1 to 10 of 78 literature results

• Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.

  Delta(9)-tetrahydrocannabinol binds cannabinoid (CB(1) and CB(2)) receptors, which are activated by endogenous compounds (endocannabinoids) and are in…

  Authors: Angelo A Izzo, Francesca Borrelli, Raffaele Capasso, Vincenzo Di Marzo, Raphael Mechoulam

  Source: Trends in pharmacological sciences. 2009 Oct

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• Novel natural and synthetic ligands of the endocannabinoid system.

  In this review we describe recent advances in the chemistry of novel CB(1)/CB(2) agonists, CB(1) antagonists, selective CB(2) agonists, fatty acid ami…

  Authors: Lumír O Hanus, Raphael Mechoulam

  Source: Current medicinal chemistry. 2010

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• Cannabis and alcohol--a close friendship.

  Cannabinoids and alcohol activate the same reward pathways, and the cannabinoid CB(1) receptor system plays an important role in regulating the positi…

  Authors: Raphael Mechoulam, Linda Parker

  Source: Trends in pharmacological sciences. 2003 Jun

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• Endocannabinoids in liver disease and hepatic encephalopathy.

  Chronic liver disease results from a variety of causes such as hepatitis virus infections, autoimmune processes and alcohol consumption. Its complicat…

  Authors: Iddo Magen, Yosefa Avraham, Elliot Berry, Raphael Mechoulam

  Source: Current pharmaceutical design. 2008

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• Cannabinoid receptor dependent and independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor positive and negative prostate cancer cell lines.

  The omega-3 fatty acid ethanolamides, docosahexaenoyl ethanolamide (DHEA) and eicosapentaenoyl ethanolamide (EPEA), displayed greater anti-proliferati…

  Authors: Iain Brown, Maria G Cascio, Klaus W J Wahle, Reem Smoum, Raphael Mechoulam, Ruth A Ross, Roger G Pertwee, Steven D Heys

  Source: Carcinogenesis. 2010 Jul 25

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• Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation.

  BACKGROUND/AIMS: The endocannabinoid system in mice plays a role in models of human cirrhosis and hepatic encephalopathy (HE), induced by a hepatotoxi…

  Authors: Iddo Magen, Yosefa Avraham, Zvi Ackerman, Lia Vorobiev, Raphael Mechoulam, Elliot M Berry

  Source: Journal of hepatology. 2009 Sep

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• Plant cannabinoids: a neglected pharmacological treasure trove.

  Most of the cannabinoids in Cannabis sativa L. have not been fully evaluated for their pharmacological activity. A publication in this issue presents …

  Authors: Raphael Mechoulam

  Source: British journal of pharmacology. 2005 Dec

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• Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2.

  Here, we show a novel pharmacology for inhibition of human neutrophil migration by endocannabinoids, phytocannabinoids, and related compounds. The end…

  Authors: Douglas McHugh, Carolyn Tanner, Raphael Mechoulam, Roger G Pertwee, Ruth A Ross

  Source: Molecular pharmacology. 2008 Feb

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• Cannabinoids and brain injury: therapeutic implications.

  Mounting in vitro and in vivo data suggest that the endocannabinoids anandamide and 2-arachidonoyl glycerol, as well as some plant and synthetic canna…

  Authors: Raphael Mechoulam, David Panikashvili, Esther Shohami

  Source: Trends in molecular medicine. 2002 Feb

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• The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells.

  Diabetic neuropathy (DN) is a common complication of diabetes mellitus resulting in cognitive dysfunction and synaptic plasticity impairment. Hypergly…

  Authors: Yossi Dagon, Yosefa Avraham, Gabriela Link, Olga Zolotarev, Raphael Mechoulam, Elliot M Berry

  Source: Neurobiology of disease. 2007 Aug

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