1 to 10 of 37 literature results

• A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.

  Lung cancer is the most common cause of cancer death worldwide, with over one million cases annually. To identify genetic factors that modify disease …

  Authors: Rayjean J Hung, James D McKay, Valerie Gaborieau, Paolo Boffetta, Mia Hashibe, David Zaridze, Anush Mukeria, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai,…

  Source: Nature. 2008 Apr 3

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• Multiple ADH genes are associated with upper aerodigestive cancers.

  Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have inv…

  Authors: Mia Hashibe, James D McKay, Maria Paula Curado, Jose Carlos Oliveira, Sergio Koifman, Rosalina Koifman, David Zaridze, Oxana Shangina, Victor Wünsch-Filho, Jose Eluf-Neto,…

  Source: Nature genetics. 2008 Jun

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• Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach.

  Whether consumption of cruciferous vegetables protects against lung cancer is unclear, largely because of potential confounding factors. We therefore …

  Authors: Paul Brennan, Charles C Hsu, Norman Moullan, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, David Zaridze, Peter Rudnai, Eleonora Fabianova, Dana Mates, Vladimir Bencko,…

  Source: Lancet. 2005 Oct 29-Nov 4

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• Lung cancer susceptibility locus at 5p15.33.

  We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 contr…

  Authors: James D McKay, Rayjean J Hung, Valerie Gaborieau, Paolo Boffetta, Amelie Chabrier, Graham Byrnes, David Zaridze, Anush Mukeria, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska,…

  Source: Nature genetics. 2008 Dec

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• Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors.

  The global increase in lung cancer burden, together with its poor survival and resistance to classical chemotherapy, underscores the need for identifi…

  Authors: Thomas Vaissière, Rayjean J Hung, David Zaridze, Anush Moukeria, Cyrille Cuenin, Virginie Fasolo, Gilles Ferro, Anupam Paliwal, Pierre Hainaut, Paul Brennan,…

  Source: Cancer research. 2009 Jan 1

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• Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history.

  Mutations in the tyrosine kinase domain of the epidermal growth factor receptor EGFR are common in non-small cell lung cancer (NSCLC) of never smokers…

  Authors: Mounia Mounawar, Anush Mukeria, Florence Le Calvez, Rayjean J Hung, Helene Renard, Alexis Cortot, Claire Bollart, David Zaridze, Paul Brennan, Paolo Boffetta,…

  Source: Cancer research. 2007 Jun 15

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• Bayesian mixture modeling of gene-environment and gene-gene interactions.

  With the advent of rapid and relatively cheap genotyping technologies there is now the opportunity to attempt to identify gene-environment and gene-ge…

  Authors: Jon Wakefield, Frank De Vocht, Rayjean J Hung

  Source: Genetic epidemiology. 2010 Jan

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• Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter study.

  BACKGROUND: Base excision repair (BER) is a highly conserved essential mechanism for maintaining genome integrity. We examined associations among four…

  Authors: Rayjean J Hung, Paul Brennan, Federico Canzian, Neonila Szeszenia-Dabrowska, David Zaridze, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Dana Mates, Lenka Foretova,…

  Source: Journal of the National Cancer Institute. 2005 Apr 20

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• TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke: distinct patterns in never, former, and current smokers.

  TP53 mutations are common in lung cancers of smokers, with high prevalence of G:C-to-T:A transversions generally interpreted as mutagen fingerprints o…

  Authors: Florence Le Calvez, Anush Mukeria, Jay D Hunt, Olaf Kelm, Rayjean J Hung, Philippe Tanière, Paul Brennan, Paolo Boffetta, David G Zaridze, Pierre Hainaut

  Source: Cancer research. 2005 Jun 15

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• The epidemiology of neuroblastoma: a review.

  Neuroblastoma is the most common tumour in children less than 1 year of age. The goal of this review was to summarise the existing epidemiological res…

  Authors: Julia E Heck, Beate Ritz, Rayjean J Hung, Mia Hashibe, Paolo Boffetta

  Source: Paediatric and perinatal epidemiology. 2009 Mar

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