1 to 10 of 38 literature results

• Regulation of intestinal barrier function by signal transducer and activator of transcription 5b.

  BACKGROUND: Colon epithelial cell (CEC) apoptosis and nuclear factor-kappaB (NF-kappaB) activation may compromise barrier function, and it has been re…

  Authors: X Han, X Ren, I Jurickova, K Groschwitz, B A Pasternak, H Xu, T A Wilson, S P Hogan, L A Denson

  Source: Gut. 2009 Jan

  View Full Text

• A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation.

  Although eosinophils have been implicated in the pathogenesis of gastrointestinal disorders, their function has not been established. Using a murine m…

  Authors: S P Hogan, A Mishra, E B Brandt, M P Royalty, S M Pope, N Zimmermann, P S Foster, M E Rothenberg

  Source: Nature immunology. 2001 Apr

  View Full Text

• FVB/N mice are highly resistant to primary infection with Nippostrongylus brasiliensis.

  Nippostrongylus brasiliensis larvae are particularly susceptible to immunological attack during the pre-lung stage of primary and secondary infections…

  Authors: M L Knott, S P Hogan, H Wang, K I Matthaei, L A Dent

  Source: Parasitology. 2009 Jan

  View Free Full Text

• Review article: The eosinophil as a therapeutic target in gastrointestinal disease.

  Elevated levels of eosinophils in the gastrointestinal tract is a common feature of numerous gastrointestinal disorders including food allergy, parasi…

  Authors: S P Hogan, M E Rothenberg

  Source: Alimentary pharmacology & therapeutics. 2004 Dec

  View Full Text

• Peyer's patch eosinophils: identification, characterization, and regulation by mucosal allergen exposure, interleukin-5, and eotaxin.

  The gastrointestinal immune system is traditionally thought to be composed of lymphocytes located within Peyer's patches and the lamina propria. We ha…

  Authors: A Mishra, S P Hogan, E B Brandt, M E Rothenberg

  Source: Blood. 2000 Aug 15

  View Full Text

• Gastrointestinal eosinophils.

  The gut-associated lymphoid tissue (GALT) is composed of lymphocytes residing in Peyer's patches, lamina propria, and intraepithelial compartments. In…

  Authors: M E Rothenberg, A Mishra, E B Brandt, S P Hogan

  Source: Immunological reviews. 2001 Feb

  View Full Text

• Interleukin-5-producing CD4+ T cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyperreactivity, and lung damage in mice.

  Although activated CD4+ T cells have been implicated in the pathogenesis of asthma, the direct contribution of this leukocyte to the induction of aero…

  Authors: S P Hogan, A Koskinen, K I Matthaei, I G Young, P S Foster

  Source: American journal of respiratory and critical care medicine. 1998 Jan

  View Full Text

• Elemental signals regulating eosinophil accumulation in the lung.

  In this review we identify the elemental signals that regulate eosinophil accumulation in the allergic lung. We show that there are two interwoven mec…

  Authors: P S Foster, A W Mould, M Yang, J Mackenzie, J Mattes, S P Hogan, S Mahalingam, A N Mckenzie, M E Rothenberg, I G Young,…

  Source: Immunological reviews. 2001 Feb

  View Full Text

• Cytokines as targets for the inhibition of eosinophilic inflammation.

  Eosinophilic inflammation is thought to play a central role in the pathogenesis of asthma. The immunoregulatory effects of interleukin (IL)-4, IL-5 an…

  Authors: S P Hogan, P S Foster

  Source: Pharmacology & therapeutics. 1997

  View Full Text

• Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin.

  Interleukin (IL)-13 is a central mediator of the processes underlying the induction of airways hyperreactivity (AHR) in the allergic lung. However, th…

  Authors: M Yang, S P Hogan, P J Henry, K I Matthaei, A N McKenzie, I G Young, M E Rothenberg, P S Foster

  Source: American journal of respiratory cell and molecular biology. 2001 Oct

  View Full Text