1 to 10 of 52 literature results

• HIF prolyl hydroxylase inhibitors prevent neuronal death induced by mitochondrial toxins: therapeutic implications for Huntington's disease and Alzheimer's disease.

  Mitochondrial dysfunction is a central feature of a number of acute and chronic neurodegenerative conditions, but clinically approved therapeutic inte…

  Authors: Zoya Niatsetskaya, Manuela Basso, Rachel E Speer, Stephen J McConoughey, Giovanni Coppola, Thong C Ma, Rajiv R Ratan

  Source: Antioxidants & redox signaling. 2010 Apr

  View Full Text

• CD81, a cell cycle regulator, is a novel target for histone deacetylase inhibition in glioma cells.

  Recent advances in cancer cell biology have focused on histone deacetylase inhibitors (HDACi's) because they target pathways critical to the developme…

  Authors: JoAnn M Gensert, Oxana V Baranova, David E Weinstein, Rajiv R Ratan

  Source: Neurobiology of disease. 2007 Jun

  View Full Text

• Antioxidants, HIF prolyl hydroxylase inhibitors or short interfering RNAs to BNIP3 or PUMA, can prevent prodeath effects of the transcriptional activator, HIF-1alpha, in a mouse hippocampal neuronal line.

  Hypoxia-inducible factor (HIF) is a transcriptional activator that promotes death or survival in neurons. The regulators and targets of HIF-1alpha-med…

  Authors: Leila R Aminova, Ambreena Siddiq, Rajiv R Ratan

  Source: Antioxidants & redox signaling. 2008 Dec

  View Free Full Text

• Putting the 'HAT' back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions.

  Decreased histone acetyltransferase activity and transcriptional dysfunction have been implicated in almost all neurodegenerative conditions. Increasi…

  Authors: Sama F Sleiman, Manuela Basso, Lata Mahishi, Alan P Kozikowski, Mary E Donohoe, Brett Langley, Rajiv R Ratan

  Source: Expert opinion on investigational drugs. 2009 May

  View Free Full Text

• Mining genome databases for therapeutic gold: SIM2 is a novel target for treatment of solid tumors.

  Authors: Rajiv R Ratan

  Source: Trends in pharmacological sciences. 2003 Oct

  View Full Text

• The metabolic coupling of arginine metabolism to nitric oxide generation by astrocytes.

  Arginine, the only known precursor of nitric oxide, enters the brain parenchyma from the blood through the endothelial cells or from the cerebral spin…

  Authors: Joann M Gensert, Rajiv R Ratan

  Source: Antioxidants & redox signaling. 2006 May-Jun

  View Full Text

• Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro.

  Elevation of cAMP can overcome myelin inhibitors to encourage regeneration of the CNS. We show that a consequence of elevated cAMP is the synthesis of…

  Authors: Dongming Cai, Kangwen Deng, Wilfredo Mellado, Junghee Lee, Rajiv R Ratan, Marie T Filbin

  Source: Neuron. 2002 Aug 15

  View Full Text

• Epigenetics and the nervous system: epiphenomenon or missing piece of the neurotherapeutic puzzle?

  Authors: Rajiv R Ratan

  Source: Lancet neurology. 2009 Nov

  View Full Text

• cAMP response element binding protein family transcription factors: the Holy Grail of neurological therapeutics?

  Authors: Rajiv R Ratan

  Source: Annals of neurology. 2004 Nov

  View Full Text

• A nonradioactive dot blot assay for transglutaminase activity.

  Aberrant transglutaminase (TG) activity has been implicated in the pathology of numerous diseases, including Huntington's disease and Alzheimer's dise…

  Authors: Stephen J McConoughey, Zoya V Niatsetskaya, Ralf Pasternack, Martin Hils, Rajiv R Ratan, Arthur J L Cooper

  Source: Analytical biochemistry. 2009 Jul 1

  View Full Text