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The optimization and validation of the glycoprotein ELISA assay for quantitative varicella-zoster virus (VZV) antibody detection.
Varicella is a highly contagious viral disease found throughout the world. A live-attenuated Varicella-Zoster virus (VZV) vaccine (Oka/Merck strain), …
Authors: Olivia Hammond, Yue Wang, Tina Green, Joseph Antonello, Robert Kuhn, Clifford Motley, Philip Stump, Beverly Rich, Narendra Chirmule, Rocio D Marchese
Source: Journal of medical virology. 2006 Dec
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Complexities of clinical assay development and optimization prior to first-in-man immunization trials - a description of immunogenicity assay development for the testing of samples from a phase 1 Alzheimer's vaccine trial.
Immunogenicity is often a critical clinical endpoint in the assessment of vaccines prior to the submission of data to regulatory agencies. As a result…
Authors: Olivia Hammond, James Reynolds, Leonard J Rubinstein, Daniel Sikkema, Rocio D Marchese
Source: Journal of immunoassay & immunochemistry. 2008
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Memory T cells and vaccines.
T lymphocytes play a central role in the generation of a protective immune response in many microbial infections. After immunization, dendritic cells …
Authors: Mark T Esser, Rocio D Marchese, Lisa S Kierstead, Lynda G Tussey, Fubao Wang, Narendra Chirmule, Michael W Washabaugh
Source: Vaccine. 2003 Jan 17
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Safety and antibody response, including antibody persistence for 5 years, after primary vaccination or revaccination with pneumococcal polysaccharide vaccine in middle-aged and older adults.
BACKGROUND: This study assessed antibody levels for 5 years after primary vaccination or revaccination with 23-valent pneumococcal polysaccharide vacc…
Authors: Daniel M Musher, Susan B Manof, Charlie Liss, Richard D McFetridge, Rocio D Marchese, Bonnie Bushnell, Frances Alvarez, Carla Painter, Michael D Blum, Jeffrey L Silber
Source: The Journal of infectious diseases. 2010 Feb 15
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Revaccination with a 23-valent pneumococcal polysaccharide vaccine induces elevated and persistent functional antibody responses in adults aged 65 > or = years.
BACKGROUND: Older adults are at high risk of developing invasive pneumococcal disease, but the optimal timing and number of vaccine doses needed to pr…
Authors: Susan B Manoff, Charles Liss, Michael J Caulfield, Rocio D Marchese, Jeffrey Silber, John Boslego, Sandra Romero-Steiner, Gowrisankar Rajam, Nina E Glass, Cynthia G Whitney,…
Source: The Journal of infectious diseases. 2010 Feb 15
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Optimization and validation of a multiplex, electrochemiluminescence-based detection assay for the quantitation of immunoglobulin G serotype-specific antipneumococcal antibodies in human serum.
Pneumovax 23 consists of a mixture of highly purified capsular polysaccharides (Ps) from 23 of the most prevalent serotypes of Streptococcus pneumonia…
Authors: Rocio D Marchese, Derek Puchalski, Pamela Miller, Joseph Antonello, Olivia Hammond, Tina Green, Leonard J Rubinstein, Michael J Caulfield, Daniel Sikkema
Source: Clinical and vaccine immunology : CVI. 2009 Mar
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Varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccine.
BACKGROUND: The objectives of this study were to evaluate the association between varicella-zoster virus (VZV)-specific humoral and cell-mediated immu…
Authors: Adriana Weinberg, Jane H Zhang, Michael N Oxman, Gary R Johnson, Anthony R Hayward, Michael J Caulfield, Michael R Irwin, James Clair, Jeffrey G Smith, Harold Stanley,…
Source: The Journal of infectious diseases. 2009 Oct 1
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Enzyme-linked immunosorbent assay for measuring antibodies to pneumococcal polysaccharides for the PNEUMOVAX 23 vaccine: assay operating characteristics and correlation to the WHO international assay.
The Merck pneumococcal (Pn) enzyme-linked immunosorbent assays (ELISAs) for measuring antibodies to 12 serotypes (serotypes 1, 3, 4, 6B, 7F, 8, 9V, 12…
Authors: Rocio D Marchese, Neil T Jain, Joseph Antonello, Laura Mallette, Kristin L Butterfield-Gerson, Jennifer Raab, Pamela Burke, Cheryl Schulman, Hilary Adgate, Daniel J Sikkema,…
Source: Clinical and vaccine immunology : CVI. 2006 Aug
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