1 to 10 of 31 literature results

• Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation.

  Insulin receptor substrate (IRS)-1 and IRS-2 have dominant roles in the action of insulin, but other substrates of the insulin receptor kinase, such a…

  Authors: Tetsuya Hosooka, Tetsuya Noguchi, Ko Kotani, Takehiro Nakamura, Hiroshi Sakaue, Hiroshi Inoue, Wataru Ogawa, Kazutoshi Tobimatsu, Kazuo Takazawa, Mashito Sakai,…

  Source: Nature medicine. 2008 Feb

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• Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo.

  The transcription factor, signal transducer and activator of transcription-3 (STAT-3) contributes to various physiological processes. Here we show tha…

  Authors: Hiroshi Inoue, Wataru Ogawa, Michitaka Ozaki, Sanae Haga, Michihiro Matsumoto, Kensuke Furukawa, Naoko Hashimoto, Yoshiaki Kido, Toshiyuki Mori, Hiroshi Sakaue,…

  Source: Nature medicine. 2004 Feb

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• Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1.

  Phosphoinositide-dependent kinase-1 (PDK1) is implicated in the metabolic effects of insulin as a key mediator of phosphoinositide 3-kinase-dependent …

  Authors: Yasuo Okamoto, Wataru Ogawa, Akihiko Nishizawa, Hiroshi Inoue, Kiyoshi Teshigawara, Shinichi Kinoshita, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Hiroshi Sakaue,…

  Source: Diabetes. 2007 Apr

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• Establishment of testis-specific SOX9 activation requires high-glucose metabolism in mouse sex differentiation.

  In mouse sex differentiation, SRY promotes Sertoli cell differentiation via SOX9 action, resulting in testis formation. SRY/SOX9 also initiates variou…

  Authors: Shogo Matoba, Ryuji Hiramatsu, Masami Kanai-Azuma, Naoki Tsunekawa, Kyoko Harikae, Hayato Kawakami, Masamichi Kurohmaru, Yoshiakira Kanai

  Source: Developmental biology. 2008 Dec 1

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• Role of the E3 ubiquitin ligase gene related to anergy in lymphocytes in glucose and lipid metabolism in the liver.

  Gene related to anergy in lymphocytes (GRAIL) is an E3 ubiquitin ligase that regulates energy in T-lymphocytes. Whereas, the relevance of GRAIL to T l…

  Authors: Sachie Nakamichi, Yoko Senga, Hiroshi Inoue, Aki Emi, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Wataru Ogawa, Masato Kasuga

  Source: Journal of molecular endocrinology. 2009 Feb

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• Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice.

  Sox7, Sox17 and Sox18 constitute group F of the Sox family of HMG box transcription factor genes. Dominant-negative mutations in Sox18 underlie the ca…

  Authors: Toshiyasu Matsui, Masami Kanai-Azuma, Kenshiro Hara, Shogo Matoba, Ryuji Hiramatsu, Hayato Kawakami, Masamichi Kurohmaru, Peter Koopman, Yoshiakira Kanai

  Source: Journal of cell science. 2006 Sep 1

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• The cerebellin 4 precursor gene is a direct target of SRY and SOX9 in mice.

  In most mammals, the expression of SRY (sex-determining region on the Y chromosome) initiates the development of testes, and thus determines the sex o…

  Authors: Stephen T Bradford, Ryuji Hiramatsu, Madhavi P Maddugoda, Pascal Bernard, Marie-Christine Chaboissier, Andrew Sinclair, Andreas Schedl, Vincent Harley, Yoshiakira Kanai, Peter Koopman,…

  Source: Biology of reproduction. 2009 Jun

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• The Krüppel-like factor KLF15 inhibits transcription of the adrenomedullin gene in adipocytes.

  KLF15 (Krüppel-like factor 15) plays a key role in adipocyte differentiation and glucose transport in adipocytes through activation of its target gene…

  Authors: Tomoki Nagare, Hiroshi Sakaue, Mototsugu Takashima, Kazuhiro Takahashi, Hideyuki Gomi, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Wataru Ogawa, Masato Kasuga

  Source: Biochemical and biophysical research communications. 2009 Jan 30

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• Identification and characterization of an alternative promoter of the human PGC-1alpha gene.

  The transcriptional regulator peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) controls mitochondrial biogenesis and e…

  Authors: Toyo Yoshioka, Kenjiro Inagaki, Tetsuya Noguchi, Mashito Sakai, Wataru Ogawa, Tetsuya Hosooka, Haruhisa Iguchi, Eijiro Watanabe, Yasushi Matsuki, Ryuji Hiramatsu,…

  Source: Biochemical and biophysical research communications. 2009 Apr 17

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• Overexpression of the transcriptional coregulator Cited2 protects against glucocorticoid-induced atrophy of C2C12 myotubes.

  In patients with various catabolic conditions, glucocorticoid excess induces skeletal muscle wasting by accelerating protein degradation via the ubiqu…

  Authors: Kazutoshi Tobimatsu, Tetsuya Noguchi, Tetsuya Hosooka, Mashito Sakai, Kenjiro Inagaki, Yasushi Matsuki, Ryuji Hiramatsu, Masato Kasuga

  Source: Biochemical and biophysical research communications. 2009 Jan 16

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