1 to 10 of 13 literature results

• Vascular smooth muscle overexpression of G protein-coupled receptor kinase 5 elevates blood pressure, which segregates with sex and is dependent on Gi-mediated signaling.

  BACKGROUND: Essential hypertension involves an increase in sympathetic nervous system activity and an associated decrease in beta-adrenergic receptor …

  Authors: Janelle R Keys, Rui-Hai Zhou, David M Harris, Charles A Druckman, Andrea D Eckhart

  Source: Circulation. 2005 Aug 23

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• Vascular endothelial growth factor activation of sterol regulatory element binding protein: a potential role in angiogenesis.

  By stimulating the migration and proliferation of endothelial cells (ECs), vascular endothelial growth factor (VEGF) is a potent angiogenic factor. Ho…

  Authors: Rui-Hai Zhou, Min Yao, Tzong-Shyuan Lee, Yi Zhu, Manuela Martins-Green, John Y-J Shyy

  Source: Circulation research. 2004 Sep 3

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• Enhanced sterol response element-binding protein in postintervention restenotic blood vessels plays an important role in vascular smooth muscle proliferation.

  Postintervention restenosis (PIRS) after balloon angioplasty or stent implantation is a limitation for these interventional procedures even with the a…

  Authors: Rui-Hai Zhou, Stéphanie Pesant, Heather I Cohn, Andrea D Eckhart

  Source: Life sciences. 2008 Jan 16

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• Activation of sterol regulatory element-binding proteins (SREBPs) is critical in IL-8-induced angiogenesis.

  Angiogenesis is essential in many physiological and pathological processes and can be stimulated by many different factors. To better understand and t…

  Authors: Min Yao, Rui-Hai Zhou, Melissa Petreaca, Lei Zheng, John Shyy, Manuela Martins-Green

  Source: Journal of leukocyte biology. 2006 Sep

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• Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells.

  Digitalis has been used to treat congestive heart failure for more than 200 years, although the dual effects (proliferation and death) induced by digi…

  Authors: Jie Qiu, Hai-Qing Gao, Rui-Hai Zhou, Ying Liang, Xu-Hua Zhang, Xu-Ping Wang, Bei-An You, Mei Cheng

  Source: Biological & pharmaceutical bulletin. 2007 Feb

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• Activation of sterol regulatory element binding protein and its involvement in endothelial cell migration

  OBJECTIVE: To study the activation of sterol regulatory element binding protein (SREBP) and its critical role in endothelial cell migration. METHODS: …

  Authors: Ya-bing Ma, Bao-ying Li, Hai-qing Gao, Min Yao, Walter J Koch, Andrea D Eckhart, Rui-hai Zhou

  Source: Zhonghua bing li xue za zhi Chinese journal of pathology. 2009 Jan

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• Comparative proteomics analysis reveals role of heat shock protein 60 in digoxin-induced toxicity in human endothelial cells.

  Although digitalis has been used in clinical treatment extensively, the precise mechanism of its toxic actions on cardiovascular system remained uncle…

  Authors: Jie Qiu, Hai-Qing Gao, Ying Liang, Han Yu, Rui-Hai Zhou

  Source: Biochimica et biophysica acta. 2008 Nov

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• Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction.

  G protein-coupled receptor kinase 2 (GRK2) is a serine/theorinine kinase that phosphorylates and desensitizes agonist-bound G protein-coupled receptor…

  Authors: Heather Irina Cohn, David M Harris, Stephanie Pesant, Michael Pfeiffer, Rui-Hai Zhou, Walter J Koch, Gerald W Dorn, Andrea D Eckhart

  Source: American journal of physiology. Heart and circulatory physiology. 2008 Oct

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• Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart.

  Recent studies from our lab and others have shown that the hematopoietic cytokine erythropoietin (EPO) can protect the heart from ischemic damage in a…

  Authors: Erhe Gao, Matthieu Boucher, J Kurt Chuprun, Rui-Hai Zhou, Andrea D Eckhart, Walter J Koch

  Source: American journal of physiology. Heart and circulatory physiology. 2007 Jul

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• Vascular smooth muscle G(q) signaling is involved in high blood pressure in both induced renal and genetic vascular smooth muscle-derived models of hypertension.

  More than 30% of the US population has high blood pressure (BP), and less than a third of people treated for hypertension have it controlled. In addit…

  Authors: David M Harris, Heather I Cohn, Stéphanie Pesant, Rui-Hai Zhou, Andrea D Eckhart

  Source: American journal of physiology. Heart and circulatory physiology. 2007 Nov

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