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There are a multitude of nuclear receptor coactivators, and as a result, individual constituents of activation complexes are often overlooked when stu…
Authors: Michael Downes, Ronald M Evans
Source: Cancer cell. 2008 Mar
View Full TextNeurogenesis persists in the adult brain and can be regulated by a plethora of external stimuli, such as learning, memory, exercise, environment and s…
Authors: Chun-Li Zhang, Yuhua Zou, Weimin He, Fred H Gage, Ronald M Evans
Source: Nature. 2008 Feb 21
View Full TextOsteoclasts are bone-resorbing cells derived from hematopoietic precursors of the monocyte-macrophage lineage. Regulation of osteoclast function is ce…
Authors: Yihong Wan, Ling-Wa Chong, Ronald M Evans
Source: Nature medicine. 2007 Dec
View Full TextObesity and the related disorders of dyslipidemia and diabetes (components of syndrome X) have become global health epidemics. Over the past decade, t…
Authors: Ronald M Evans, Grant D Barish, Yong-Xu Wang
Source: Nature medicine. 2004 Apr
View Full TextThe nuclear receptor TLX (also known as NR2E1) is essential for adult neural stem cell self-renewal; however, the molecular mechanisms involved remain…
Authors: Qiuhao Qu, Guoqiang Sun, Wenwu Li, Su Yang, Peng Ye, Chunnian Zhao, Ruth T Yu, Fred H Gage, Ronald M Evans, Yanhong Shi
Source: Nature cell biology. 2010 Jan
View Full TextGlucose flux through the hexosamine biosynthetic pathway leads to the post-translational modification of cytoplasmic and nuclear proteins by O-linked …
Authors: Xiaoyong Yang, Pat P Ongusaha, Philip D Miles, Joyce C Havstad, Fengxue Zhang, W Venus So, Jeffrey E Kudlow, Robert H Michell, Jerrold M Olefsky, Seth J Field,…
Source: Nature. 2008 Feb 21
View Full TextLXRs are members of the nuclear receptor superfamily and function as master regulators of cholesterol metabolism. In the macrophage, they control chol…
Authors: Grant D Barish, Ronald M Evans
Source: Cell. 2004 Oct 15
View Full TextSpt6 promotes transcription elongation at many genes and functions as a histone H3 chaperone to alter chromatin structure during transcription. We sho…
Authors: Sunnie M Yoh, Helen Cho, Loni Pickle, Ronald M Evans, Katherine A Jones
Source: Genes & development. 2007 Jan 15
View Free Full TextAs sensors for fat-soluble hormones and dietary lipids, oscillations in nuclear receptor (NR) expression in key metabolic tissues may contribute to ci…
Authors: Xiaoyong Yang, Michael Downes, Ruth T Yu, Angie L Bookout, Weimin He, Marty Straume, David J Mangelsdorf, Ronald M Evans
Source: Cell. 2006 Aug 25
View Full TextIn multicellular organisms, the ability to regulate reproduction, development, and nutrient utilization coincided with the evolution of nuclear recept…
Authors: Angie L Bookout, Yangsik Jeong, Michael Downes, Ruth T Yu, Ronald M Evans, David J Mangelsdorf
Source: Cell. 2006 Aug 25
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