1 to 10 of 348 literature results

• Regulatory T cells that become autoaggressive.

  Foxp3 expression is not stable and may be extinguished both in vitro and in vivo in regulatory T cells that convert into proinflammatory effector T ce…

  Authors: Daniel Hawiger, Richard A Flavell

  Source: Nature immunology. 2009 Sep

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• TGF-beta: a master of all T cell trades.

  A functional adaptive immune system depends on a diverse and self-tolerant population of T lymphocytes that are generated in the thymus and maintained…

  Authors: Ming O Li, Richard A Flavell

  Source: Cell. 2008 Aug 8

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• Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression.

  The naturally occurring regulatory T cell (T(r)) is the pivotal cell type that maintains self-tolerance and exerts active immune suppression. The deve…

  Authors: Yisong Y Wan, Richard A Flavell

  Source: Nature. 2007 Feb 15

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• Transforming growth factor-beta regulation of immune responses.

  Transforming growth factor-beta (TGF-beta) is a potent regulatory cytokine with diverse effects on hemopoietic cells. The pivotal function of TGF-beta…

  Authors: Ming O Li, Yisong Y Wan, Shomyseh Sanjabi, Anna-Karin L Robertson, Richard A Flavell

  Source: Annual review of immunology. 2006

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• Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels.

  The survival of T lymphocytes requires sustained, Ca(2+) influx-dependent gene expression. The molecular mechanism that governs sustained Ca(2+) influ…

  Authors: Mithilesh K Jha, Abdallah Badou, Marcel Meissner, John E McRory, Marc Freichel, Veit Flockerzi, Richard A Flavell

  Source: Nature immunology. 2009 Dec

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• Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants.

  Aluminium adjuvants, typically referred to as 'alum', are the most commonly used adjuvants in human and animal vaccines worldwide, yet the mechanism u…

  Authors: Stephanie C Eisenbarth, Oscar R Colegio, William O'Connor, Fayyaz S Sutterwala, Richard A Flavell

  Source: Nature. 2008 Jun 19

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• Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.

  Alzheimer's disease is the most common dementia and is pathologically characterized by deposition of amyloid-beta peptide (Abeta) into beta-amyloid pl…

  Authors: Terrence Town, Yasmina Laouar, Christopher Pittenger, Takashi Mori, Christine A Szekely, Jun Tan, Ronald S Duman, Richard A Flavell

  Source: Nature medicine. 2008 Jun

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• The inflammasome: first line of the immune response to cell stress.

  The NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the processing and secretion of proinflammatory cytokines.…

  Authors: Yasunori Ogura, Fayyaz S Sutterwala, Richard A Flavell

  Source: Cell. 2006 Aug 25

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• Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells.

  An effective immune response against infectious agents involves massive expansion of CD8(+) T cells. Once the infection is cleared, the majority of th…

  Authors: Shomyseh Sanjabi, Munir M Mosaheb, Richard A Flavell

  Source: Immunity. 2009 Jul 17

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• Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation.

  Interleukin 17 (IL-17)-producing CD4(+) helper T cells (T(H)-17 cells) share a developmental relationship with Foxp3(+) regulatory T cells (T(reg) cel…

  Authors: Benjamin R Marks, Heba N Nowyhed, Jin-Young Choi, Amanda C Poholek, Jared M Odegard, Richard A Flavell, Joe Craft

  Source: Nature immunology. 2009 Oct

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