1 to 10 of 51 literature results

• Ephs and ephrins keep pancreatic Beta cells connected.

  How insulin-secreting beta cells of the pancreas communicate with each other is largely unknown. In this issue of Cell, Konstantinova et al. (2007) sh…

  Authors: Rohit N Kulkarni, C Ronald Kahn

  Source: Cell. 2007 Apr 20

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• New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.

  Adipose tissue is central to the regulation of energy balance. Two functionally different types of fat are present in mammals: white adipose tissue, t…

  Authors: Yu-Hua Tseng, Efi Kokkotou, Tim J Schulz, Tian Lian Huang, Jonathon N Winnay, Cullen M Taniguchi, T Thien Tran, Ryo Suzuki, Daniel O Espinoza, Yuji Yamamoto,…

  Source: Nature. 2008 Aug 21

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• Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.

  Insulin and insulin-like growth factor I (IGF-I) are ubiquitous hormones that regulate growth and metabolism of most mammalian cells, including pancre…

  Authors: Anke Assmann, Kohjiro Ueki, Jonathon N Winnay, Takahashi Kadowaki, Rohit N Kulkarni

  Source: Molecular and cellular biology. 2009 Jun

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• Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.

  beta cell dysfunction is a central component of the pathogenesis of type 2 diabetes. Using oligonucleotide microarrays and real-time PCR of pancreatic…

  Authors: Jenny E Gunton, Rohit N Kulkarni, SunHee Yim, Terumasa Okada, Wayne J Hawthorne, Yu-Hua Tseng, Russell S Roberson, Camillo Ricordi, Philip J O'Connell, Frank J Gonzalez,…

  Source: Cell. 2005 Aug 12

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• Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.

  An appropriate beta cell mass is pivotal for the maintenance of glucose homeostasis. Both insulin and IGF-1 are important in regulation of beta cell g…

  Authors: Kohjiro Ueki, Terumasa Okada, Jiang Hu, Chong Wee Liew, Anke Assmann, Gabriella M Dahlgren, Jennifer L Peters, Jonathan G Shackman, Min Zhang, Isabella Artner,…

  Source: Nature genetics. 2006 May

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• Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth.

  OBJECTIVE: Phogrin and IA-2, autoantigens in insulin-dependent diabetes, have been shown to be involved in insulin secretion in pancreatic beta-cells;…

  Authors: Seiji Torii, Naoya Saito, Ayumi Kawano, Ni Hou, Kohjiro Ueki, Rohit N Kulkarni, Toshiyuki Takeuchi

  Source: Diabetes. 2009 Mar

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• Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells.

  OBJECTIVE: Calcium-permeable cation channel TRPV2 is expressed in pancreatic beta-cells. We investigated regulation and function of TRPV2 in beta-cell…

  Authors: Etsuko Hisanaga, Masahiro Nagasawa, Kohjiro Ueki, Rohit N Kulkarni, Masatomo Mori, Itaru Kojima

  Source: Diabetes. 2009 Jan

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• Mouse-specific tandem IgY7-SuperMix immunoaffinity separations for improved LC-MS/MS coverage of the plasma proteome.

  We report on a mouse specific SuperMix immunoaffinity separation system for separating low-abundance proteins from high and moderate abundance protein…

  Authors: Jian-Ying Zhou, Brianne O Petritis, Konstantinos Petritis, Angela D Norbeck, Karl K Weitz, Ronald J Moore, David G Camp, Rohit N Kulkarni, Richard D Smith, Wei-Jun Qian

  Source: Journal of proteome research. 2009 Nov

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• Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion.

  To investigate if intracellular glycerol content plays a role in the regulation of insulin secretion in pancreatic beta cells, we studied the expressi…

  Authors: Kazuhiro Matsumura, Benny Hung-Junn Chang, Mineko Fujimiya, Weiqin Chen, Rohit N Kulkarni, Yutaka Eguchi, Hiroshi Kimura, Hideto Kojima, Lawrence Chan

  Source: Molecular and cellular biology. 2007 Sep

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• Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism.

  OBJECTIVE: Liver-specific inactivation of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) by a dominant-negative transgene (l-SACC…

  Authors: Anthony M DeAngelis, Garrett Heinrich, Tong Dai, Thomas A Bowman, Payal R Patel, Sang Jun Lee, Eun-Gyoung Hong, Dae Young Jung, Anke Assmann, Rohit N Kulkarni,…

  Source: Diabetes. 2008 Sep

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