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The development of multicellular organisms requires integrin-mediated interactions between cells and their extracellular environment. Integrin binding…
Authors: Anika Lange, Sara A Wickström, Madis Jakobson, Roy Zent, Kirsi Sainio, Reinhard Fässler
Source: Nature. 2009 Oct 15
View Full TextIntegrin-mediated platelet adhesion and aggregation are essential for sealing injured blood vessels and preventing blood loss, and excessive platelet …
Authors: Markus Moser, Bernhard Nieswandt, Siegfried Ussar, Miroslava Pozgajova, Reinhard Fässler
Source: Nature medicine. 2008 Mar
View Full TextKindlins are a group of proteins that have recently attracted attention for their ability to bind and activate integrins. Moreover, they have also bee…
Authors: Alexander Meves, Christopher Stremmel, Kay Gottschalk, Reinhard Fässler
Source: Trends in cell biology. 2009 Oct
View Full TextThe rapid turnover and exfoliation of mucosal epithelial cells provides an innate defence system against bacterial infection. Nevertheless, many patho…
Authors: Minsoo Kim, Michinaga Ogawa, Yukihiro Fujita, Yuko Yoshikawa, Takeshi Nagai, Tomohiro Koyama, Shinya Nagai, Anika Lange, Reinhard Fässler, Chihiro Sasakawa
Source: Nature. 2009 May 28
View Full TextThe proliferation of antigen-specific lymphocytes and resulting clonal expansion are essential for adaptive immunity. We report here that B cell-speci…
Authors: Joseph Cantor, Cecille D Browne, Raphael Ruppert, Chloé C Féral, Reinhard Fässler, Robert C Rickert, Mark H Ginsberg
Source: Nature immunology. 2009 Apr
View Free Full TextIntegrins are cell surface transmembrane receptors that recognize and bind to extracellular matrix proteins and counter receptors. Binding of activate…
Authors: Kyle R Legate, Sara A Wickström, Reinhard Fässler
Source: Genes & development. 2009 Feb 15
View Full TextCell invasion through the basement membrane, a process important for both development and disease pathogenesis, depends on an interplay of adhesive, f…
Authors: Sara A Wickström, Reinhard Fässler
Source: Developmental cell. 2009 Aug
View Full TextIntegrin activation is essential for the function of all blood cells, including platelets and leukocytes. The blood cell-specific FERM domain protein …
Authors: Markus Moser, Martina Bauer, Stephan Schmid, Raphael Ruppert, Sarah Schmidt, Michael Sixt, Hao-Ven Wang, Markus Sperandio, Reinhard Fässler
Source: Nature medicine. 2009 Mar
View Full TextIntegrin-mediated cell adhesion regulates multiple cellular processes crucial for development, physiology, and pathology. Since integrins lack enzymat…
Authors: Ralph T Böttcher, Anika Lange, Reinhard Fässler
Source: Current opinion in cell biology. 2009 Oct
View Full TextVascular smooth muscle cells (VSMCs) form contractile layers around larger blood vessels in a process that is essential for the formation of a fully f…
Authors: Naoko Kogata, Rachel M Tribe, Reinhard Fässler, Michael Way, Ralf H Adams
Source: Genes & development. 2009 Oct 1
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