1 to 10 of 108 literature results

• PharmGKB: a logical home for knowledge relating genotype to drug response phenotype.

  Authors: Russ B Altman

  Source: Nature genetics. 2007 Apr

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• Challenges for biomedical informatics and pharmacogenomics.

  Pharmacogenomics requires the integration and analysis of genomic, molecular, cellular, and clinical data, and it thus offers a remarkable set of chal…

  Authors: Russ B Altman, Teri E Klein

  Source: Annual review of pharmacology and toxicology. 2002

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• PharmGKB and the International Warfarin Pharmacogenetics Consortium: the changing role for pharmacogenomic databases and single-drug pharmacogenetics.

  PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base (www.pharmgkb.org) is a publicly available online resource dedicated to the dissemi…

  Authors: Ryan P Owen, Russ B Altman, Teri E Klein

  Source: Human mutation. 2008 Apr

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• Finding haplotype tagging SNPs by use of principal components analysis.

  The immense volume and rapid growth of human genomic data, especially single nucleotide polymorphisms (SNPs), present special challenges for both biom…

  Authors: Zhen Lin, Russ B Altman

  Source: American journal of human genetics. 2004 Nov

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• High-throughput single-nucleotide structural mapping by capillary automated footprinting analysis.

  The use of capillary electrophoresis with fluorescently labeled nucleic acids revolutionized DNA sequencing, effectively fueling the genomic revolutio…

  Authors: Somdeb Mitra, Inna V Shcherbakova, Russ B Altman, Michael Brenowitz, Alain Laederach

  Source: Nucleic acids research. 2008 Jun

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• PharmGKB: understanding the effects of individual genetic variants.

  The Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB: http://www.pharmgkb.org) is devoted to disseminating primary data and knowledge in…

  Authors: Katrin Sangkuhl, Dorit S Berlin, Russ B Altman, Teri E Klein

  Source: Drug metabolism reviews. 2008

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• Pharmacogenomics: challenges and opportunities.

  The outcome of drug therapy is often unpredictable, ranging from beneficial effects to lack of efficacy to serious adverse effects. Variations in sing…

  Authors: Dan M Roden, Russ B Altman, Neal L Benowitz, David A Flockhart, Kathleen M Giacomini, Julie A Johnson, Ronald M Krauss, Howard L McLeod, Mark J Ratain, Mary V Relling,…

  Source: Annals of internal medicine. 2006 Nov 21

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• Extracting and characterizing gene-drug relationships from the literature.

  A fundamental task of pharmacogenetics is to collect and classify relationships between genes and drugs. Currently, this useful information has not be…

  Authors: Jeffrey T Chang, Russ B Altman

  Source: Pharmacogenetics. 2004 Sep

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• Large scale study of protein domain distribution in the context of alternative splicing.

  Alternative splicing plays an important role in processes such as development, differentiation and cancer. With the recent increase in the estimates o…

  Authors: Shuo Liu, Russ B Altman

  Source: Nucleic acids research. 2003 Aug 15

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• Predicting allosteric communication in myosin via a pathway of conserved residues.

  We present a computational method that predicts a pathway of residues that mediate protein allosteric communication. The pathway is predicted using on…

  Authors: Susan Tang, Jung-Chi Liao, Alexander R Dunn, Russ B Altman, James A Spudich, Jeanette P Schmidt

  Source: Journal of molecular biology. 2007 Nov 9

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