1 to 10 of 18 literature results

• Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

  Psoriasis is a common immune-mediated disorder that affects the skin, nails and joints. To identify psoriasis susceptibility loci, we genotyped 438,67…

  Authors: Rajan P Nair, Kristina Callis Duffin, Cynthia Helms, Jun Ding, Philip E Stuart, David Goldgar, Johann E Gudjonsson, Yun Li, Trilokraj Tejasvi, Bing-Jian Feng,…

  Source: Nature genetics. 2009 Feb

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• Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.

  Previous studies have narrowed the interval containing PSORS1, the psoriasis-susceptibility locus in the major histocompatibility complex (MHC), to an…

  Authors: Rajan P Nair, Philip E Stuart, Ioana Nistor, Ravi Hiremagalore, Nicholas V C Chia, Stefan Jenisch, Michael Weichenthal, Gonçalo R Abecasis, Henry W Lim, Enno Christophers,…

  Source: American journal of human genetics. 2006 May

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• Genetic evidence for involvement of the IL23 pathway in Thai psoriatics.

  A recent genome-wide association analysis of psoriasis identified IL12B and IL23R as significantly associated with psoriasis. Here we report associati…

  Authors: Rajan P Nair, Philip E Stuart, Preya Kullavanijaya, Prisana Kullavanijaya, Trilokraj Tejasvi, John J Voorhees, James T Elder

  Source: Archives of dermatological research. 2010 Mar

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• BRAF and NRAS mutations in melanoma and melanocytic nevi.

  In this report, we investigated BRAF/NRAS mutations in samples from a case-control study of melanoma and a series of benign melanocytic nevi. We evalu…

  Authors: Jenny N Poynter, James T Elder, Douglas R Fullen, Rajan P Nair, Maria S Soengas, Timothy M Johnson, Bruce Redman, Nancy E Thomas, Stephen B Gruber

  Source: Melanoma research. 2006 Aug

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• Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus.

  Human leukocyte antigen (HLA) class I and class II alleles are implicated as genetic risk factors for many autoimmune diseases. However, the role of t…

  Authors: Robert R Graham, Ward A Ortmann, Carl D Langefeld, Damini Jawaheer, Scott A Selby, Peter R Rodine, Emily C Baechler, Kristine E Rohlf, Katherine B Shark, Karl J Espe,…

  Source: American journal of human genetics. 2002 Sep

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• Psoriasis bench to bedside: genetics meets immunology.

  Authors: Rajan P Nair, Jun Ding, Kristina Callis Duffin, Cynthia Helms, John J Voorhees, Gerald G Krueger, Anne M Bowcock, Goncalo R Abeçasis, James T Elder

  Source: Archives of dermatology. 2009 Apr

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• Molecular dissection of psoriasis: integrating genetics and biology.

  Psoriasis is a common and debilitating disease of the skin, nails, and joints, with an acknowledged but complex genetic basis. Early genome-wide linka…

  Authors: James T Elder, Allen T Bruce, Johann E Gudjonsson, Andrew Johnston, Philip E Stuart, Trilokraj Tejasvi, John J Voorhees, Gonçalo R Abecasis, Rajan P Nair

  Source: The Journal of investigative dermatology. 2010 May

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• Assessment of the psoriatic transcriptome in a large sample: additional regulated genes and comparisons with in vitro models.

  To further elucidate molecular alterations in psoriasis, we performed a gene expression study of 58 paired lesional and uninvolved psoriatic and 64 co…

  Authors: Johann E Gudjonsson, Jun Ding, Andrew Johnston, Trilokraj Tejasvi, Andrew M Guzman, Rajan P Nair, John J Voorhees, Goncalo R Abecasis, James T Elder

  Source: The Journal of investigative dermatology. 2010 Jul

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• Evidence for altered Wnt signaling in psoriatic skin.

  The Wnt gene family encodes a set of highly conserved secreted signaling proteins that have major roles in embryogenesis and tissue homeostasis. Yet t…

  Authors: Johann E Gudjonsson, Andrew Johnston, Stefan W Stoll, Mary B Riblett, Xianying Xing, James J Kochkodan, Jun Ding, Rajan P Nair, Abhishek Aphale, John J Voorhees,…

  Source: The Journal of investigative dermatology. 2010 Jul

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• Lack of evidence for activation of the hedgehog pathway in psoriasis.

  Recent reports have suggested that the hedgehog (Hh) pathway is activated in lesional psoriatic skin, and that treatment with the Hh pathway antagonis…

  Authors: Johann E Gudjonsson, Abhishek Aphale, Marina Grachtchouk, Jun Ding, Rajan P Nair, Timothy Wang, John J Voorhees, Andrzej A Dlugosz, James T Elder

  Source: The Journal of investigative dermatology. 2009 Mar

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