1 to 10 of 20 literature results

• Maintenance of serum antibody levels.

  In vertebrates, serum antibodies are an essential component of innate and adaptive immunity and immunological memory. They also can contribute signifi…

  Authors: Rudolf A Manz, Anja E Hauser, Falk Hiepe, Andreas Radbruch

  Source: Annual review of immunology. 2005

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• The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis.

  Autoantibody-mediated diseases like myasthenia gravis, autoimmune hemolytic anemia and systemic lupus erythematosus represent a therapeutic challenge.…

  Authors: Kirsten Neubert, Silke Meister, Katrin Moser, Florian Weisel, Damian Maseda, Kerstin Amann, Carsten Wiethe, Thomas H Winkler, Joachim R Kalden, Rudolf A Manz,…

  Source: Nature medicine. 2008 Jul

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• FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis.

  The survival of long-lived plasma cells, which produce most serum immunoglobulin, is central to humoral immunity. We found here that the inhibitory Fc…

  Authors: Zou Xiang, Antony J Cutler, Rebecca J Brownlie, Kirsten Fairfax, Kate E Lawlor, Eva Severinson, Elizabeth U Walker, Rudolf A Manz, David M Tarlinton, Kenneth G C Smith

  Source: Nature immunology. 2007 Apr

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• Blood-borne human plasma cells in steady state are derived from mucosal immune responses.

  Providing humoral immunity, antibody-secreting plasma cells and their immediate precursors, the plasmablasts, are generated in systemic and mucosal im…

  Authors: Henrik E Mei, Taketoshi Yoshida, Wondossen Sime, Falk Hiepe, Kathi Thiele, Rudolf A Manz, Andreas Radbruch, Thomas Dörner

  Source: Blood. 2009 Mar 12

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• Stromal niches, plasma cell differentiation and survival.

  Contacts made with other cells and stroma have a major impact on proliferation, differentiation, survival, migration and immunoglobulin class switchin…

  Authors: Katrin Moser, Koji Tokoyoda, Andreas Radbruch, Ian MacLennan, Rudolf A Manz

  Source: Current opinion in immunology. 2006 Jun

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• Tolls for B cells.

  Priming of naive lymphocytes is important for yielding efficient immune responses. Mechanisms controlling this process are also important for preventi…

  Authors: Simon Fillatreau, Rudolf A Manz

  Source: European journal of immunology. 2006 Apr

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• Regulation of CXCR3 and CXCR4 expression during terminal differentiation of memory B cells into plasma cells.

  C-X-C motif chemokine receptor 3 (CXCR3) and CXCR4 expressed on immunoglobulin G (IgG)-plasma-cell precursors formed in memory immune responses are cr…

  Authors: Gwendolin Muehlinghaus, Luisa Cigliano, Stephan Huehn, Anette Peddinghaus, Heike Leyendeckers, Anja E Hauser, Falk Hiepe, Andreas Radbruch, Sergio Arce, Rudolf A Manz

  Source: Blood. 2005 May 15

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• Nongenotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma.

  Mutation of p53 is a rare event in multiple myeloma, but it is unknown if p53 signaling is functional in myeloma cells, and if targeted nongenotoxic a…

  Authors: Thorsten Stühmer, Manik Chatterjee, Martin Hildebrandt, Pia Herrmann, Hella Gollasch, Christian Gerecke, Sebastian Theurich, Luisa Cigliano, Rudolf A Manz, Peter T Daniel,…

  Source: Blood. 2005 Nov 15

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• Humoral immunity and long-lived plasma cells.

  A selected fraction of plasmablasts enters the compartment of nondividing, long-lived plasma cells to maintain humoral antibody memory. In accord with…

  Authors: Rudolf A Manz, Sergio Arce, Giuliana Cassese, Anja E Hauser, Falk Hiepe, Andreas Radbruch

  Source: Current opinion in immunology. 2002 Aug

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• VCAM-1-positive stromal cells from human bone marrow producing cytokines for B lineage progenitors and for plasma cells: SDF-1, flt3L, and BAFF.

  The differentiation of B lymphocytes in the bone marrow is guided by the surrounding microenvironment determined by cytokines, adhesion molecules, and…

  Authors: Daniel H S Schaumann, Jens Tuischer, Wolfram Ebell, Rudolf A Manz, Roland Lauster

  Source: Molecular immunology. 2007 Mar

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