1 to 10 of 15 literature results

• Noncompetitive inhibition of hepatocyte growth factor-dependent Met signaling by a phage-derived peptide.

  Dysregulation of hepatocyte growth factor (HGF)-induced signaling via its receptor tyrosine kinase Met results in tumor progression and metastasis. To…

  Authors: Eric M Tam, Steven T Runyon, Lydia Santell, Clifford Quan, Xiaoyi Yao, Daniel Kirchhofer, Nicholas J Skelton, Robert A Lazarus

  Source: Journal of molecular biology. 2009 Jan 9

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• The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus.

  Systemic lupus erythematosus (SLE) is characterised by the production of autoantibodies against ubiquitous antigens, especially nuclear components. Ev…

  Authors: Anthony P Manderson, Francesco Carlucci, Peter J Lachmann, Robert A Lazarus, Richard J Festenstein, H Terence Cook, Mark J Walport, Marina Botto

  Source: Arthritis research & therapy. 2006

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• Inhibitors of Tissue Factor. Factor VIIa for anticoagulant therapy.

  Factor VIIa (FVIIa) is a key serine protease involved in the initiation of the coagulation cascade. It is a glycosylated disulfide-linked heterodimer …

  Authors: Robert A Lazarus, Alan G Olivero, Charles Eigenbrot, Daniel Kirchhofer

  Source: Current medicinal chemistry. 2004 Sep

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• Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B.

  Hepatocyte growth factor activator (HGFA) is a serine protease that converts hepatocyte growth factor (HGF) into its active form. When activated HGF b…

  Authors: Steven Shia, Jennifer Stamos, Daniel Kirchhofer, Bin Fan, Judy Wu, Raquel T Corpuz, Lydia Santell, Robert A Lazarus, Charles Eigenbrot

  Source: Journal of molecular biology. 2005 Mar 11

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• Suppressor of fused regulates Gli activity through a dual binding mechanism.

  The Hedgehog pathway drives proliferation and differentiation by activating the Gli/Ci family of zinc finger transcription factors. Gli/Ci proteins fo…

  Authors: Mark Merchant, Felix F Vajdos, Mark Ultsch, Henry R Maun, Ulrich Wendt, Jennifer Cannon, William Desmarais, Robert A Lazarus, Abraham M de Vos, Frederic J de Sauvage

  Source: Molecular and cellular biology. 2004 Oct

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• Bi-directional SIFT predicts a subset of activating mutations.

  Advancements in sequencing technologies have empowered recent efforts to identify polymorphisms and mutations on a global scale. The large number of v…

  Authors: William Lee, Yan Zhang, Kiran Mukhyala, Robert A Lazarus, Zemin Zhang

  Source: PloS one. 2009

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• The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.

  Hedgehog (Hh) signaling is crucial for many aspects of embryonic development, whereas dysregulation of this pathway is associated with several types o…

  Authors: Ivan Bosanac, Henry R Maun, Suzie J Scales, Xiaohui Wen, Andreas Lingel, J Fernando Bazan, Frederic J de Sauvage, Sarah G Hymowitz, Robert A Lazarus

  Source: Nature structural & molecular biology. 2009 Jul

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• Albumin affinity tags increase peptide half-life in vivo.

  Small organic molecules that bind tightly to serum albumin were applied to the amino terminus of an anticoagulant peptide in an effort to increase its…

  Authors: Michael F T Koehler, Kerry Zobel, Maureen H Beresini, Lisa D Caris, Daniel Combs, Brian D Paasch, Robert A Lazarus

  Source: Bioorganic & medicinal chemistry letters. 2002 Oct 21

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• Engineering exosite peptides for complete inhibition of factor VIIa using a protease switch with substrate phage.

  Limitations of current anticoagulant therapies have led us to develop two distinct classes of exosite peptide inhibitors for the initiator of the clot…

  Authors: Henry R Maun, Charles Eigenbrot, Robert A Lazarus

  Source: The Journal of biological chemistry. 2003 Jun 13

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• Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist.

  Hepatocyte growth factor (HGF), the ligand for the receptor tyrosine kinase Met, is secreted as single chain pro-HGF that lacks signaling activity. Pr…

  Authors: Daniel Kirchhofer, Michael T Lipari, Lydia Santell, Karen L Billeci, Henry R Maun, Wendy N Sandoval, Paul Moran, John Ridgway, Charles Eigenbrot, Robert A Lazarus

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2007 Mar 27

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