1 to 10 of 193 literature results

• The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways.

  The clonal expansion of chronic lymphocytic leukemia (CLL) cells requires the interaction with the microenvironment and is under the control of severa…

  Authors: Daniela de Totero, Raffaella Meazza, Matteo Capaia, Marina Fabbi, Bruno Azzarone, Enrico Balleari, Marco Gobbi, Giovanna Cutrona, Manlio Ferrarini, Silvano Ferrini

  Source: Blood. 2008 Jan 15

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• Human renal cancer cells express a novel membrane-bound interleukin-15 that induces, in response to the soluble interleukin-15 receptor alpha chain, epithelial-to-mesenchymal transition.

  Although interleukin-15 (IL-15) is a powerful immunomodulatory factor that has been proposed for cancer immunotherapy, its intratumoral expression may…

  Authors: Krystel Khawam, Julien Giron-Michel, Yanhong Gu, Aurélie Perier, Massimo Giuliani, Anne Caignard, Aurore Devocelle, Silvano Ferrini, Marina Fabbi, Bernard Charpentier,…

  Source: Cancer research. 2009 Feb 15

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• Heterogeneous expression and function of IL-21R and susceptibility to IL-21-mediated apoptosis in follicular lymphoma cells.

  OBJECTIVE: Interleukin (IL)-21, a member of the IL-2 family, has antitumor activity and is now being tested in non-Hodgkin's lymphoma in combination w…

  Authors: Daniela de Totero, Matteo Capaia, Marina Fabbi, Michela Croce, Raffaella Meazza, Giovanna Cutrona, Simona Zupo, Fabrizio Loiacono, Mauro Truini, Manlio Ferrarini,…

  Source: Experimental hematology. 2010 May

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• Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.

  Activated leukocyte cell adhesion molecule (ALCAM) plays a relevant role in tumor biology and progression. Our previous studies showed that ALCAM is e…

  Authors: Elisa Nuti, Francesca Casalini, Stanislava I Avramova, Salvatore Santamaria, Marina Fabbi, Silvano Ferrini, Luciana Marinelli, Valeria La Pietra, Vittorio Limongelli, Ettore Novellino,…

  Source: Journal of medicinal chemistry. 2010 Mar 25

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• Shed HER2 extracellular domain in HER2-mediated tumor growth and in trastuzumab susceptibility.

  The question of the serum HER2 extracellular domain (HER2/ECD) measurement for prediction of response to the anti-HER2 antibody Trastuzumab is still a…

  Authors: Gaia C Ghedini, Valentina Ciravolo, Monica Tortoreto, Sarah Giuffrè, Francesca Bianchi, Manuela Campiglio, Mimosa Mortarino, Mariangela Figini, Angela Coliva, Maria L Carcangiu,…

  Source: Journal of cellular physiology. 2010 Oct

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• Cancer stem cells: a new paradigm for understanding tumor growth and progression and drug resistance.

  Normal somatic stem cells (SC) are naturally resistant to chemotherapeutic agents due to their expression of various membrane transporter molecules (s…

  Authors: Rosaria Gangemi, Laura Paleari, Anna Maria Orengo, Alfredo Cesario, Leonardo Chessa, Silvano Ferrini, Patrizia Russo

  Source: Current medicinal chemistry. 2009

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• Convenient synthetic approach to 2,4-disubstituted quinazolines.

  reaction: see text] 2,4-Dialkyl or aryl quinazolines have been prepared in three steps starting from easily available anilides. A photochemically indu…

  Authors: Serena Ferrini, Fabio Ponticelli, Maurizio Taddei

  Source: Organic letters. 2007 Jan 4

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• Antimetastatic activity of a preventive cancer vaccine.

  The development of prophylactic cancer vaccines that protect healthy hosts from tumor development leaves open the question whether such vaccines are a…

  Authors: Patrizia Nanni, Giordano Nicoletti, Arianna Palladini, Stefania Croci, Annalisa Murgo, Agnese Antognoli, Lorena Landuzzi, Marina Fabbi, Silvano Ferrini, Piero Musiani,…

  Source: Cancer research. 2007 Nov 15

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• Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells.

  Interleukin-21 (IL-21) is a member of the IL-2 cytokine family, which mediates proliferation or growth arrest and apoptosis of normal B cells, dependi…

  Authors: Daniela de Totero, Raffaella Meazza, Simona Zupo, Giovanna Cutrona, Serena Matis, Monica Colombo, Enrico Balleari, Ivana Pierri, Marina Fabbi, Matteo Capaia,…

  Source: Blood. 2006 May 1

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• NK cells provide helper signal for CD8+ T cells by inducing the expression of membrane-bound IL-15 on DCs.

  NK cell recognition of cells that do not express or express low amounts of MHC class I molecules results not only in direct killing of target cells bu…

  Authors: Barbara Morandi, Lorenzo Mortara, Paolo Carrega, Claudia Cantoni, Gregorio Costa, Roberto S Accolla, Maria Cristina Mingari, Silvano Ferrini, Lorenzo Moretta, Guido Ferlazzo

  Source: International immunology. 2009 May

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