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T cell receptor activation requires the membrane-associated guanylate kinase CARMA1. A new study finds that a second such kinase, Dlgh1, is also requi…
Authors: Mercedes Rincón, Roger J Davis
Source: Nature immunology. 2007 Feb
View Full TextThe c-Jun NH(2)-terminal kinase (JNK) signaling pathway has been implicated in the development of tumor necrosis factor (TNF)-dependent hepatitis. JNK…
Authors: Madhumita Das, Guadalupe Sabio, Feng Jiang, Mercedes Rincón, Richard A Flavell, Roger J Davis
Source: Cell. 2009 Jan 23
View Full TextThe c-Jun NH(2)-terminal kinases (JNKs) are an evolutionarily conserved sub-group of mitogen-activated protein (MAP) kinases. Recent studies have impr…
Authors: Claire R Weston, Roger J Davis
Source: Current opinion in cell biology. 2007 Apr
View Full TextProtein kinases contribute to the regulation of gene expression by interacting with transcription factors that are recruited to the regulatory regions…
Authors: Chi-Wing Chow, Roger J Davis
Source: Cell. 2006 Dec 1
View Full TextSaturated free fatty acid (FFA) is a major source of metabolic stress that activates the c-Jun NH(2)-terminal kinase (JNK). This FFA-stimulated JNK pa…
Authors: Anja Jaeschke, Roger J Davis
Source: Molecular cell. 2007 Aug 3
View Free Full TextMAP kinases are among the most ancient signal transduction pathways and are widely used throughout evolution in many physiological processes. In mamma…
Authors: Chen Dong, Roger J Davis, Richard A Flavell
Source: Annual review of immunology. 2002
View Full TextIt is established that p38 MAPK can negatively regulate tumorigenesis, but the mechanism is incompletely understood. A new study in this issue of Canc…
Authors: Norman J Kennedy, Cristina Cellurale, Roger J Davis
Source: Cancer cell. 2007 Feb
View Full TextThe proapoptotic BH3-only protein Bim is established to be an important mediator of signaling pathways that induce cell death. Multisite phosphorylati…
Authors: Anette Hübner, Tamera Barrett, Richard A Flavell, Roger J Davis
Source: Molecular cell. 2008 May 23
View Free Full TextThe mechanism of apoptotic signaling by JNK is incompletely understood. In the July 7 issue of Molecular Cell, Lu et al. (2006) report that JNK phosph…
Authors: Hayla K Sluss, Roger J Davis
Source: Molecular cell. 2006 Jul 21
View Full TextActivation of immune cells to mediate an immune response is often triggered by potential 'danger' or 'stress' stimuli that the organism receives. With…
Authors: Mercedes Rincón, Roger J Davis
Source: Immunological reviews. 2009 Mar
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