1 to 10 of 15 literature results

• Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation.

  Defining critical points of modulation across heterogeneous clinical syndromes may provide insight into new therapeutic approaches. Coagulation initia…

  Authors: Frank Niessen, Florence Schaffner, Christian Furlan-Freguia, Rafal Pawlinski, Gourab Bhattacharjee, Jerold Chun, Claudia K Derian, Patricia Andrade-Gordon, Hugh Rosen, Wolfram Ruf

  Source: Nature. 2008 Apr 3

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• The thrombomodulin-protein C system is essential for the maintenance of pregnancy.

  Disruption of the mouse gene encoding the blood coagulation inhibitor thrombomodulin (Thbd) leads to embryonic lethality caused by an unknown defect i…

  Authors: Berend Isermann, Rashmi Sood, Rafal Pawlinski, Mark Zogg, Shawn Kalloway, Jay L Degen, Nigel Mackman, Hartmut Weiler

  Source: Nature medicine. 2003 Mar

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• Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1.

  The serine protease zymogen factor X is converted to its catalytically active form factor Xa by the binary complex of factor VIIa bound to its cell su…

  Authors: Gourab Bhattacharjee, Jasimuddin Ahamed, Rafal Pawlinski, Cheng Liu, Nigel Mackman, Wolfram Ruf, Thomas S Edgington

  Source: Circulation research. 2008 Feb 29

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• A balance between tissue factor and tissue factor pathway inhibitor is required for embryonic development and hemostasis in adult mice.

  Inactivation of the murine tissue factor (TF) gene or tissue factor pathway inhibitor 1 (TFPI) gene results in embryonic lethality, indicating that bo…

  Authors: Brian Pedersen, Todd Holscher, Yuichiro Sato, Rafal Pawlinski, Nigel Mackman

  Source: Blood. 2005 Apr 1

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• HIF-1alpha is essential for myeloid cell-mediated inflammation.

  Granulocytes and monocytes/macrophages of the myeloid lineage are the chief cellular agents of innate immunity. Here, we have examined the inflammator…

  Authors: Thorsten Cramer, Yuji Yamanishi, Björn E Clausen, Irmgard Förster, Rafal Pawlinski, Nigel Mackman, Volker H Haase, Rudolf Jaenisch, Maripat Corr, Victor Nizet,…

  Source: Cell. 2003 Mar 7

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• Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy.

  BACKGROUND: Protease-activated receptor-1 (PAR-1) is the high-affinity receptor for the coagulation protease thrombin. It is expressed by a variety of…

  Authors: Rafal Pawlinski, Michael Tencati, Craig R Hampton, Tetsuro Shishido, Tara A Bullard, Liam M Casey, Patricia Andrade-Gordon, Matthias Kotzsch, Denise Spring, Thomas Luther,…

  Source: Circulation. 2007 Nov 13

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• Use of mouse models to study the role of tissue factor in tumor biology.

  Tissue factor (TF) is the primary initiator of the coagulation cascade and plays an essential role in hemostasis. TF also contributes to many diseases…

  Authors: Rafal Pawlinski, Nigel Mackman

  Source: Seminars in thrombosis and hemostasis. 2008 Mar

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• Tissue factor, coagulation proteases, and protease-activated receptors in endotoxemia and sepsis.

  Inhibition of the tissue factor-factor VIIa complex reduces coagulation and inflammation in animal models of endotoxemia and sepsis and in patients wi…

  Authors: Rafal Pawlinski, Nigel Mackman

  Source: Critical care medicine. 2004 May

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• Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia.

  Sepsis is associated with a systemic activation of coagulation and an excessive inflammatory response. Anticoagulants have been shown to inhibit both …

  Authors: Rafal Pawlinski, Brian Pedersen, Gernot Schabbauer, Michael Tencati, Todd Holscher, William Boisvert, Patricia Andrade-Gordon, Rolf Dario Frank, Nigel Mackman

  Source: Blood. 2004 Feb 15

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• Regulation of tissue factor and inflammatory mediators by Egr-1 in a mouse endotoxemia model.

  In septic shock, tissue factor (TF) activates blood coagulation, and cytokines and chemokines orchestrate an inflammatory response. In this study, the…

  Authors: Rafal Pawlinski, Brian Pedersen, Bettina Kehrle, William C Aird, Rolf D Frank, Mausumee Guha, Nigel Mackman

  Source: Blood. 2003 May 15

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