1 to 10 of 21 literature results

• Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.

  Genome-wide association studies have shown that variation in MTNR1B (melatonin receptor 1B) is associated with insulin and glucose concentrations. Her…

  Authors: Valeriya Lyssenko, Cecilia L F Nagorny, Michael R Erdos, Nils Wierup, Anna Jonsson, Peter Spégel, Marco Bugliani, Richa Saxena, Malin Fex, Nicolo Pulizzi,…

  Source: Nature genetics. 2009 Jan

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• A common variant of HMGA2 is associated with adult and childhood height in the general population.

  Human height is a classic, highly heritable quantitative trait. To begin to identify genetic variants influencing height, we examined genome-wide asso…

  Authors: Michael N Weedon, Guillaume Lettre, Rachel M Freathy, Cecilia M Lindgren, Benjamin F Voight, John R B Perry, Katherine S Elliott, Rachel Hackett, Candace Guiducci, Beverley Shields,…

  Source: Nature genetics. 2007 Oct

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• Variants in MTNR1B influence fasting glucose levels.

  To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-…

  Authors: Inga Prokopenko, Claudia Langenberg, Jose C Florez, Richa Saxena, Nicole Soranzo, Gudmar Thorleifsson, Ruth J F Loos, Alisa K Manning, Anne U Jackson, Yurii Aulchenko,…

  Source: Nature genetics. 2009 Jan

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• Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.

  Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a m…

  Authors: Richa Saxena, Marie-France Hivert, Claudia Langenberg, Toshiko Tanaka, James S Pankow, Peter Vollenweider, Valeriya Lyssenko, Nabila Bouatia-Naji, Josée Dupuis, Anne U Jackson,…

  Source: Nature genetics. 2010 Feb

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• Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

  Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabet…

  Authors: Eleftheria Zeggini, Laura J Scott, Richa Saxena, Benjamin F Voight, Jonathan L Marchini, Tianle Hu, Paul I W de Bakker, Gonçalo R Abecasis, Peter Almgren, Gitte Andersen,…

  Source: Nature genetics. 2008 May

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• New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

  Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide as…

  Authors: Josée Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, Anne U Jackson, Eleanor Wheeler, Nicole L Glazer, Nabila Bouatia-Naji, Anna L Gloyn,…

  Source: Nature genetics. 2010 Feb

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• Comprehensive association testing of common mitochondrial DNA variation in metabolic disease.

  Many lines of evidence implicate mitochondria in phenotypic variation: (a) rare mutations in mitochondrial proteins cause metabolic, neurological, and…

  Authors: Richa Saxena, Paul I W de Bakker, Karyn Singer, Vamsi Mootha, Noel Burtt, Joel N Hirschhorn, Daniel Gaudet, Bo Isomaa, Mark J Daly, Leif Groop,…

  Source: American journal of human genetics. 2006 Jul

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• Tissue-specific alternative splicing of TCF7L2.

  Common variants in the transcription factor 7-like 2 (TCF7L2) gene have been identified as the strongest genetic risk factors for type 2 diabetes (T2D…

  Authors: Ludmila Prokunina-Olsson, Cullan Welch, Ola Hansson, Neeta Adhikari, Laura J Scott, Nicolle Usher, Maurine Tong, Andrew Sprau, Amy Swift, Lori L Bonnycastle,…

  Source: Human molecular genetics. 2009 Oct 15

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• Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.

  OBJECTIVE: Genome-wide association scans (GWASs) have identified novel diabetes-associated genes. We evaluated how these variants impact diabetes inci…

  Authors: Allan F Moore, Kathleen A Jablonski, Jarred B McAteer, Richa Saxena, Toni I Pollin, Paul W Franks, Robert L Hanson, Alan R Shuldiner, William C Knowler, David Altshuler,…

  Source: Diabetes. 2008 Sep

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• A second generation human haplotype map of over 3.1 million SNPs.

  We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from f…

  Authors: International HapMap Consortium, Kelly A Frazer, Dennis G Ballinger, David R Cox, David A Hinds, Laura L Stuve, Richard A Gibbs, John W Belmont, Andrew Boudreau, Paul Hardenbol,…

  Source: Nature. 2007 Oct 18

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