1 to 10 of 100 literature results

• Staying the distance: avoiding the proteasomal trap.

  There are a multitude of nuclear receptor coactivators, and as a result, individual constituents of activation complexes are often overlooked when stu…

  Authors: Michael Downes, Ronald M Evans

  Source: Cancer cell. 2008 Mar

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• A role for adult TLX-positive neural stem cells in learning and behaviour.

  Neurogenesis persists in the adult brain and can be regulated by a plethora of external stimuli, such as learning, memory, exercise, environment and s…

  Authors: Chun-Li Zhang, Yuhua Zou, Weimin He, Fred H Gage, Ronald M Evans

  Source: Nature. 2008 Feb 21

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• PPAR-gamma regulates osteoclastogenesis in mice.

  Osteoclasts are bone-resorbing cells derived from hematopoietic precursors of the monocyte-macrophage lineage. Regulation of osteoclast function is ce…

  Authors: Yihong Wan, Ling-Wa Chong, Ronald M Evans

  Source: Nature medicine. 2007 Dec

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• PPARs and the complex journey to obesity.

  Obesity and the related disorders of dyslipidemia and diabetes (components of syndrome X) have become global health epidemics. Over the past decade, t…

  Authors: Ronald M Evans, Grant D Barish, Yong-Xu Wang

  Source: Nature medicine. 2004 Apr

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• Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal.

  The nuclear receptor TLX (also known as NR2E1) is essential for adult neural stem cell self-renewal; however, the molecular mechanisms involved remain…

  Authors: Qiuhao Qu, Guoqiang Sun, Wenwu Li, Su Yang, Peng Ye, Chunnian Zhao, Ruth T Yu, Fred H Gage, Ronald M Evans, Yanhong Shi

  Source: Nature cell biology. 2010 Jan

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• Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance.

  Glucose flux through the hexosamine biosynthetic pathway leads to the post-translational modification of cytoplasmic and nuclear proteins by O-linked …

  Authors: Xiaoyong Yang, Pat P Ongusaha, Philip D Miles, Joyce C Havstad, Fengxue Zhang, W Venus So, Jeffrey E Kudlow, Robert H Michell, Jerrold M Olefsky, Seth J Field,…

  Source: Nature. 2008 Feb 21

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• A nuclear strike against Listeria--the evolving life of LXR.

  LXRs are members of the nuclear receptor superfamily and function as master regulators of cholesterol metabolism. In the macrophage, they control chol…

  Authors: Grant D Barish, Ronald M Evans

  Source: Cell. 2004 Oct 15

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• The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export.

  Spt6 promotes transcription elongation at many genes and functions as a histone H3 chaperone to alter chromatin structure during transcription. We sho…

  Authors: Sunnie M Yoh, Helen Cho, Loni Pickle, Ronald M Evans, Katherine A Jones

  Source: Genes & development. 2007 Jan 15

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• Nuclear receptor expression links the circadian clock to metabolism.

  As sensors for fat-soluble hormones and dietary lipids, oscillations in nuclear receptor (NR) expression in key metabolic tissues may contribute to ci…

  Authors: Xiaoyong Yang, Michael Downes, Ruth T Yu, Angie L Bookout, Weimin He, Marty Straume, David J Mangelsdorf, Ronald M Evans

  Source: Cell. 2006 Aug 25

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• Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network.

  In multicellular organisms, the ability to regulate reproduction, development, and nutrient utilization coincided with the evolution of nuclear recept…

  Authors: Angie L Bookout, Yangsik Jeong, Michael Downes, Ruth T Yu, Ronald M Evans, David J Mangelsdorf

  Source: Cell. 2006 Aug 25

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