1 to 10 of 27 literature results

• TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation.

  Dendritic cells (DCs) are professional antigen-presenting cells that have the ability to sense infection and tissue stress, sample and present antigen…

  Authors: Yong-Jun Liu, Vasilli Soumelis, Norihiko Watanabe, Tomoki Ito, Yui-Hsi Wang, Rene de Waal Malefyt, Miyuki Omori, Baohua Zhou, Steven F Ziegler

  Source: Annual review of immunology. 2007

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• Development, cytokine profile and function of human interleukin 17-producing helper T cells.

  T(H)-17 cells are a distinct lineage of proinflammatory T helper cells that are essential for autoimmune disease. In mice, commitment to the T(H)-17 l…

  Authors: Nicholas J Wilson, Katia Boniface, Jason R Chan, Brent S McKenzie, Wendy M Blumenschein, Jeanine D Mattson, Beth Basham, Kathleen Smith, Taiying Chen, Franck Morel,…

  Source: Nature immunology. 2007 Sep

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• Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion.

  T cell homeostasis is a self-regulating process for maintaining the size of the peripheral T cell pool. Although dendritic cells (DCs) seem to be impo…

  Authors: Norihiko Watanabe, Shino Hanabuchi, Vassili Soumelis, Wei Yuan, Stephen Ho, Rene de Waal Malefyt, Yong-Jun Liu

  Source: Nature immunology. 2004 Apr

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• Molecular regulation of Th2 immunity by dendritic cells.

  The interactions between dendritic cells (DCs) and T cells determine the fate of an immune response to pathogenic microbes and to harmless allergens a…

  Authors: Gabriele Grunig, Alice Banz, Rene de Waal Malefyt

  Source: Pharmacology & therapeutics. 2005 Apr

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• Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.

  Whether epithelial cells play a role in triggering the immune cascade leading to T helper 2 (T(H)2)-type allergic inflammation is not known. We show h…

  Authors: Vassili Soumelis, Pedro A Reche, Holger Kanzler, Wei Yuan, Gina Edward, Bernhart Homey, Michel Gilliet, Steve Ho, Svetlana Antonenko, Annti Lauerma,…

  Source: Nature immunology. 2002 Jul

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• The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS).

  Interleukin-10 (IL-10) is an immunoregulatory cytokine that plays a crucial role in inflammatory and immune reactions. It has potent anti-inflammatory…

  Authors: Amy M Beebe, Daniel J Cua, Rene de Waal Malefyt

  Source: Cytokine & growth factor reviews. 2002 Aug-Oct

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• Functional Roles of Thymic Stromal Lymphopoietin for Chronic Allergic Keratoconjunctivitis.

  Purpose: Previous reports have shown the roles of thymic stromal lymphopoietin (TSLP) for atopic diseases. We investigated the expression of TSLP in t…

  Authors: Akira Matsuda, Nobuyuki Ebihara, Norihiko Yokoi, Satoshi Kawasaki, Hidetoshi Tanioka, Tsutomu Inatomi, Rene de Waal Malefyt, Junji Hamuro, Shigeru Kinoshita, Akira Murakami

  Source: Investigative ophthalmology & visual science. 2009 Sep 9

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• IL-12 and IL-23: master regulators of innate and adaptive immunity.

  Initiation of an effective immune response requires close interactions between innate and adaptive immunity. Recent advances in the field of cytokine …

  Authors: Claire L Langrish, Brent S McKenzie, Nicholas J Wilson, Rene de Waal Malefyt, Robert A Kastelein, Daniel J Cua

  Source: Immunological reviews. 2004 Dec

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• IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells.

  An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by …

  Authors: Stefan Pflanz, Jackie C Timans, Jeanne Cheung, Rency Rosales, Holger Kanzler, Jonathan Gilbert, Linda Hibbert, Tatyana Churakova, Marilyn Travis, Elena Vaisberg,…

  Source: Immunity. 2002 Jun

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• A canine model of cutaneous late-phase reactions: prednisolone inhibition of cellular and cytokine responses.

  Immunoglobulin E (IgE)-mediated late-phase reactions can be induced in atopic humans by intradermal injection of relevant allergens or anti-IgE antibo…

  Authors: Cherie M Pucheu-Haston, Dale Shuster, Thierry Olivry, Philippe Brianceau, Patrick Lockwood, Terrill McClanahan, Rene de Waal Malefyt, Jeanine D Mattson, Bruce Hammerberg

  Source: Immunology. 2006 Feb

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