1 to 10 of 39 literature results

• Principal components analysis corrects for stratification in genome-wide association studies.

  Population stratification--allele frequency differences between cases and controls due to systematic ancestry differences-can cause spurious associati…

  Authors: Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich

  Source: Nature genetics. 2006 Aug

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• REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.

  We conducted a genome-wide association study of rheumatoid arthritis in 2,418 cases and 4,504 controls from North America and identified an associatio…

  Authors: Peter K Gregersen, Chistopher I Amos, Annette T Lee, Yue Lu, Elaine F Remmers, Daniel L Kastner, Michael F Seldin, Lindsey A Criswell, Robert M Plenge, V Michael Holers,…

  Source: Nature genetics. 2009 Jul

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• Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

  Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association …

  Authors: Robert R Graham, Chris Cotsapas, Leela Davies, Rachel Hackett, Christopher J Lessard, Joanlise M Leon, Noel P Burtt, Candace Guiducci, Melissa Parkin, Casey Gates,…

  Source: Nature genetics. 2008 Sep

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• De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot.

  Tetralogy of Fallot (TOF), the most common severe congenital heart malformation, occurs sporadically, without other anomaly, and from unknown cause in…

  Authors: Steven C Greenway, Alexandre C Pereira, Jennifer C Lin, Steven R DePalma, Samuel J Israel, Sonia M Mesquita, Emel Ergul, Jessie H Conta, Joshua M Korn, Steven A McCarroll,…

  Source: Nature genetics. 2009 Aug

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• Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

  Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association …

  Authors: Robert R Graham, Chris Cotsapas, Leela Davies, Rachel Hackett, Christopher J Lessard, Joanlise M Leon, Noel P Burtt, Candace Guiducci, Melissa Parkin, Casey Gates,…

  Source: Nature genetics. 2008 Aug 1

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• Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia.

  Whole-genome association studies are predicted to be especially powerful in isolated populations owing to increased linkage disequilibrium (LD) and de…

  Authors: Penelope E Bonnen, Itsik Pe'er, Robert M Plenge, Jackie Salit, Jennifer K Lowe, Michael H Shapero, Richard P Lifton, Jan L Breslow, Mark J Daly, David E Reich,…

  Source: Nature genetics. 2006 Feb

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• Recent progress in rheumatoid arthritis genetics: one step towards improved patient care.

  PURPOSE OF REVIEW: Recent human genetic discoveries have increased our understanding of rheumatoid arthritis (RA) susceptibility. These discoveries ar…

  Authors: Robert M Plenge

  Source: Current opinion in rheumatology. 2009 May

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• A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.

  Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by activation of the type I interferon (IFN) pathway. Here we convinc…

  Authors: Robert R Graham, Sergey V Kozyrev, Emily C Baechler, M V Prasad Linga Reddy, Robert M Plenge, Jason W Bauer, Ward A Ortmann, Thearith Koeuth, Ma Francisca González Escribano, Argentine and Spanish Collaborative Groups,…

  Source: Nature genetics. 2006 May

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• Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.

  To discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs from 179 independent loci with P < 0.001 in a published meta-…

  Authors: Soumya Raychaudhuri, Brian P Thomson, Elaine F Remmers, Stephen Eyre, Anne Hinks, Candace Guiducci, Joseph J Catanese, Gang Xie, Eli A Stahl, Robert Chen,…

  Source: Nature genetics. 2009 Nov 8

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• Common variants at CD40 and other loci confer risk of rheumatoid arthritis.

  To identify rheumatoid arthritis risk loci in European populations, we conducted a meta-analysis of two published genome-wide association (GWA) studie…

  Authors: Soumya Raychaudhuri, Elaine F Remmers, Annette T Lee, Rachel Hackett, Candace Guiducci, Noël P Burtt, Lauren Gianniny, Benjamin D Korman, Leonid Padyukov, Fina A S Kurreeman,…

  Source: Nature genetics. 2008 Oct

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