1 to 10 of 13 literature results

• Aminopeptidase A is a functional target in angiogenic blood vessels.

  We show that a membrane-associated protease, aminopeptidase A (APA), is upregulated and enzymatically active in blood vessels of human tumors. To gain…

  Authors: Serena Marchiò, Johanna Lahdenranta, Reinier O Schlingemann, Donatella Valdembri, Pieter Wesseling, Marco A Arap, Amin Hajitou, Michael G Ozawa, Martin Trepel, Ricardo J Giordano,…

  Source: Cancer cell. 2004 Feb

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• Steps toward mapping the human vasculature by phage display.

  The molecular diversity of receptors in human blood vessels remains largely unexplored. We developed a selection method in which peptides that home to…

  Authors: Wadih Arap, Mikhail G Kolonin, Martin Trepel, Johanna Lahdenranta, Marina Cardó-Vila, Ricardo J Giordano, Paul J Mintz, Peter U Ardelt, Virginia J Yao, Claudia I Vidal,…

  Source: Nature medicine. 2002 Feb

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• Design and validation of a bifunctional ligand display system for receptor targeting.

  Here we developed a bacteriophage display particle designed to serve as a bifunctional entity that can target tumors while delivering an agent. We eng…

  Authors: Limor Chen, Amado J Zurita, Peter U Ardelt, Ricardo J Giordano, Wadih Arap, Renata Pasqualini

  Source: Chemistry & biology. 2004 Aug

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• Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries.

  A collection of 60 cell lines derived from human tumors (NCI-60) has been widely explored as a tool for anticancer drug discovery. Here, we profiled t…

  Authors: Mikhail G Kolonin, Laura Bover, Jessica Sun, Amado J Zurita, Kim-Anh Do, Johanna Lahdenranta, Marina Cardó-Vila, Ricardo J Giordano, Diana E Jaalouk, Michael G Ozawa,…

  Source: Cancer research. 2006 Jan 1

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• Structural basis for the interaction of a vascular endothelial growth factor mimic peptide motif and its corresponding receptors.

  Vascular endothelial growth factor (VEGF) is central to the survival and development of the vascular and nervous systems. We screened phage display li…

  Authors: Ricardo J Giordano, Cristiane D Anobom, Marina Cardó-Vila, Jorge Kalil, Ana P Valente, Renata Pasqualini, Fabio C L Almeida, Wadih Arap

  Source: Chemistry & biology. 2005 Oct

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• Combinatorial ligand-directed lung targeting.

  Phage display of random peptide libraries is a powerful, unbiased method frequently used to discover ligands for virtually any protein of interest and…

  Authors: Ricardo J Giordano, Julianna K Edwards, Rubin M Tuder, Wadih Arap, Renata Pasqualini

  Source: Proceedings of the American Thoracic Society. 2009 Aug 15

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• From combinatorial peptide selection to drug prototype (II): Targeting the epidermal growth factor receptor pathway.

  The epidermal growth factor receptor (EGFR), a tyrosine kinase, is central to human tumorigenesis. Typically, three classes of drugs inhibit tyrosine …

  Authors: Marina Cardó-Vila, Ricardo J Giordano, Richard L Sidman, Lawrence F Bronk, Zhen Fan, John Mendelsohn, Wadih Arap, Renata Pasqualini

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2010 Feb 26

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• Next-generation phage display: integrating and comparing available molecular tools to enable cost-effective high-throughput analysis.

  BACKGROUND: Combinatorial phage display has been used in the last 20 years in the identification of protein-ligands and protein-protein interactions, …

  Authors: Emmanuel Dias-Neto, Diana N Nunes, Ricardo J Giordano, Jessica Sun, Gregory H Botz, Kuan Yang, João C Setubal, Renata Pasqualini, Wadih Arap

  Source: PloS one. 2009

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• From combinatorial peptide selection to drug prototype (I): Targeting the vascular endothelial growth factor receptor pathway.

  Inhibition of blood vessel formation is a viable therapeutic approach in angiogenesis-dependent diseases. We previously used a combinatorial screening…

  Authors: Ricardo J Giordano, Marina Cardó-Vila, Ahmad Salameh, Cristiane D Anobom, Benjamin D Zeitlin, David H Hawke, Ana P Valente, Fábio C L Almeida, Jacques E Nör, Richard L Sidman,…

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2010 Feb 26

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• Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse.

  Pulmonary gas exchange relies on a rich capillary network, which, together with alveolar epithelial type I and II cells, form alveolar septa, the func…

  Authors: Ricardo J Giordano, Johanna Lahdenranta, Lijie Zhen, Ugonma Chukwueke, Irina Petrache, Robert R Langley, Isaiah J Fidler, Renata Pasqualini, Rubin M Tuder, Wadih Arap

  Source: The Journal of biological chemistry. 2008 Oct 24

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