1 to 3 of 3 literature results

• A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia.

  We report the first identified mutation in the gene encoding human cytochrome c (CYCS). Glycine 41, invariant throughout eukaryotes, is substituted by…

  Authors: Ian M Morison, Elisabeth M Cramer Bordé, Emma J Cheesman, Pak Leng Cheong, Andrew J Holyoake, Serge Fichelson, Robert J Weeks, Alexandra Lo, Stefan M K Davies, Sigurd M Wilbanks,…

  Source: Nature genetics. 2008 Apr

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• Detailed methylation analysis of CpG islands on human chromosome region 9p21.

  Deletion of 9p21 is the most commonly reported chromosomal abnormality in pediatric acute lymphoblastic leukemia, and published data suggest that the …

  Authors: Robert J Weeks, Ian M Morison

  Source: Genes, chromosomes & cancer. 2006 Apr

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• Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia.

  Invasive lobular carcinoma (ILC) of the breast is believed to develop from in situ lesions, atypical lobular hyperplasia (ALH), and lobular carcinoma …

  Authors: Donghui Zou, Han-Seung Yoon, David Perez, Robert J Weeks, Parry Guilford, Bostjan Humar

  Source: The Journal of pathology. 2009 Jun

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