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Lung cancer is the most common cause of cancer death worldwide, with over one million cases annually. To identify genetic factors that modify disease …
Authors: Rayjean J Hung, James D McKay, Valerie Gaborieau, Paolo Boffetta, Mia Hashibe, David Zaridze, Anush Mukeria, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai,…
Source: Nature. 2008 Apr 3
View Full TextAlcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have inv…
Authors: Mia Hashibe, James D McKay, Maria Paula Curado, Jose Carlos Oliveira, Sergio Koifman, Rosalina Koifman, David Zaridze, Oxana Shangina, Victor Wünsch-Filho, Jose Eluf-Neto,…
Source: Nature genetics. 2008 Jun
View Full TextWhether consumption of cruciferous vegetables protects against lung cancer is unclear, largely because of potential confounding factors. We therefore …
Authors: Paul Brennan, Charles C Hsu, Norman Moullan, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, David Zaridze, Peter Rudnai, Eleonora Fabianova, Dana Mates, Vladimir Bencko,…
Source: Lancet. 2005 Oct 29-Nov 4
View Full TextWe carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 contr…
Authors: James D McKay, Rayjean J Hung, Valerie Gaborieau, Paolo Boffetta, Amelie Chabrier, Graham Byrnes, David Zaridze, Anush Mukeria, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska,…
Source: Nature genetics. 2008 Dec
View Free Full TextThe global increase in lung cancer burden, together with its poor survival and resistance to classical chemotherapy, underscores the need for identifi…
Authors: Thomas Vaissière, Rayjean J Hung, David Zaridze, Anush Moukeria, Cyrille Cuenin, Virginie Fasolo, Gilles Ferro, Anupam Paliwal, Pierre Hainaut, Paul Brennan,…
Source: Cancer research. 2009 Jan 1
View Free Full TextMutations in the tyrosine kinase domain of the epidermal growth factor receptor EGFR are common in non-small cell lung cancer (NSCLC) of never smokers…
Authors: Mounia Mounawar, Anush Mukeria, Florence Le Calvez, Rayjean J Hung, Helene Renard, Alexis Cortot, Claire Bollart, David Zaridze, Paul Brennan, Paolo Boffetta,…
Source: Cancer research. 2007 Jun 15
View Full TextWith the advent of rapid and relatively cheap genotyping technologies there is now the opportunity to attempt to identify gene-environment and gene-ge…
Authors: Jon Wakefield, Frank De Vocht, Rayjean J Hung
Source: Genetic epidemiology. 2010 Jan
View Full TextBACKGROUND: Base excision repair (BER) is a highly conserved essential mechanism for maintaining genome integrity. We examined associations among four…
Authors: Rayjean J Hung, Paul Brennan, Federico Canzian, Neonila Szeszenia-Dabrowska, David Zaridze, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Dana Mates, Lenka Foretova,…
Source: Journal of the National Cancer Institute. 2005 Apr 20
View Full TextTP53 mutations are common in lung cancers of smokers, with high prevalence of G:C-to-T:A transversions generally interpreted as mutagen fingerprints o…
Authors: Florence Le Calvez, Anush Mukeria, Jay D Hunt, Olaf Kelm, Rayjean J Hung, Philippe Tanière, Paul Brennan, Paolo Boffetta, David G Zaridze, Pierre Hainaut
Source: Cancer research. 2005 Jun 15
View Full TextNeuroblastoma is the most common tumour in children less than 1 year of age. The goal of this review was to summarise the existing epidemiological res…
Authors: Julia E Heck, Beate Ritz, Rayjean J Hung, Mia Hashibe, Paolo Boffetta
Source: Paediatric and perinatal epidemiology. 2009 Mar
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