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Imatinib mesylate (Gleevec) is a small-molecule inhibitor of the fusion protein Bcr-Abl, the causal agent in chronic myelogenous leukemia. Here we rep…
Authors: Risto Kerkelä, Luanda Grazette, Rinat Yacobi, Cezar Iliescu, Richard Patten, Cara Beahm, Brian Walters, Sergei Shevtsov, Stéphanie Pesant, Fred J Clubb,…
Source: Nature medicine. 2006 Aug
View Full TextGeneration of arachidonic acid by the ubiquitously expressed cytosolic phospholipase A2 (PLA2) has a fundamental role in the regulation of cellular ho…
Authors: Syed Haq, Heiko Kilter, Ashour Michael, Jingzang Tao, Eileen O'Leary, Xio Ming Sun, Brian Walters, Kausik Bhattacharya, Xin Chen, Lei Cui,…
Source: Nature medicine. 2003 Jul
View Full TextBACKGROUND: The contribution of the sarcomere's thin filament to the contractile dysfunction of human cardiomyopathy is not well understood. METHODS A…
Authors: Teruo Noguchi, Mark Hünlich, Phillip C Camp, Kelly J Begin, Mohamed El-Zaru, Richard Patten, Bruce J Leavitt, Frank P Ittleman, Norman R Alpert, Martin M LeWinter,…
Source: Circulation. 2004 Aug 24
View Full TextIn cells capable of entering the cell cycle, including cancer cells, beta-catenin has been termed a master switch, driving proliferation over differen…
Authors: Xin Chen, Sergei P Shevtsov, Eileen Hsich, Lei Cui, Syed Haq, Mark Aronovitz, Risto Kerkelä, Jeffery D Molkentin, Ronglih Liao, Robert N Salomon,…
Source: Molecular and cellular biology. 2006 Jun
View Free Full TextBACKGROUND: Heart failure (HF) remains a major cause of morbidity and mortality in North America. With an aging population and an unmet clinical need …
Authors: Roger J Hajjar, Krisztina Zsebo, Lawrence Deckelbaum, Craig Thompson, Jeff Rudy, Alex Yaroshinsky, Hung Ly, Yoshiaki Kawase, Kim Wagner, Kenneth Borow,…
Source: Journal of cardiac failure. 2008 Jun
View Full TextSignaling through cAMP plays an important role in heart failure. Phosphorylation of cAMP response element binding protein (CREB) at serine-133 regulat…
Authors: Gordon S Huggins, John J Lepore, Sarah Greytak, Richard Patten, Rachel McNamee, Mark Aronovitz, Paul J Wang, Guy L Reed
Source: American journal of physiology. Heart and circulatory physiology. 2007 Sep
View Full TextGlycogen synthase kinase (GSK) 3beta is a negative regulator of stress-induced cardiomyocyte hypertrophy. It is not clear, however, if GSK-3beta plays…
Authors: Ashour Michael, Syed Haq, Xin Chen, Eileen Hsich, Lei Cui, Brian Walters, Zhili Shao, Kausik Bhattacharya, Heiko Kilter, Gordon Huggins,…
Source: The Journal of biological chemistry. 2004 May 14
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