1 to 10 of 77 literature results

• The fibroblast growth factor receptor inhibitor PD173074 blocks small cell lung cancer growth in vitro and in vivo.

  Lung cancer is the commonest cancer killer. Small cell lung cancer (SCLC) is initially chemosensitive, but rapidly relapses in a chemoresistant form w…

  Authors: Olivier E Pardo, John Latigo, Rosemary E Jeffery, Emma Nye, Richard Poulsom, Bradley Spencer-Dene, Nick R Lemoine, Gordon W Stamp, Eric O Aboagye, Michael J Seckl

  Source: Cancer research. 2009 Nov 15

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• The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.

  BACKGROUND & AIMS: We previously demonstrated that the 2 APC mutations in human colorectal tumors are coselected, because tumorigenesis requires an op…

  Authors: Patrick Pollard, Maesha Deheragoda, Stefania Segditsas, Annabelle Lewis, Andrew Rowan, Kimberley Howarth, Lisa Willis, Emma Nye, Amy McCart, Nikki Mandir,…

  Source: Gastroenterology. 2009 Jun

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• Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.

  Germline mutations in the fumarate hydratase (FH) tumor suppressor gene predispose to leiomyomatosis, renal cysts, and renal cell cancer (HLRCC). HLRC…

  Authors: Patrick J Pollard, Bradley Spencer-Dene, Deepa Shukla, Kimberley Howarth, Emma Nye, Mona El-Bahrawy, Maesha Deheragoda, Maria Joannou, Stuart McDonald, Alison Martin,…

  Source: Cancer cell. 2007 Apr

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• CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness.

  CUTL1, also known as CDP, Cut, or Cux-1, is a homeodomain transcriptional regulator known to be involved in development and cell cycle progression. He…

  Authors: Patrick Michl, Antoine R Ramjaun, Olivier E Pardo, Patricia H Warne, Martin Wagner, Richard Poulsom, Corrado D'Arrigo, Kenneth Ryder, Andre Menke, Thomas Gress,…

  Source: Cancer cell. 2005 Jun

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• A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET/GFR alpha 1 receptor up-regulation in breast cancer.

  By screening a tissue microarray of invasive breast tumors, we have shown that the receptor tyrosine kinase RET (REarranged during Transfection) and i…

  Authors: Selma Esseghir, S Katrina Todd, Toby Hunt, Richard Poulsom, Ivan Plaza-Menacho, Jorge S Reis-Filho, Clare M Isacke

  Source: Cancer research. 2007 Dec 15

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• A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts.

  BACKGROUND & AIMS: Bone marrow (BM) cells form differentiated adult lineages within nonhematopoietic tissues, with a heightened propensity with increa…

  Authors: Mairi Brittan, Victoria Chance, George Elia, Richard Poulsom, Malcolm R Alison, Thomas T MacDonald, Nicholas A Wright

  Source: Gastroenterology. 2005 Jun

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• Effects of mouse and human lipocalin homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin on gastrointestinal mucosal integrity and repair.

  BACKGROUND & AIMS: The lipocalin superfamily, including the mouse and human homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin, show …

  Authors: Raymond J Playford, Angelica Belo, Richard Poulsom, Anthony J Fitzgerald, Kevin Harris, Isabella Pawluczyk, Joel Ryon, Thameen Darby, Marit Nilsen-Hamilton, Subrata Ghosh,…

  Source: Gastroenterology. 2006 Sep

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• Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice.

  In order to identify new genes with differential expression in early intestinal tumours, we performed mRNA (messenger ribonucleic acid) expression pro…

  Authors: Stefania Segditsas, Oliver Sieber, Maesha Deheragoda, Phil East, Andrew Rowan, Rosemary Jeffery, Emma Nye, Susan Clark, Bradley Spencer-Dene, Gordon Stamp,…

  Source: Human molecular genetics. 2008 Dec 15

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• Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function.

  The Notch signaling pathway and the delta-like 4 ligand (DLL4) play key roles in embryonic vascular development. Many of the pathways involved in embr…

  Authors: Nilay S Patel, Ji-Liang Li, Daniele Generali, Richard Poulsom, David W Cranston, Adrian L Harris

  Source: Cancer research. 2005 Oct 1

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• Bone marrow-derived stromal cells express lineage-related messenger RNA species.

  Evidence has emerged that bone marrow cells have a greater degree of plasticity than previously thought. However, there has been a call to establish p…

  Authors: Natalie C Direkze, Rosemary Jeffery, Kairbaan Hodivala-Dilke, Toby Hunt, Raymond J Playford, George Elia, Richard Poulsom, Nicholas A Wright, Malcolm R Alison

  Source: Cancer research. 2006 Feb 1

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