1 to 10 of 19 literature results

• Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice.

  The Aurora-A kinase gene is amplified in a subset of human tumors and in radiation-induced lymphomas from p53 heterozygous mice. Normal tissues from p…

  Authors: Jian-Hua Mao, Di Wu, Jesus Perez-Losada, Tao Jiang, Qian Li, Richard M Neve, Joe W Gray, Wei-Wen Cai, Allan Balmain

  Source: Cancer cell. 2007 Feb

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• A conditional feedback loop regulates Ras activity through EphA2.

  The EphA2 receptor tyrosine kinase is frequently overexpressed in many cancers, including 40% of breast cancers. Here, we show that EphA2 is a direct …

  Authors: Madhu Macrae, Richard M Neve, Pablo Rodriguez-Viciana, Christopher Haqq, Jennifer Yeh, Chira Chen, Joe W Gray, Frank McCormick

  Source: Cancer cell. 2005 Aug

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• A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.

  Recent studies suggest that thousands of genes may contribute to breast cancer pathophysiologies when deregulated by genomic or epigenomic events. Her…

  Authors: Richard M Neve, Koei Chin, Jane Fridlyand, Jennifer Yeh, Frederick L Baehner, Tea Fevr, Laura Clark, Nora Bayani, Jean-Philippe Coppe, Frances Tong,…

  Source: Cancer cell. 2006 Dec

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• Genomic and transcriptional aberrations linked to breast cancer pathophysiologies.

  This study explores the roles of genome copy number abnormalities (CNAs) in breast cancer pathophysiology by identifying associations between recurren…

  Authors: Koei Chin, Sandy DeVries, Jane Fridlyand, Paul T Spellman, Ritu Roydasgupta, Wen-Lin Kuo, Anna Lapuk, Richard M Neve, Zuwei Qian, Tom Ryder,…

  Source: Cancer cell. 2006 Dec

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• Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition.

  Specific inhibitors of mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK) have been developed that efficiently …

  Authors: Olga K Mirzoeva, Debopriya Das, Laura M Heiser, Sanchita Bhattacharya, Doris Siwak, Rina Gendelman, Nora Bayani, Nicholas J Wang, Richard M Neve, Yinghui Guan,…

  Source: Cancer research. 2009 Jan 15

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• An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.

  Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy-based sequencing and reverse-phase pr…

  Authors: Katherine Stemke-Hale, Ana Maria Gonzalez-Angulo, Ana Lluch, Richard M Neve, Wen-Lin Kuo, Michael Davies, Mark Carey, Zhi Hu, Yinghui Guan, Aysegul Sahin,…

  Source: Cancer research. 2008 Aug 1

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• Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells.

  Addition of the ErbB-ligand, Heregulinbeta1 (HRG), to breast tumour-derived T47D cells promotes D-cyclin expression, p21(cip1) synthesis, cyclin-depen…

  Authors: Richard M Neve, Thomas Holbro, Nancy E Hynes

  Source: Oncogene. 2002 Jul 4

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• ErbB2 activation of ESX gene expression.

  Various members of the Ets multigene family exhibit diverse roles in development, cell differentiation, tissue-specific gene expression and human mali…

  Authors: Richard M Neve, Bauke Ylstra, Chuan-Hsiung Chang, Donna G Albertson, Christopher C Benz

  Source: Oncogene. 2002 May 30

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• Identification of an epithelial-specific enhancer regulating ESX expression.

  The Ets transcription factor, ESX, exhibits a unique pattern of epithelial-restricted expression and transactivates genes involved in epithelial diffe…

  Authors: Richard M Neve, Hema Parmar, Cliff Amend, Chira Chen, Angie Rizzino, Christopher C Benz

  Source: Gene. 2006 Feb 15

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• Transcriptional regulation of the murine Elf3 gene in embryonal carcinoma cells and their differentiated counterparts: requirement for a novel upstream regulatory region.

  The transcription factor Elf3, which is one of over 25 Ets family members, is expressed in a wide variety of carcinomas and has been shown to promote …

  Authors: Jingwen Hou, Phillip J Wilder, Cory T Bernadt, Brian Boer, Richard M Neve, Angie Rizzino

  Source: Gene. 2004 Sep 29

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