1 to 7 of 7 literature results

• Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.

  Imatinib mesylate (Gleevec) is a small-molecule inhibitor of the fusion protein Bcr-Abl, the causal agent in chronic myelogenous leukemia. Here we rep…

  Authors: Risto Kerkelä, Luanda Grazette, Rinat Yacobi, Cezar Iliescu, Richard Patten, Cara Beahm, Brian Walters, Sergei Shevtsov, Stéphanie Pesant, Fred J Clubb,…

  Source: Nature medicine. 2006 Aug

  View Full Text

• Deletion of cytosolic phospholipase A2 promotes striated muscle growth.

  Generation of arachidonic acid by the ubiquitously expressed cytosolic phospholipase A2 (PLA2) has a fundamental role in the regulation of cellular ho…

  Authors: Syed Haq, Heiko Kilter, Ashour Michael, Jingzang Tao, Eileen O'Leary, Xio Ming Sun, Brian Walters, Kausik Bhattacharya, Xin Chen, Lei Cui,…

  Source: Nature medicine. 2003 Jul

  View Full Text

• Thin-filament-based modulation of contractile performance in human heart failure.

  BACKGROUND: The contribution of the sarcomere's thin filament to the contractile dysfunction of human cardiomyopathy is not well understood. METHODS A…

  Authors: Teruo Noguchi, Mark Hünlich, Phillip C Camp, Kelly J Begin, Mohamed El-Zaru, Richard Patten, Bruce J Leavitt, Frank P Ittleman, Norman R Alpert, Martin M LeWinter,…

  Source: Circulation. 2004 Aug 24

  View Full Text

• The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy.

  In cells capable of entering the cell cycle, including cancer cells, beta-catenin has been termed a master switch, driving proliferation over differen…

  Authors: Xin Chen, Sergei P Shevtsov, Eileen Hsich, Lei Cui, Syed Haq, Mark Aronovitz, Risto Kerkelä, Jeffery D Molkentin, Ronglih Liao, Robert N Salomon,…

  Source: Molecular and cellular biology. 2006 Jun

  View Free Full Text

• Design of a phase 1/2 trial of intracoronary administration of AAV1/SERCA2a in patients with heart failure.

  BACKGROUND: Heart failure (HF) remains a major cause of morbidity and mortality in North America. With an aging population and an unmet clinical need …

  Authors: Roger J Hajjar, Krisztina Zsebo, Lawrence Deckelbaum, Craig Thompson, Jeff Rudy, Alex Yaroshinsky, Hung Ly, Yoshiaki Kawase, Kim Wagner, Kenneth Borow,…

  Source: Journal of cardiac failure. 2008 Jun

  View Full Text

• The CREB leucine zipper regulates CREB phosphorylation, cardiomyopathy, and lethality in a transgenic model of heart failure.

  Signaling through cAMP plays an important role in heart failure. Phosphorylation of cAMP response element binding protein (CREB) at serine-133 regulat…

  Authors: Gordon S Huggins, John J Lepore, Sarah Greytak, Richard Patten, Rachel McNamee, Mark Aronovitz, Paul J Wang, Guy L Reed

  Source: American journal of physiology. Heart and circulatory physiology. 2007 Sep

  View Full Text

• Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart.

  Glycogen synthase kinase (GSK) 3beta is a negative regulator of stress-induced cardiomyocyte hypertrophy. It is not clear, however, if GSK-3beta plays…

  Authors: Ashour Michael, Syed Haq, Xin Chen, Eileen Hsich, Lei Cui, Brian Walters, Zhili Shao, Kausik Bhattacharya, Heiko Kilter, Gordon Huggins,…

  Source: The Journal of biological chemistry. 2004 May 14

  View Full Text