1 to 10 of 27 literature results

• Protein tyrosine phosphatases in autoimmunity.

  Protein tyrosine phosphatases (PTPs) are important regulators of many cellular functions and a growing number of PTPs have been implicated in human di…

  Authors: Torkel Vang, Ana V Miletic, Yutaka Arimura, Lutz Tautz, Robert C Rickert, Tomas Mustelin

  Source: Annual review of immunology. 2008

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• CD98hc facilitates B cell proliferation and adaptive humoral immunity.

  The proliferation of antigen-specific lymphocytes and resulting clonal expansion are essential for adaptive immunity. We report here that B cell-speci…

  Authors: Joseph Cantor, Cecille D Browne, Raphael Ruppert, Chloé C Féral, Reinhard Fässler, Robert C Rickert, Mark H Ginsberg

  Source: Nature immunology. 2009 Apr

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• Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy.

  Anergy is a critical physiologic mechanism to sensor self-reactive B cells. However, a biochemical understanding of how anergy is achieved and maintai…

  Authors: Cecille D Browne, Christopher J Del Nagro, Matthew H Cato, Hart S Dengler, Robert C Rickert

  Source: Immunity. 2009 Nov 20

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• Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation.

  The transcription factors Foxo1, Foxo3 and Foxo4 modulate cell fate 'decisions' in diverse systems. Here we show that Foxo1-dependent gene expression …

  Authors: Hart S Dengler, Gisele V Baracho, Sidne A Omori, Shane Bruckner, Karen C Arden, Diego H Castrillon, Ronald A DePinho, Robert C Rickert

  Source: Nature immunology. 2008 Dec

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• Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.

  Complement is an essential innate immune mechanism that recognizes and eradicates microbes and associated toxins. In addition, complement receptors (C…

  Authors: Robert C Rickert

  Source: Current opinion in immunology. 2005 Jun

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• Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function.

  Phosphoinositide 3-kinase (PI3K) and phosphatase and tensin homolog (PTEN) phosphatase serve essential functions in the regulation of cell growth, dif…

  Authors: Amy N Anzelon, Hong Wu, Robert C Rickert

  Source: Nature immunology. 2003 Mar

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• Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling.

  Class-switch recombination (CSR) is essential for humoral immunity. However, the regulation of CSR is not completely understood. Here we demonstrate t…

  Authors: Sidne A Omori, Matthew H Cato, Amy Anzelon-Mills, Kamal D Puri, Miriam Shapiro-Shelef, Kathryn Calame, Robert C Rickert

  Source: Immunity. 2006 Oct

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• Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease.

  Expression of B cell-activating factor (BAFF), a critical B cell survival factor, is elevated in autoimmune and lymphoproliferative disorders. Mice ov…

  Authors: Thomas Enzler, Giuseppina Bonizzi, Gregg J Silverman, Dennis C Otero, George F Widhopf, Amy Anzelon-Mills, Robert C Rickert, Michael Karin

  Source: Immunity. 2006 Sep

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• Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells.

  Stat proteins are latent cytoplasmic transcription factors that are crucial in many aspects of mammalian development. In the immune system, Stat3 has …

  Authors: Jamie L Fornek, Lorraine T Tygrett, Thomas J Waldschmidt, Valeria Poli, Robert C Rickert, Geoffrey S Kansas

  Source: Blood. 2006 Feb 1

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• Act1, a negative regulator in CD40- and BAFF-mediated B cell survival.

  TNF receptor (TNFR) superfamily members, CD40, and BAFFR play critical roles in B cell survival and differentiation. Genetic deficiency in a novel ada…

  Authors: Youcun Qian, Jinzhong Qin, Grace Cui, Mayumi Naramura, E Charles Snow, Carl F Ware, Robert L Fairchild, Sidne A Omori, Robert C Rickert, Martin Scott,…

  Source: Immunity. 2004 Oct

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