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In vertebrates, serum antibodies are an essential component of innate and adaptive immunity and immunological memory. They also can contribute signifi…
Authors: Rudolf A Manz, Anja E Hauser, Falk Hiepe, Andreas Radbruch
Source: Annual review of immunology. 2005
View Full TextAutoantibody-mediated diseases like myasthenia gravis, autoimmune hemolytic anemia and systemic lupus erythematosus represent a therapeutic challenge.…
Authors: Kirsten Neubert, Silke Meister, Katrin Moser, Florian Weisel, Damian Maseda, Kerstin Amann, Carsten Wiethe, Thomas H Winkler, Joachim R Kalden, Rudolf A Manz,…
Source: Nature medicine. 2008 Jul
View Full TextThe survival of long-lived plasma cells, which produce most serum immunoglobulin, is central to humoral immunity. We found here that the inhibitory Fc…
Authors: Zou Xiang, Antony J Cutler, Rebecca J Brownlie, Kirsten Fairfax, Kate E Lawlor, Eva Severinson, Elizabeth U Walker, Rudolf A Manz, David M Tarlinton, Kenneth G C Smith
Source: Nature immunology. 2007 Apr
View Full TextProviding humoral immunity, antibody-secreting plasma cells and their immediate precursors, the plasmablasts, are generated in systemic and mucosal im…
Authors: Henrik E Mei, Taketoshi Yoshida, Wondossen Sime, Falk Hiepe, Kathi Thiele, Rudolf A Manz, Andreas Radbruch, Thomas Dörner
Source: Blood. 2009 Mar 12
View Full TextContacts made with other cells and stroma have a major impact on proliferation, differentiation, survival, migration and immunoglobulin class switchin…
Authors: Katrin Moser, Koji Tokoyoda, Andreas Radbruch, Ian MacLennan, Rudolf A Manz
Source: Current opinion in immunology. 2006 Jun
View Full TextPriming of naive lymphocytes is important for yielding efficient immune responses. Mechanisms controlling this process are also important for preventi…
Authors: Simon Fillatreau, Rudolf A Manz
Source: European journal of immunology. 2006 Apr
View Full TextC-X-C motif chemokine receptor 3 (CXCR3) and CXCR4 expressed on immunoglobulin G (IgG)-plasma-cell precursors formed in memory immune responses are cr…
Authors: Gwendolin Muehlinghaus, Luisa Cigliano, Stephan Huehn, Anette Peddinghaus, Heike Leyendeckers, Anja E Hauser, Falk Hiepe, Andreas Radbruch, Sergio Arce, Rudolf A Manz
Source: Blood. 2005 May 15
View Full TextMutation of p53 is a rare event in multiple myeloma, but it is unknown if p53 signaling is functional in myeloma cells, and if targeted nongenotoxic a…
Authors: Thorsten Stühmer, Manik Chatterjee, Martin Hildebrandt, Pia Herrmann, Hella Gollasch, Christian Gerecke, Sebastian Theurich, Luisa Cigliano, Rudolf A Manz, Peter T Daniel,…
Source: Blood. 2005 Nov 15
View Full TextA selected fraction of plasmablasts enters the compartment of nondividing, long-lived plasma cells to maintain humoral antibody memory. In accord with…
Authors: Rudolf A Manz, Sergio Arce, Giuliana Cassese, Anja E Hauser, Falk Hiepe, Andreas Radbruch
Source: Current opinion in immunology. 2002 Aug
View Full TextThe differentiation of B lymphocytes in the bone marrow is guided by the surrounding microenvironment determined by cytokines, adhesion molecules, and…
Authors: Daniel H S Schaumann, Jens Tuischer, Wolfram Ebell, Rudolf A Manz, Roland Lauster
Source: Molecular immunology. 2007 Mar
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