1 to 10 of 396 literature results

• SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.

  Obesity and metabolic syndrome are increasingly recognized as major risk factors for cardiovascular disease. Herein we show that Krüppel-like transcri…

  Authors: Yumiko Oishi, Ichiro Manabe, Kazuyuki Tobe, Mitsuru Ohsugi, Tetsuya Kubota, Katsuhito Fujiu, Koji Maemura, Naoto Kubota, Takashi Kadowaki, Ryozo Nagai

  Source: Nature medicine. 2008 Jun

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• CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.

  Inflammation is increasingly regarded as a key process underlying metabolic diseases in obese individuals. In particular, obese adipose tissue shows f…

  Authors: Satoshi Nishimura, Ichiro Manabe, Mika Nagasaki, Koji Eto, Hiroshi Yamashita, Mitsuru Ohsugi, Makoto Otsu, Kazuo Hara, Kohjiro Ueki, Seiryo Sugiura,…

  Source: Nature medicine. 2009 Aug

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• A crucial role of a high mobility group protein HMGA2 in cardiogenesis.

  The high mobility group (HMG) of nuclear proteins regulates expression of many genes through architectural remodelling of the chromatin structure, and…

  Authors: Koshiro Monzen, Yuzuru Ito, Atsuhiko T Naito, Hiroki Kasai, Yukio Hiroi, Doubun Hayashi, Ichiro Shiojima, Tsutomu Yamazaki, Kohei Miyazono, Makoto Asashima,…

  Source: Nature cell biology. 2008 May

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• Ultrasound-microbubble-mediated intercellular adhesion molecule-1 small interfering ribonucleic acid transfection attenuates neointimal formation after arterial injury in mice.

  OBJECTIVES: The purpose of this study was to investigate the efficiency of small interfering ribonucleic acid (siRNA) in murine arteries. We transfect…

  Authors: Jun-ichi Suzuki, Masahito Ogawa, Kiyoshi Takayama, Yoshiaki Taniyama, Ryuichi Morishita, Yasunobu Hirata, Ryozo Nagai, Mitsuaki Isobe

  Source: Journal of the American College of Cardiology. 2010 Mar 2

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• Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.

  Adiponectin plays a central role as an antidiabetic and antiatherogenic adipokine. AdipoR1 and AdipoR2 serve as receptors for adiponectin in vitro, an…

  Authors: Toshimasa Yamauchi, Yasunori Nio, Toshiyuki Maki, Masaki Kobayashi, Takeshi Takazawa, Masato Iwabu, Miki Okada-Iwabu, Sachiko Kawamoto, Naoto Kubota, Tetsuya Kubota,…

  Source: Nature medicine. 2007 Mar

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• Periadventitial adipose tissue plays a critical role in vascular remodeling.

  RATIONALE: Obesity is associated with a high incidence of cardiovascular complications. However, the molecular link between obesity and vascular disea…

  Authors: Minoru Takaoka, Daisuke Nagata, Shinji Kihara, Iichiro Shimomura, Yu Kimura, Yasuhiko Tabata, Yoshihiko Saito, Ryozo Nagai, Masataka Sata

  Source: Circulation research. 2009 Oct 23

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• Diverse contribution of bone marrow-derived cells to vascular remodeling associated with pulmonary arterial hypertension and arterial neointimal formation.

  BACKGROUND: Recent evidence suggests that bone marrow (BM)-derived cells may differentiate into vascular cells that participate in arterial repair and…

  Authors: Makoto Sahara, Masataka Sata, Toshihiro Morita, Kazuto Nakamura, Yasunobu Hirata, Ryozo Nagai

  Source: Circulation. 2007 Jan 30

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• Microtubules modulate the stiffness of cardiomyocytes against shear stress.

  Although microtubules are involved in various pathological conditions of the heart including hypertrophy and congestive heart failure, the mechanical …

  Authors: Satoshi Nishimura, Shinya Nagai, Masayoshi Katoh, Hiroshi Yamashita, Yasutake Saeki, Jun-ichi Okada, Toshiaki Hisada, Ryozo Nagai, Seiryo Sugiura

  Source: Circulation research. 2006 Jan 6

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• DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation.

  Alteration in the differentiated state of smooth muscle cells (SMCs) is known to be integral to vascular development and the pathogenesis of vascular …

  Authors: Go Nishimura, Ichiro Manabe, Kensuke Tsushima, Katsuhito Fujiu, Yumiko Oishi, Yasushi Imai, Koji Maemura, Makoto Miyagishi, Yujiro Higashi, Hisato Kondoh,…

  Source: Developmental cell. 2006 Jul

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• Potent inhibitory effect of sirolimus on circulating vascular progenitor cells.

  BACKGROUND: Neointimal hyperplasia is the major cause of in-stent restenosis (ISR). The sirolimus-eluting stent (SES) has emerged as a promising thera…

  Authors: Daiju Fukuda, Masataka Sata, Kimie Tanaka, Ryozo Nagai

  Source: Circulation. 2005 Feb 22

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