1 to 10 of 117 literature results

• Choreography of MAGUKs during T cell activation.

  T cell receptor activation requires the membrane-associated guanylate kinase CARMA1. A new study finds that a second such kinase, Dlgh1, is also requi…

  Authors: Mercedes Rincón, Roger J Davis

  Source: Nature immunology. 2007 Feb

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• Induction of hepatitis by JNK-mediated expression of TNF-alpha.

  The c-Jun NH(2)-terminal kinase (JNK) signaling pathway has been implicated in the development of tumor necrosis factor (TNF)-dependent hepatitis. JNK…

  Authors: Madhumita Das, Guadalupe Sabio, Feng Jiang, Mercedes Rincón, Richard A Flavell, Roger J Davis

  Source: Cell. 2009 Jan 23

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• Proteins kinases: chromatin-associated enzymes?

  Protein kinases contribute to the regulation of gene expression by interacting with transcription factors that are recruited to the regulatory regions…

  Authors: Chi-Wing Chow, Roger J Davis

  Source: Cell. 2006 Dec 1

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• The JNK signal transduction pathway.

  The c-Jun NH(2)-terminal kinases (JNKs) are an evolutionarily conserved sub-group of mitogen-activated protein (MAP) kinases. Recent studies have impr…

  Authors: Claire R Weston, Roger J Davis

  Source: Current opinion in cell biology. 2007 Apr

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• c-Jun NH2-terminal kinase is required for lineage-specific differentiation but not stem cell self-renewal.

  The c-Jun NH(2)-terminal kinase (JNK) is implicated in proliferation. Mice with a deficiency of either the Jnk1 or the Jnk2 genes are viable, but a co…

  Authors: Ping Xu, Roger J Davis

  Source: Molecular and cellular biology. 2010 Mar

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• Metabolic stress signaling mediated by mixed-lineage kinases.

  Saturated free fatty acid (FFA) is a major source of metabolic stress that activates the c-Jun NH(2)-terminal kinase (JNK). This FFA-stimulated JNK pa…

  Authors: Anja Jaeschke, Roger J Davis

  Source: Molecular cell. 2007 Aug 3

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• A radical role for p38 MAPK in tumor initiation.

  It is established that p38 MAPK can negatively regulate tumorigenesis, but the mechanism is incompletely understood. A new study in this issue of Canc…

  Authors: Norman J Kennedy, Cristina Cellurale, Roger J Davis

  Source: Cancer cell. 2007 Feb

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• MAP kinases in the immune response.

  MAP kinases are among the most ancient signal transduction pathways and are widely used throughout evolution in many physiological processes. In mamma…

  Authors: Chen Dong, Roger J Davis, Richard A Flavell

  Source: Annual review of immunology. 2002

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• Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1.

  The cJun N-terminal kinase 1 (JNK1) is implicated in diet-induced obesity. Indeed, germline ablation of the murine Jnk1 gene prevents diet-induced obe…

  Authors: Guadalupe Sabio, Julie Cavanagh-Kyros, Tamera Barrett, Dae Young Jung, Hwi Jin Ko, Helena Ong, Caroline Morel, Alfonso Mora, Judith Reilly, Jason K Kim,…

  Source: Genes & development. 2010 Feb 1

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• Multisite phosphorylation regulates Bim stability and apoptotic activity.

  The proapoptotic BH3-only protein Bim is established to be an important mediator of signaling pathways that induce cell death. Multisite phosphorylati…

  Authors: Anette Hübner, Tamera Barrett, Richard A Flavell, Roger J Davis

  Source: Molecular cell. 2008 May 23

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