1 to 10 of 26 literature results

• The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway.

  In Saccharomyces cerevisiae, the Rho-type GTPase Cdc42 regulates polarized growth through its effectors, including the p21-activated kinases (PAKs) St…

  Authors: Meng Lin, Heike Unden, Nicolas Jacquier, Roger Schneiter, Ursula Just, Thomas Höfken

  Source: Molecular biology of the cell. 2009 Nov

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• Integral membrane proteins Brr6 and Apq12 link assembly of the nuclear pore complex to lipid homeostasis in the endoplasmic reticulum.

  Cells of Saccharomyces cerevisiae lacking Apq12, a nuclear envelope (NE)-endoplasmic reticulum (ER) integral membrane protein, are defective in assemb…

  Authors: Christine A Hodg, Vineet Choudhary, Michael J Wolyniak, John J Scarcelli, Roger Schneiter, Charles N Col

  Source: Journal of cell science. 2010 Jan 1

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• Intracellular sterol transport in eukaryotes, a connection to mitochondrial function?

  Eukaryotic cells synthesize sterols in the endoplasmatic reticulum (ER) from where it needs to be efficiently transported to the plasma membrane, whic…

  Authors: Roger Schneiter

  Source: Biochimie. 2007 Feb

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• Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation.

  Mitochondrial outer membrane permeabilization (MOMP) is a critical step in apoptosis and is regulated by Bcl-2 family proteins. In vitro systems using…

  Authors: Blanca Schafer, Joel Quispe, Vineet Choudhary, Jerry E Chipuk, Teddy G Ajero, Han Du, Roger Schneiter, Tomomi Kuwana

  Source: Molecular biology of the cell. 2009 Apr

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• Lipid-dependent surface transport of the proton pumping ATPase: a model to study plasma membrane biogenesis in yeast.

  The proton pumping H+-ATPase, Pma1, is one of the most abundant integral membrane proteins of the yeast plasma membrane. Pma1 activity controls the in…

  Authors: Alexandre Toulmay, Roger Schneiter

  Source: Biochimie. 2007 Feb

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• A genomewide screen reveals a role of mitochondria in anaerobic uptake of sterols in yeast.

  The mechanisms that govern intracellular transport of sterols in eukaryotic cells are not well understood. Saccharomyces cerevisiae is a facultative a…

  Authors: Sonja Reiner, Delphine Micolod, Günther Zellnig, Roger Schneiter

  Source: Molecular biology of the cell. 2006 Jan

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• The Saccharomyces cerevisiae YLL012/YEH1, YLR020/YEH2, and TGL1 genes encode a novel family of membrane-anchored lipases that are required for steryl ester hydrolysis.

  Sterol homeostasis in eukaryotic cells relies on the reciprocal interconversion of free sterols and steryl esters. The formation of steryl esters is w…

  Authors: René Köffel, Rashi Tiwari, Laurent Falquet, Roger Schneiter

  Source: Molecular and cellular biology. 2005 Mar

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• Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane.

  Bcl-2 family proteins regulate the release of proteins like cytochrome c from mitochondria during apoptosis. We used cell-free systems and ultimately …

  Authors: Tomomi Kuwana, Mason R Mackey, Guy Perkins, Mark H Ellisman, Martin Latterich, Roger Schneiter, Douglas R Green, Donald D Newmeyer

  Source: Cell. 2002 Nov 1

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• Yeh1 constitutes the major steryl ester hydrolase under heme-deficient conditions in Saccharomyces cerevisiae.

  Steryl esters are stored in intracellular lipid droplets from which they are mobilized upon demand and hydrolyzed to yield free sterols and fatty acid…

  Authors: René Köffel, Roger Schneiter

  Source: Eukaryotic cell. 2006 Jul

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• The role of lipids in the biogenesis of integral membrane proteins.

  Most integral membrane proteins are cotranslationally inserted into the lipid bilayer. In prokaryotes, membrane insertion of the nascent chain takes p…

  Authors: Roger Schneiter, Alexandre Toulmay

  Source: Applied microbiology and biotechnology. 2007 Jan

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