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Foxp3 expression is not stable and may be extinguished both in vitro and in vivo in regulatory T cells that convert into proinflammatory effector T ce…
Authors: Daniel Hawiger, Richard A Flavell
Source: Nature immunology. 2009 Sep
View Full TextA functional adaptive immune system depends on a diverse and self-tolerant population of T lymphocytes that are generated in the thymus and maintained…
Authors: Ming O Li, Richard A Flavell
Source: Cell. 2008 Aug 8
View Full TextThe naturally occurring regulatory T cell (T(r)) is the pivotal cell type that maintains self-tolerance and exerts active immune suppression. The deve…
Authors: Yisong Y Wan, Richard A Flavell
Source: Nature. 2007 Feb 15
View Full TextTransforming growth factor-beta (TGF-beta) is a potent regulatory cytokine with diverse effects on hemopoietic cells. The pivotal function of TGF-beta…
Authors: Ming O Li, Yisong Y Wan, Shomyseh Sanjabi, Anna-Karin L Robertson, Richard A Flavell
Source: Annual review of immunology. 2006
View Full TextThe survival of T lymphocytes requires sustained, Ca(2+) influx-dependent gene expression. The molecular mechanism that governs sustained Ca(2+) influ…
Authors: Mithilesh K Jha, Abdallah Badou, Marcel Meissner, John E McRory, Marc Freichel, Veit Flockerzi, Richard A Flavell
Source: Nature immunology. 2009 Dec
View Full TextAluminium adjuvants, typically referred to as 'alum', are the most commonly used adjuvants in human and animal vaccines worldwide, yet the mechanism u…
Authors: Stephanie C Eisenbarth, Oscar R Colegio, William O'Connor, Fayyaz S Sutterwala, Richard A Flavell
Source: Nature. 2008 Jun 19
View Full TextAlzheimer's disease is the most common dementia and is pathologically characterized by deposition of amyloid-beta peptide (Abeta) into beta-amyloid pl…
Authors: Terrence Town, Yasmina Laouar, Christopher Pittenger, Takashi Mori, Christine A Szekely, Jun Tan, Ronald S Duman, Richard A Flavell
Source: Nature medicine. 2008 Jun
View Free Full TextThe NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the processing and secretion of proinflammatory cytokines.…
Authors: Yasunori Ogura, Fayyaz S Sutterwala, Richard A Flavell
Source: Cell. 2006 Aug 25
View Full TextAn effective immune response against infectious agents involves massive expansion of CD8(+) T cells. Once the infection is cleared, the majority of th…
Authors: Shomyseh Sanjabi, Munir M Mosaheb, Richard A Flavell
Source: Immunity. 2009 Jul 17
View Full TextInterleukin 17 (IL-17)-producing CD4(+) helper T cells (T(H)-17 cells) share a developmental relationship with Foxp3(+) regulatory T cells (T(reg) cel…
Authors: Benjamin R Marks, Heba N Nowyhed, Jin-Young Choi, Amanda C Poholek, Jared M Odegard, Richard A Flavell, Joe Craft
Source: Nature immunology. 2009 Oct
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