1 to 10 of 16 literature results

• Proteomic characterization of the effects of clofibrate on protein expression in rat liver.

  Clofibrate is a peroxisome proliferator known to induce liver tumours in rats. A proteomics study was conducted to provide new insights into the molec…

  Authors: Jean-François Léonard, Martine Courcol, Claire Mariet, Aurore Charbonnier, Eric Boitier, Marc Duchesne, Fabienne Parker, Bruno Genet, Françoise Supatto, Ruth Roberts,…

  Source: Proteomics. 2006 Mar

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• Follicle-stimulating hormone affects metaphase I chromosome alignment and increases aneuploidy in mouse oocytes matured in vitro.

  Follicle-Stimulating Hormone (FSH) at a wide range of doses is routinely added to culture media during in vitro maturation (IVM) of oocytes, but the e…

  Authors: Ruth Roberts, Aikaterini Iatropoulou, Daniel Ciantar, Jaroslav Stark, David L Becker, Stephen Franks, Kate Hardy

  Source: Biology of reproduction. 2005 Jan

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• Early drug safety evaluation: biomarkers, signatures, and fingerprints.

  When target organ toxicity arises in animal models during routine drug safety evaluation, it raises several key questions: Is this target organ toxici…

  Authors: Ruth Roberts, Kelvin Cain, Beth Coyle, Caroline Freathy, Jean-Francois Leonard, Jean-Charles Gautier

  Source: Drug metabolism reviews. 2003 Nov

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• Energy substrate metabolism of mouse cumulus-oocyte complexes: response to follicle-stimulating hormone is mediated by the phosphatidylinositol 3-kinase pathway and is associated with oocyte maturation.

  Successful in vitro maturation (IVM) of oocytes obtained from medium-sized antral follicles could avoid the need for superovulation for in vitro ferti…

  Authors: Ruth Roberts, Jaroslav Stark, Aikaterini Iatropoulou, David L Becker, Stephen Franks, Kate Hardy

  Source: Biology of reproduction. 2004 Jul

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• Cytokines as potential biomarkers of liver toxicity.

  Several important drug classes show pre-clinical hepatotoxicity or, in some cases hepatotoxicity in man in Phase III/IV not predicted by pre-clinical …

  Authors: Sandrine Lacour, Jean-Charles Gautier, Marc Pallardy, Ruth Roberts

  Source: Cancer biomarkers : section A of Disease markers. 2005

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• Mechanistic and epidemiologic data: when is enough enough?

  Authors: Ruth Roberts, John Ashby

  Source: Environmental health perspectives. 2002 Sep

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• Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease.

  Peroxisome proliferator activated receptors (PPARs) are a family of related receptors implicated in a diverse array of biological processes. There are…

  Authors: Eric Boitier, Jean-Charles Gautier, Ruth Roberts

  Source: Comparative hepatology. 2003 Jan 31

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• Gonadotrophin regimens and oocyte quality in women with polycystic ovaries.

  The systemic endocrine environment during the later stages of follicle development has a crucial role in co-ordinating follicular and oocyte maturatio…

  Authors: Stephen Franks, Ruth Roberts, Kate Hardy

  Source: Reproductive biomedicine online. 2003 Mar

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• Proteomic analysis of rodent hepatic responses to peroxisome proliferators.

  Authors: Neil Macdonald, Ruth Roberts

  Source: Methods in enzymology. 2002

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• Tesaglitazar, a PPARalpha/gamma agonist, induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats.

  The development of the dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist tesaglitazar as an oral antidiabetic was recently di…

  Authors: Heike Hellmold, Hui Zhang, Ulf Andersson, Bo Blomgren, Tom Holland, Anna-Lena Berg, Marie Elebring, Niclas Sjögren, Krister Bamberg, Björn Dahl,…

  Source: Toxicological sciences : an official journal of the Society of Toxicology. 2007 Jul

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