1 to 10 of 122 literature results

• Integrin-linked kinase is an adaptor with essential functions during mouse development.

  The development of multicellular organisms requires integrin-mediated interactions between cells and their extracellular environment. Integrin binding…

  Authors: Anika Lange, Sara A Wickström, Madis Jakobson, Roy Zent, Kirsi Sainio, Reinhard Fässler

  Source: Nature. 2009 Oct 15

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• Kindlin-3 is essential for integrin activation and platelet aggregation.

  Integrin-mediated platelet adhesion and aggregation are essential for sealing injured blood vessels and preventing blood loss, and excessive platelet …

  Authors: Markus Moser, Bernhard Nieswandt, Siegfried Ussar, Miroslava Pozgajova, Reinhard Fässler

  Source: Nature medicine. 2008 Mar

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• The Kindlin protein family: new members to the club of focal adhesion proteins.

  Kindlins are a group of proteins that have recently attracted attention for their ability to bind and activate integrins. Moreover, they have also bee…

  Authors: Alexander Meves, Christopher Stremmel, Kay Gottschalk, Reinhard Fässler

  Source: Trends in cell biology. 2009 Oct

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• Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.

  The rapid turnover and exfoliation of mucosal epithelial cells provides an innate defence system against bacterial infection. Nevertheless, many patho…

  Authors: Minsoo Kim, Michinaga Ogawa, Yukihiro Fujita, Yuko Yoshikawa, Takeshi Nagai, Tomohiro Koyama, Shinya Nagai, Anika Lange, Reinhard Fässler, Chihiro Sasakawa

  Source: Nature. 2009 May 28

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• CD98hc facilitates B cell proliferation and adaptive humoral immunity.

  The proliferation of antigen-specific lymphocytes and resulting clonal expansion are essential for adaptive immunity. We report here that B cell-speci…

  Authors: Joseph Cantor, Cecille D Browne, Raphael Ruppert, Chloé C Féral, Reinhard Fässler, Robert C Rickert, Mark H Ginsberg

  Source: Nature immunology. 2009 Apr

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• Genetic and cell biological analysis of integrin outside-in signaling.

  Integrins are cell surface transmembrane receptors that recognize and bind to extracellular matrix proteins and counter receptors. Binding of activate…

  Authors: Kyle R Legate, Sara A Wickström, Reinhard Fässler

  Source: Genes & development. 2009 Feb 15

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• Integrins anchor the invasive machinery.

  Cell invasion through the basement membrane, a process important for both development and disease pathogenesis, depends on an interplay of adhesive, f…

  Authors: Sara A Wickström, Reinhard Fässler

  Source: Developmental cell. 2009 Aug

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• Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells.

  Integrin activation is essential for the function of all blood cells, including platelets and leukocytes. The blood cell-specific FERM domain protein …

  Authors: Markus Moser, Martina Bauer, Stephan Schmid, Raphael Ruppert, Sarah Schmidt, Michael Sixt, Hao-Ven Wang, Markus Sperandio, Reinhard Fässler

  Source: Nature medicine. 2009 Mar

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• How ILK and kindlins cooperate to orchestrate integrin signaling.

  Integrin-mediated cell adhesion regulates multiple cellular processes crucial for development, physiology, and pathology. Since integrins lack enzymat…

  Authors: Ralph T Böttcher, Anika Lange, Reinhard Fässler

  Source: Current opinion in cell biology. 2009 Oct

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• Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction.

  Vascular smooth muscle cells (VSMCs) form contractile layers around larger blood vessels in a process that is essential for the formation of a fully f…

  Authors: Naoko Kogata, Rachel M Tribe, Reinhard Fässler, Michael Way, Ralf H Adams

  Source: Genes & development. 2009 Oct 1

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