1 to 10 of 18 literature results

• Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin.

  Calpains are non-lysosomal calcium-dependent cysteine proteinases that selectively cleave proteins in response to calcium signals and thereby control …

  Authors: Rachel A Hanna, Robert L Campbell, Peter L Davies

  Source: Nature. 2008 Nov 20

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• Genetic model of selective COX2 inhibition reveals novel heterodimer signaling.

  Selective inhibitors of cyclooxygenase-2 (COX2) have attracted widespread media attention because of evidence of an elevated risk of cardiovascular co…

  Authors: Ying Yu, Jinjin Fan, Xin-Sheng Chen, Dairong Wang, Andres J Klein-Szanto, Robert L Campbell, Garret A FitzGerald, Colin D Funk

  Source: Nature medicine. 2006 Jun

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• Cocrystal structures of primed side-extending alpha-ketoamide inhibitors reveal novel calpain-inhibitor aromatic interactions.

  Calpains are intracellular cysteine proteases that catalyze the cleavage of target proteins in response to Ca(2+) signaling. When Ca(2+) homeostasis i…

  Authors: Jin Qian, Dominic Cuerrier, Peter L Davies, Zhaozhao Li, James C Powers, Robert L Campbell

  Source: Journal of medicinal chemistry. 2008 Sep 11

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• Hyperactive antifreeze protein from fish contains multiple ice-binding sites.

  Antifreeze proteins (AFPs) are produced to prevent freezing in many fish species that are exposed to icy seawater. There are a number of nonhomologous…

  Authors: Laurie A Graham, Christopher B Marshall, Feng-Hsu Lin, Robert L Campbell, Peter L Davies

  Source: Biochemistry. 2008 Feb 19

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• Structural modeling of snow flea antifreeze protein.

  The glycine-rich antifreeze protein recently discovered in snow fleas exhibits strong freezing point depression activity without significantly changin…

  Authors: Feng-Hsu Lin, Laurie A Graham, Robert L Campbell, Peter L Davies

  Source: Biophysical journal. 2007 Mar 1

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• Interhemispheric transcallosal subchoroidal fornix-sparing craniotomy for total resection of colloid cysts of the third ventricle.

  OBJECT: Endoscopic surgery has been reported to be more cost-effective and safer than open craniotomy for resection of colloid cysts, despite a 5-10% …

  Authors: Scott Shapiro, Richard Rodgers, Mitesh Shah, Daniel Fulkerson, Robert L Campbell

  Source: Journal of neurosurgery. 2009 Jan

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• Limb-girdle muscular dystrophy type 2A can result from accelerated autoproteolytic inactivation of calpain 3.

  Loss-of-function mutations in calpain 3 have been shown to cause limb-girdle muscular dystrophy type 2A (LGMD2A), an autosomal recessive disorder that…

  Authors: Christopher P Garnham, Rachel A Hanna, Jordan S Chou, Kristin E Low, Keith Gourlay, Robert L Campbell, Jacques S Beckmann, Peter L Davies

  Source: Biochemistry. 2009 Apr 21

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• Molecular modeling of the human multidrug resistance protein 1 (MRP1/ABCC1).

  Multidrug resistance protein 1 (MRP1/ABCC1) is a 190kDa member of the ATP-binding cassette (ABC) superfamily of transmembrane transporters that is cli…

  Authors: Marianne K DeGorter, Gwenaëlle Conseil, Roger G Deeley, Robert L Campbell, Susan P C Cole

  Source: Biochemical and biophysical research communications. 2008 Jan 4

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• Profiling of calpain activity with a series of FRET-based substrates.

  Calpains are intracellular proteases that selectively cleave proteins in response to calcium signals. Although calpains cut many different sequences, …

  Authors: Jacqueline C Kelly, Dominic Cuerrier, Laurie A Graham, Robert L Campbell, Peter L Davies

  Source: Biochimica et biophysica acta. 2009 Oct

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• Distinguishing between calpain heterodimerization and homodimerization.

  The two main mammalian calpains, 1 and 2, are heterodimers of a large 80 kDa and a small 28 kDa subunit that together bind multiple calcium ions durin…

  Authors: Ravikiran Ravulapalli, Robert L Campbell, Sherry Y Gauthier, Sirano Dhe-Paganon, Peter L Davies

  Source: The FEBS journal. 2009 Feb

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