1 to 10 of 16 literature results

• Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.

  Imatinib mesylate (Gleevec) is a small-molecule inhibitor of the fusion protein Bcr-Abl, the causal agent in chronic myelogenous leukemia. Here we rep…

  Authors: Risto Kerkelä, Luanda Grazette, Rinat Yacobi, Cezar Iliescu, Richard Patten, Cara Beahm, Brian Walters, Sergei Shevtsov, Stéphanie Pesant, Fred J Clubb,…

  Source: Nature medicine. 2006 Aug

  View Full Text

• Cardiotoxicity of the new cancer therapeutics--mechanisms of, and approaches to, the problem.

  Cardiotoxicity of some targeted therapeutics, including monoclonal antibodies and small-molecule inhibitors, is a reality. Herein we will examine why …

  Authors: Thomas Force, Risto Kerkelä

  Source: Drug discovery today. 2008 Sep

  View Free Full Text

• Functionally opposing roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the regulation of cardiac contractility.

  BACKGROUND: Extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (p38-MAPK) have been shown to regulate various…

  Authors: István Szokodi, Risto Kerkelä, Anna-Maria Kubin, Balázs Sármán, Sampsa Pikkarainen, Attila Kónyi, Iván G Horváth, Lajos Papp, Miklós Tóth, Réka Skoumal,…

  Source: Circulation. 2008 Oct 14

  View Full Text

• Glycogen synthase kinase-3beta -- actively inhibiting hypertrophy.

  A number of signaling pathways are involved in the regulation of cardiac hypertrophy and remodeling. One that serves as an integrator of upstream inpu…

  Authors: Risto Kerkelä, Kathleen Woulfe, Thomas Force

  Source: Trends in cardiovascular medicine. 2007 Apr

  View Full Text

• Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics.

  Authors: Ming Hui Chen, Risto Kerkelä, Thomas Force

  Source: Circulation. 2008 Jul 1

  View Free Full Text

• The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy.

  In cells capable of entering the cell cycle, including cancer cells, beta-catenin has been termed a master switch, driving proliferation over differen…

  Authors: Xin Chen, Sergei P Shevtsov, Eileen Hsich, Lei Cui, Syed Haq, Mark Aronovitz, Risto Kerkelä, Jeffery D Molkentin, Ronglih Liao, Robert N Salomon,…

  Source: Molecular and cellular biology. 2006 Jun

  View Free Full Text

• GATA transcription factors in the developing and adult heart.

  During the past decade, emerging evidence has accumulated of different nuclear transcription factors in regulation of cardiac development and growth a…

  Authors: Sampsa Pikkarainen, Heikki Tokola, Risto Kerkelä, Heikki Ruskoaho

  Source: Cardiovascular research. 2004 Aug 1

  View Full Text

• Identification of PKCalpha isoform-specific effects in cardiac myocytes using antisense phosphorothioate oligonucleotides.

  Members of the mammalian protein kinase C (PKC) superfamily play key regulatory roles in multiple cellular processes. In the heart, PKC signaling is i…

  Authors: Risto Kerkelä, Mika Ilves, Sampsa Pikkarainen, Heikki Tokola, Jarkko Ronkainen, Olli Vuolteenaho, Juhani Leppäluoto, Heikki Ruskoaho

  Source: Molecular pharmacology. 2002 Dec

  View Full Text

• Molecular scaffolds regulate bidirectional crosstalk between Wnt and classical seven-transmembrane-domain receptor signaling pathways.

  Signaling downstream of classical seven-transmembrane domain receptors (7TMRs) had generally been thought to recruit factors that are in large part se…

  Authors: Thomas Force, Kathleen Woulfe, Walter J Koch, Risto Kerkelä

  Source: Science's STKE : signal transduction knowledge environment. 2007 Jul 31

  View Full Text

• Direct cardiac actions of erythropoietin (EPO): effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury.

  EPO (erythropoietin) has recently been shown to have protective actions upon the myocardium; however, the direct effects of EPO upon cardiac contracti…

  Authors: Jarkko Piuhola, Risto Kerkelä, Jacqueline I Keenan, Mark B Hampton, A Mark Richards, Chris J Pemberton

  Source: Clinical science (London, England : 1979). 2008 Feb

  View Full Text