literature results

• Toward simpler and faster genome-wide mutagenesis in mice.

  Here we describe a practical Cre-loxP and piggyBac transposon-based mutagenesis strategy to systematically mutate coding sequences and/or the vast non…

  Authors: Sen Wu, Guoxin Ying, Qiang Wu, Mario R Capecchi

  Source: Nature genetics. 2007 Jul

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• Destruction of RhoA CULtivates actin.

  Cullin 3, the core subunit of the CRL3 ubiquitin ligase family, is essential for development, but its substrates remain poorly defined. Here, Chen et …

  Authors: Shuangding Wu, Dieter A Wolf

  Source: Molecular cell. 2009 Sep 24

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• A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses.

  The intestinal flora may promote colon tumor formation. Here we explore immunologic mechanisms of colonic carcinogenesis by a human colonic bacterium,…

  Authors: Shaoguang Wu, Ki-Jong Rhee, Emilia Albesiano, Shervin Rabizadeh, Xinqun Wu, Hung-Rong Yen, David L Huso, Frederick L Brancati, Elizabeth Wick, Florencia McAllister,…

  Source: Nature medicine. 2009 Sep

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• Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors.

  Mutations in the TSC1 and TSC2 tumor suppressor genes give rise to the neoplastic disorders tuberous sclerosis complex (TSC) and lymphangioleiomyomato…

  Authors: Jingxiang Huang, Shulin Wu, Chin-Lee Wu, Brendan D Manning

  Source: Cancer research. 2009 Aug 1

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• The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.

  The Hippo (Hpo) kinase cascade restricts tissue growth by inactivating the transcriptional coactivator Yorkie (Yki), which regulates the expression of…

  Authors: Shian Wu, Yi Liu, Yonggang Zheng, Jixin Dong, Duojia Pan

  Source: Developmental cell. 2008 Mar

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• The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.

  Coordination between cell proliferation and cell death is essential to maintain homeostasis in multicellular organisms. In Drosophila, these two proce…

  Authors: Jianbin Huang, Shian Wu, Jose Barrera, Krista Matthews, Duojia Pan

  Source: Cell. 2005 Aug 12

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• Elucidation of a universal size-control mechanism in Drosophila and mammals.

  Coordination of cell proliferation and cell death is essential to attain proper organ size during development and for maintaining tissue homeostasis t…

  Authors: Jixin Dong, Georg Feldmann, Jianbin Huang, Shian Wu, Nailing Zhang, Sarah A Comerford, Mariana F Gayyed, Robert A Anders, Anirban Maitra, Duojia Pan

  Source: Cell. 2007 Sep 21

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• Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation.

  Cell-extracellular matrix adhesion is an important determinant of cell morphology. We show here that migfilin, a LIM-containing protein, localizes to …

  Authors: Yizeng Tu, Shan Wu, Xiaohua Shi, Ka Chen, Chuanyue Wu

  Source: Cell. 2003 Apr 4

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• The protocadherin gene Celsr3 is required for interneuron migration in the mouse forebrain.

  Interneurons are extremely diverse in the mammalian brain and provide an essential balance for functional neural circuitry. The vast majority of murin…

  Authors: Guoxin Ying, Sen Wu, Ruiqing Hou, Wei Huang, Mario R Capecchi, Qiang Wu

  Source: Molecular and cellular biology. 2009 Jun

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• Loss of YY1 impacts the heterochromatic state and meiotic double-strand breaks during mouse spermatogenesis.

  The progression of spermatogenesis involves global changes in chromatin structure and conformation. However, our understanding of the regulation of ch…

  Authors: Su Wu, Yueh-Chiang Hu, Huifei Liu, Yang Shi

  Source: Molecular and cellular biology. 2009 Dec

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